Cited by 284Extracellular vesicles in diseaseCellular transport and secretionNanoparticle-Based Drug Delivery

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

Open access
Anand, Sushma, Samuel, Monisha, Kumar, Sharad, Mathivanan, Suresh·2019·Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Abstract

Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate intercellular communication in both physiological and pathological condition. EVs contain selective repertoires of proteins, RNAs, lipids and metabolites that moderate signalling pathways in the recipient cells. The enrichment of a particular set of proteins or RNAs within the EVs highlights the existence of specific sorting mechanisms that orchestrate the selective packaging of the cargo. The molecular machinery of cargo sorting has remained obscure over the years and functional studies are required to understand this complex mechanism. In this article, we offer a brief overview of the molecular mechanisms that are known to regulate sorting of various molecules into EVs. We also discuss how different pathways of biogenesis alter the exosomal cargo as well and the implications of the cellular state on the content of the EVs. Understanding the sorting of exosomal cargo could further be exploited in clinical settings for targeted drug delivery and to block disease progression.

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Crossref · 10.1016/j.bbapap.2019.02.005

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Authors
Anand, S., Samuel, M., Kumar, S., & Mathivanan, S.
Affiliations
  • La Trobe University (AU)
  • South Australia Pathology (AU)
Corresponding author
Mathivanan, Suresh
Venue
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Publisher
Elsevier BV
Published
2019-12
Volume
1867
Issue
12
Pages
140203
ISSN
1570-9639 (ISSN-L)
OpenAlex
W2916217171
Cited by
284
References
132
Citations by year
2026: 21 · 2025: 43 · 2024: 44 · 2023: 44 · 2022: 35 · 2021: 45 · 2020: 36 · 2019: 16
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Figshare (submittedVersion, cc-by-nc-nd)
  • La Trobe University
Funders
  • Australian Research Council (DP170102312, FT180100333)
  • National Health and Medical Research Council (GNT1122437)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
extracellular vesicles, exosomes, cargo sorting, exosomal cargo, vesicle biogenesis, intercellular communication, protein sorting, lipid sorting, targeted drug delivery, cell states
MeSH terms
Extracellular Vesicles, Humans, Proteins, RNA, Protein Transport, Lipid Metabolism

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