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NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins
Open accessAbstract
NEDD4–2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4–2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4–2 in regulating membrane proteins, this ligase is essential for maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.
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Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., & Vallon, V. (2006) · Physiological Reviews · doi:10.1152/physrev.00050.2005 · Cited by 689
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Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Correa Marrero, M., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 1,020
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Bensimon, A., Pizzagalli, M. D., Kartnig, F., Dvorak, V., Essletzbichler, P., Winter, G. E., & Superti-Furga, G. (2020) · Cell Chemical Biology · doi:10.1016/j.chembiol.2020.04.003 · Cited by 102
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Hsu, S., Delgado, E. R., Otero, P. A., Teng, K., Kutay, H., Meehan, K. M., Moroney, J. B., Monga, J. K., Hand, N. J., Friedman, J. R., et al. (2016) · Hepatology · doi:10.1002/hep.28573 · Cited by 84
Navarro-Yepes, J., Anandhan, A., Bradley, E., Bohovych, I., Yarabe, B., de Jong, A., Ovaa, H., Zhou, Y., Khalimonchuk, O., Quintanilla-Vega, B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9414-9 · Cited by 37
Metadata
- Authors
- Goel, P., Manning, J. A., & Kumar, S.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 557
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2071962567
- Cited by
- 167
- References
- 2
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Goel, P., Manning, J. A., & Kumar, S. (2015). NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins. Gene. https://doi.org/10.1016/j.gene.2014.11.051
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