Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles
Open accessAbstract
Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate intercellular communication in both physiological and pathological condition. EVs contain selective repertoires of proteins, RNAs, lipids and metabolites that moderate signalling pathways in the recipient cells. The enrichment of a particular set of proteins or RNAs within the EVs highlights the existence of specific sorting mechanisms that orchestrate the selective packaging of the cargo. The molecular machinery of cargo sorting has remained obscure over the years and functional studies are required to understand this complex mechanism. In this article, we offer a brief overview of the molecular mechanisms that are known to regulate sorting of various molecules into EVs. We also discuss how different pathways of biogenesis alter the exosomal cargo as well and the implications of the cellular state on the content of the EVs. Understanding the sorting of exosomal cargo could further be exploited in clinical settings for targeted drug delivery and to block disease progression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exosomes have superior compatibility critical to their function as carriers and a tremendous inherent capacity for receiver cells.
“They have superior compatibility that is critical to their function as carriers [28], which also shows a tremendous inherent capacity for receiver cells [29].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [29]
Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works
Self-citationExtracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692 · see citing works
Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,539 · see citing works
Current knowledge on exosome biogenesis and release
Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362 · see citing works
Exosomes – vesicular carriers for intercellular communication
Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,351 · see citing works
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works
Biogenesis and secretion of exosomes
Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works
Shedding microvesicles: artefacts no more
Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works
The Nature and Significance of Platelet Products in Human Plasma
Wolf, P. (1967) · British Journal of Haematology · doi:10.1111/j.1365-2141.1967.tb08741.x · Cited by 1,725 · see citing works
Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564 · see citing works
Henne, W. M., Buchkovich, N. J., & Emr, S. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.05.015 · Cited by 1,500 · see citing works
Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488 · see citing works
Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works
ExoCarta: A Web-Based Compendium of Exosomal Cargo
Keerthikumar, S., Chisanga, D., Ariyaratne, D., Saffar, H. A., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.019 · Cited by 1,447 · see citing works
Ectosomes and exosomes: shedding the confusion between extracellular vesicles
Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435 · see citing works
Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423 · see citing works
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Raiborg, C., & Stenmark, H. (2009) · Nature · doi:10.1038/nature07961 · Cited by 1,408 · see citing works
Tetraspanins in Extracellular Vesicle Formation and Function
Andreu, Z., & Yáñez-Mó, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00442 · Cited by 1,401 · see citing works
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001450 · Cited by 1,367 · see citing works
Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study
Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015) · BioScience · doi:10.1093/biosci/biv084 · Cited by 1,272 · see citing works
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
Gareau, J. R., & Lima, C. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3011 · Cited by 1,106 · see citing works
Molecular Characterization of Dendritic Cell-Derived Exosomes
Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065 · see citing works
Active Wnt proteins are secreted on exosomes
Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025 · see citing works
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985 · see citing works
Exosomes in tumor microenvironment influence cancer progression and metastasis
Kahlert, C., & Kalluri, R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1020-6 · Cited by 869 · see citing works
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing
Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 865 · see citing works
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Hsu, C., Morohashi, Y., Yoshimura, S., Manrique‐Hoyos, N., Jung, S., Lauterbach, M. A., Bakhti, M., Grønborg, M., Möbius, W., Rhee, J., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911018 · Cited by 860 · see citing works
The Biogenesis and Functions of Exosomes
Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 848 · see citing works
Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles
Pathan, M., Fonseka, P., Chitti, S. V., Kang, T., Sanwlani, R., Deun, J. V., Hendrix, A., & Mathivanan, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1029 · Cited by 769 · see citing works
Baglio, S. R., Rooijers, K., Koppers‐Lalic, D., Verweij, F. J., Pérez-Lanzón, M., Zini, N., Naaijkens, B. A., Perut, F., Niessen, H. W. M., Baldini, N., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0116-z · Cited by 766 · see citing works
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Preprint
Gill, G. (2004) · Genes & Development · doi:10.1101/gad.1214604 · Cited by 752 · see citing works
Haraszti, R. A., Didiot, M., Sapp, E., Leszyk, J., Shaffer, S. A., Rockwell, H. E., Gao, F., Narain, N. R., DiFiglia, M., Kiebish, M. A., et al. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32570 · Cited by 746 · see citing works
Sorting it out: Regulation of exosome loading
Villarroya‐Beltri, C., Baixauli, F., Gutiérrez‐Vázquez, C., Sánchez‐Madrid, F., & Mittelbrunn, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.009 · Cited by 745 · see citing works
Large-scale proteomics and phosphoproteomics of urinary exosomes
Gonzales, P. A., Pisitkun, T., Hoffert, J. D., Tchapyjnikov, D., Star, R. A., Kleta, R., Wang, N. S., & Knepper, M. A. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040406 · Cited by 727 · see citing works
Membrane Microparticles: Two Sides of the Coin
Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698 · see citing works
THE BIOLOGICAL SIGNIFICANCE OF THE THROMBOPLASTIC PROTEIN OF BLOOD
Chargaff, E., & West, R. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34997-9 · Cited by 660 · see citing works
Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
Shurtleff, M. J., Karfilis, K. V., Temoche-Diaz, M. M., Ri, S., & Schekman, R. W. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 648 · see citing works
Membrane scission by the ESCRT-III complex
Wollert, T., Wunder, C., Lippincott‐Schwartz, J., & Hurley, J. H. (2009) · Nature · doi:10.1038/nature07836 · Cited by 634 · see citing works
Mathivanan, S., Lim, J. W. E., Tauro, B. J., Ji, H. L., Moritz, R. L., & Simpson, R. J. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900152-mcp200 · Cited by 593 · see citing works
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 591 · see citing works
Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes
Koppers‐Lalic, D., Hackenberg, M., Bijnsdorp, I. V., van Eijndhoven, M. A. J., Sadek, P., Sie, D., Zini, N., Middeldorp, J. M., Ylstra, B., de Menezes, R. X., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.027 · Cited by 589 · see citing works
Exosomes in bodily fluids are a highly stable resource of disease biomarkers
Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400114 · Cited by 587 · see citing works
Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., & Théry, C. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18397 · Cited by 581 · see citing works
Kim, D., Kang, B., Kim, O. Y., Choi, D., Lee, J., Kim, S. R., Go, G., Yoon, Y. J., Kim, J. H., Jang, S. C., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20384 · Cited by 566 · see citing works
Guduric‐Fuchs, J., O’Connor, A., Camp, B., O’Neill, C. L., Medina, R. J., & Simpson, D. A. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-357 · Cited by 554 · see citing works
Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris
Caruso, S., & Poon, I. K. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01486 · Cited by 541 · see citing works
Cellular Mechanisms Underlying the Formation of Circulating Microparticles
Morel, O., Jesel, L., Freyssinet, J., & Toti, F. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.200956 · Cited by 525 · see citing works
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., & Caplan, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002049 · Cited by 514 · see citing works
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
Villarroya‐Beltri, C., Baixauli, F., Mittelbrunn, M., Fernández‐Delgado, I., Torralba, D., Moreno-Gonzalo, O., Baldanta, S., Enrich, C., Guerra, S., & Sánchez‐Madrid, F. (2016) · Nature Communications · doi:10.1038/ncomms13588 · Cited by 489 · see citing works
Biogenesis and function of ESCRT-dependent extracellular vesicles
Juan, T., & Fürthauer, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.022 · Cited by 464 · see citing works
Schmidt, O., & Teis, D. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.028 · Cited by 456 · see citing works
Buschow, S. I., Hoen, E. N. M. N., van Niel, G., Pols, M. S., ten Broeke, T., Lauwen, M. M., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., Wubbolts, R., et al. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00963.x · Cited by 430 · see citing works
Harding, C. V., Heuser, J., & Stahl, P. D. (1984) · PubMed · Cited by 415 · see citing works
Atkin‐Smith, G. K., Tixeira, R., Paone, S., Mathivanan, S., Collins, C., Liem, M. K., Goodall, K. J., Ravichandran, K. S., Hulett, M. D., & Poon, I. K. H. (2015) · Nature Communications · doi:10.1038/ncomms8439 · Cited by 401 · see citing works
Mechanisms of RNA loading into exosomes
Janas, T., Janas, M. M., Sapoń, K., & Janas, T. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.036 · Cited by 397 · see citing works
EVpedia: a community web portal for extracellular vesicles research
Kim, D.-K., Lee, J., Kim, S. R., Choi, D., Yoon, Y. J., Kim, J. H., Go, G., Nhung, D., Hong, K., Jang, S. C., et al. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu741 · Cited by 393 · see citing works
KRAS-dependent sorting of miRNA to exosomes
Cha, D. J., Franklin, J. L., Dou, Y., Liu, Q., Higginbotham, J. N., Beckler, M. D., Weaver, A. M., Vickers, K. C., Prasad, N., Levy, S., et al. (2015) · eLife · doi:10.7554/elife.07197 · Cited by 360 · see citing works
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling
Verweij, F. J., Bebelman, M. P., Jiménez, C. R., García-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., Haas, R. D. G.-D., Piersma, S. R., Baglio, S. R., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201703206 · Cited by 356 · see citing works
A novel community driven software for functional enrichment analysis of extracellular vesicles data
Pathan, M., Keerthikumar, S., Chisanga, D., Alessandro, R., Ang, C., Askenase, P. W., Batagov, A. O., Benito‐Martín, A., Camussi, G., Clayton, A., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1321455 · Cited by 346 · see citing works
Engineered Exosomes as Vehicles for Biologically Active Proteins
Sterzenbach, U., Putz, U., Low, L., Silke, J., Tan, S., & Howitt, J. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.030 · Cited by 341 · see citing works
The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells
Putz, U., Howitt, J. A., Doan, A., Goh, C., Low, L., Silke, J., & Tan, S. (2012) · Science Signaling · doi:10.1126/scisignal.2003084 · Cited by 312 · see citing works
Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles
Martínez‐Lorenzo, M. J., Anel, A., Gamen, S., Monleón, I., Lasierra, P., Larrad, L., Piñeiro, A., Álava, M. A., & Naval, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1274 · Cited by 306 · see citing works
Cossetti, C., Iraci, N., Mercer, T. R., Leonardi, T., Alpi, E., Drago, D., Alfaro‐Cervelló, C., Saini, H. K., Davis, M. P. A., Schaeffer, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.020 · Cited by 301 · see citing works
Identification of a Conserved Glycan Signature for Microvesicles
Batista, B. S., Eng, W. S., Pilobello, K. T., Hendricks‐Muñoz, K. D., & Mahal, L. K. (2011) · Journal of Proteome Research · doi:10.1021/pr200434y · Cited by 298 · see citing works
Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors
Shen, B., Wu, N., Yang, J.-M., & Gould, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208660 · Cited by 283 · see citing works
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Keerthikumar, S., Gangoda, L., Liem, M. K., Fonseka, P., Atukorala, I., Ozcitti, C., Mechler, Á., Adda, C. G., Ang, C., & Mathivanan, S. (2015) · Oncotarget · doi:10.18632/oncotarget.3801 · Cited by 270 · see citing works
Ectosomes Released by Human Neutrophils Are Specialized Functional Units
Hess, C., Sadallah, S., Hefti, A., Landmann, R. M., & Schifferli, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4564 · Cited by 258 · see citing works
Association of citrullinated proteins with synovial exosomes
Skriner, K., Adolph, K., Jungblut, P. R., & Burmester, G. R. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22276 · Cited by 257 · see citing works
Ubiquitination and the Regulation of Membrane Proteins
Foot, N. J., Henshall, T. L., & Kumar, S. (2016) · Physiological Reviews · doi:10.1152/physrev.00012.2016 · Cited by 257 · see citing works
Cloutier, N., Tan, S., Boudreau, L. H., Cramb, C., Subbaiah, R., Lahey, L., Albert, A., Shnayder, R., Gobezie, R., Nigrovic, P. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201846 · Cited by 254 · see citing works
Witwer, K. W., Soekmadji, C., Hill, A. F., Wauben, M. H. M., Buzás, E. I., Vizio, D. D., Falcón‐Pérez, J. M., Gardiner, C., Hochberg, F. H., Kurochkin, I. V., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1396823 · Cited by 233 · see citing works
Samuel, M., Chisanga, D., Liem, M. K., Keerthikumar, S., Anand, S., Ang, C., Adda, C. G., Versteegen, E., Jois, M., & Mathivanan, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-06288-8 · Cited by 229 · see citing works
Lipid Raft Endocytosis and Exosomal Transport Facilitate Extracellular Trafficking of Annexin A2
Valapala, M., & Vishwanatha, J. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271155 · Cited by 209 · see citing works
Highlights of a new type of intercellular communication: microvesicle-based information transfer
Pap, E., Pállinger, É., Pásztói, M., & Falus, A. (2009) · Inflammation Research · doi:10.1007/s00011-008-8210-7 · Cited by 205 · see citing works
Requirement for Galectin-3 in Apical Protein Sorting
Delacour, D., Cramm‐Behrens, C. I., Drobecq, H., Bivic, A. L., Naim, H. Y., & Jacob, R. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.046 · Cited by 194 · see citing works
Choi, D., Montermini, L., Kim, D., Meehan, B., Roth, F. P., & Rak, J. W. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000644 · Cited by 177 · see citing works
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Falomir‐Lockhart, L. J., Schwalbe, M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1408-1 · Cited by 171 · see citing works
Apical Sorting by Galectin‐3‐Dependent Glycoprotein Clustering
Delacour, D., Greb, C., Koch, A., Salomonsson, E., Leffler, H., Bivic, A. L., & Jacob, R. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00539.x · Cited by 169 · see citing works
NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins
Goel, P., Manning, J. A., & Kumar, S. (2014) · Gene · doi:10.1016/j.gene.2014.11.051 · Cited by 165 · see citing works
NEDD4: The founding member of a family of ubiquitin-protein ligases
Boase, N. A., & Kumar, S. (2014) · Gene · doi:10.1016/j.gene.2014.12.020 · Cited by 157 · see citing works
Weerheim, A. M., Kolb, A. M., Sturk, A., & Nieuwland, R. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5552 · Cited by 155 · see citing works
Blot, V., Perugi, F., Gay, B., Prévost, M., Briant, L., Tangy, F., Abriel, H., Staub, O., Dokhélar, M., & Pique, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01095 · Cited by 154 · see citing works
Putz, U., Howitt, J. A., Lackovic, J., Foot, N. J., Kumar, S., Silke, J., & Tan, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804120200 · Cited by 151 · see citing works
Madrigal‐Matute, J., Lindholt, J. S., Fernandez‐Garcia, C. E., Benito‐Martín, A., Burillo, E., Zalba, G., Beloqui, Ó., Llamas‐Granda, P., Ortíz, A., Egido, J., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000785 · Cited by 148 · see citing works
Stringer, D. K., & Piper, R. C. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008121 · Cited by 144 · see citing works
Shimoda, A., Tahara, Y., Sawada, S., Sasaki, Y., & Akiyoshi, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.126 · Cited by 142 · see citing works
Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential
Gangoda, L., Liem, M. K., Ang, C., Keerthikumar, S., Adda, C. G., Parker, B. S., & Mathivanan, S. (2017) · PROTEOMICS · doi:10.1002/pmic.201600370 · Cited by 138 · see citing works
Kim, B. Y., Olzmann, J. A., Barsh, G. S., Chin, L., & Li, L. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0787 · Cited by 137 · see citing works
Post-translational add-ons mark the path in exosomal protein sorting
Moreno-Gonzalo, O., Fernández‐Delgado, I., & Sánchez‐Madrid, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2690-y · Cited by 128 · see citing works
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation
Zuccato, E., Blott, E. J., Holt, O. J., Sigismund, S., Shaw, M. K., Bossi, G., & Griffiths, G. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03315 · Cited by 123 · see citing works
Chemical and Functional Aspects of Posttranslational Modification of Proteins
Knorre, D. G., Kudryashova, N. V., & Godovikova, T. S. (2009) · Acta Naturae · doi:10.32607/20758251-2009-1-3-29-51 · Cited by 120 · see citing works
Post-Translational Modifications of Exosomal Proteins
Moreno-Gonzalo, O., Villarroya‐Beltri, C., & Sánchez‐Madrid, F. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00383 · Cited by 118 · see citing works
Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease
Vingtdeux, V., Sergeant, N., & Buée, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00229 · Cited by 116 · see citing works
Holme, P. A., Solum, N. O., Brosstad, F. R., Røger, M., & Abdelnoor, M. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648939 · Cited by 115 · see citing works
Tetraspanin protein CD 9 interacts with metalloprotease CD 10 and enhances its release via exosomes
Mazurov, D. V., Barbashova, L., & Filatov, A. V. (2013) · FEBS Journal · doi:10.1111/febs.12110 · Cited by 109 · see citing works
Segura-Morales, C., Begon‐Pescia, C., Chatellard, C., Sadoul, R., Bertrand, É., & Basyuk, E. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413735200 · Cited by 101 · see citing works
Lee, H., Zhang, D., Wu, J., Otterbein, L. E., & Jin, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700165 · Cited by 96 · see citing works
Samuel, M., Bleackley, M. R., Anderson, M. A., & Mathivanan, S. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00766 · Cited by 95 · see citing works
LOSS OF POST-TRANSLATIONAL MODIFICATION SITES IN DISEASE
Li, S., Iakoucheva, L. M., Mooney, S. D., & Predrag Radivojac, A. (2009) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814295291_0036 · Cited by 93 · see citing works
Resolving sorting mechanisms into exosomes
Stoorvogel, W. (2015) · Cell Research · doi:10.1038/cr.2015.39 · Cited by 83 · see citing works
γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells
Surgucheva, I. G., Sharov, V. S., & Surguchov, A. P. (2012) · Biochemistry · doi:10.1021/bi300478w · Cited by 81 · see citing works
Sorting of MHC Class II Molecules into Exosomes through a Ubiquitin‐Independent Pathway
Gauvreau, M., Côté, M., Bourgeois‐Daigneault, M., Rivard, L., Xiu, F., Brunet, A., Shaw, A., Steimle, V., & Thibodeau, J. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00948.x · Cited by 79 · see citing works
Chemical and functional aspects of posttranslational modification of proteins.
Knorre, D. G., Kudryashova, N. V., & Godovikova, T. S. (2009) · PubMed Central · Cited by 77 · see citing works
Ikeda, M., & Longnecker, R. (2006) · Virology · doi:10.1016/j.virol.2006.10.046 · Cited by 72 · see citing works
Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase
McDonald, B., & Martin‐Serrano, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0957 · Cited by 72 · see citing works
Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models
Manning, J. A., & Kumar, S. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.06.004 · Cited by 70 · see citing works
Emerging role of extracellular vesicles in mediating cancer cachexia
Chitti, S. V., Fonseka, P., & Mathivanan, S. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180213 · Cited by 66 · see citing works
Anand, S., Foot, N. J., Ang, C., Gembus, K. M., Keerthikumar, S., Adda, C. G., Mathivanan, S., & Kumar, S. (2018) · PROTEOMICS · doi:10.1002/pmic.201800266 · Cited by 65 · see citing works
Cocucci, E., & Meldolesi, J. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.011 · Cited by 62 · see citing works
Ragusa, M., Barbagallo, C., Cirnigliaro, M., Battaglia, R., Brex, D., Caponnetto, A., Barbagallo, D., Pietro, C. D., & Purrello, M. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00066 · Cited by 56 · see citing works
Ubiquitinated Proteins in Exosomes Secreted by Myeloid-Derived Suppressor Cells
Burke, M. C., Oei, M. S., Edwards, N. J., Ostrand‐Rosenberg, S., & Fenselau, C. (2014) · Journal of Proteome Research · doi:10.1021/pr500854x · Cited by 55 · see citing works
Regulation of the divalent metal ion transporter via membrane budding
Mackenzie, K., Foot, N. J., Anand, S., Dalton, H. E., Chaudhary, N., Collins, B. M., Mathivanan, S., & Kumar, S. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.11 · Cited by 49 · see citing works
Deciphering the role of ectosomes in cancer development and progression: focus on the proteome
Surman, M., Stępień, E. Ł., Hoja-Łukowicz, D., & Przybyło, M. (2017) · Clinical & Experimental Metastasis · doi:10.1007/s10585-017-9844-z · Cited by 49 · see citing works
Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication
Zhang, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3697-3 · Cited by 38 · see citing works
Extending gene ontology in the context of extracellular RNA and vesicle communication
Cheung, K.-H., Keerthikumar, S., Roncaglia, P., Subramanian, S. L., Roth, M. E., Samuel, M., Anand, S., Gangoda, L., Gould, S. J., Alexander, R. P., et al. (2016) · Journal of Biomedical Semantics · doi:10.1186/s13326-016-0061-5 · Cited by 36 · see citing works
Liem, M., Ang, C., & Mathivanan, S. (2017) · Proteomics · doi:10.1002/pmic.201600371 · Cited by 36 · see citing works
Ectosomes and Exosomes-Two Extracellular Vesicles That Differ Only in Some Details
Meldolesi, J. (2016) · Biochemistry & Molecular Biology Journal · doi:10.21767/2471-8084.100012 · Cited by 21 · see citing works
Li, Y., Li, S., Duan, X., Chen, Y., Jiao, B., Ye, H., Yao, M., & Chen, L. (2016) · Mediators of Inflammation · doi:10.1155/2016/7417648 · Cited by 19 · see citing works
The Functional Importance of Tetraspanins in Exosomes
Rana, S., & Zöller, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3697-3_4 · Cited by 11 · see citing works
[Roles of ESCRT complexes in the MVB pathway].
Obita, T., Perišić, O., & Williams, R. L. (2008) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 132 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy, O. M., Nordin, J. Z., Hagey, D. W., de Jong, O. G., Schiffelers, R. M., Andaloussi, S. E., & Vader, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.004 · Cited by 1,217 · see citing works
Exosome Processing and Characterization Approaches for Research and Technology Development
Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623 · see citing works
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01305-4 · Cited by 570 · see citing works
Samuel, M., Fonseka, P., Sanwlani, R., Gangoda, L., Chee, S. H., Keerthikumar, S., Spurling, A., Chitti, S. V., Zanker, D. J., Ang, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24273-8 · Cited by 188 · see citing works
Guo, Q., Furuta, K., Lucien, F., Sanchez, L. H. G., Hirsova, P., Krishnan, A., Kabashima, A., Pavelko, K. D., Madden, B. J., Alhuwaish, H., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.07.019 · Cited by 181 · see citing works
Rastogi, S., Sharma, V., Bharti, P. S., Rani, K., Modi, G. P., Nikolajeff, F. K., & Kumar, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010440 · Cited by 173 · see citing works
Gurunathan, S., Kang, M.-H., Qasim, M., Khan, K., & Kim, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s310357 · Cited by 167 · see citing works
Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling
Zhao, K., Bleackley, M. R., Chisanga, D., Gangoda, L., Fonseka, P., Liem, M. K., Kalra, H., Saffar, H. A., Keerthikumar, S., Ang, C., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0538-8 · Cited by 152 · see citing works
Kwak, G., Cheng, J., Kim, H., Song, S., Lee, S.-J., Yang, Y., Jeong, J., Lee, J. E., Messersmith, P., & Kim, S. H. (2022) · Small · doi:10.1002/smll.202200060 · Cited by 131 · see citing works
Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations
Klyachko, N. L., Arzt, C. J., Li, S. M., Gololobova, O. A., & Batrakova, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121171 · Cited by 132 · see citing works
Che, Y., Shi, X., Shi, Y., Jiang, X., Ai, Q., Shi, Y., Gong, F., & Jiang, W. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.08.010 · Cited by 128 · see citing works
RetractedMechanism of cargo sorting into small extracellular vesicles
Chen, Y., Zhao, Y., Yin, Y., Jia, X., & Mao, L. (2021) · Bioengineered · doi:10.1080/21655979.2021.1977767 · Cited by 126 · see citing works
Extracellular Vesicle Preparation and Analysis: A State‐of‐the‐Art Review
Wang, Z., Zhou, X., Kong, Q., He, H., Sun, J., Qiu, W., Zhang, L. N., & Yang, M. (2024) · Advanced Science · doi:10.1002/advs.202401069 · Cited by 121 · see citing works
Greene, J. A. M., Hernández‐Ortega, K., Quiroz‐Baez, R., Reséndis-Antonio, O., Pichardo‐Casas, I., Sinclair, D. A., Budnik, B., Hidalgo‐Miranda, A., Uribe‐Querol, E., Ramos‐Godínez, M. D. P., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12087 · Cited by 121 · see citing works
MitoEVs: A new player in multiple disease pathology and treatment
Zhou, X., Liu, S., Lu, Y., Wan, M., Cheng, J., & Liu, J. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12320 · Cited by 113 · see citing works
Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer
Simón, L., Campos, A. V., Leyton, L., & Quest, A. F. G. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09890-x · Cited by 110 · see citing works
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
Extracellular vesicles in urological malignancies: an update
Linxweiler, J., & Junker, K. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0261-8 · Cited by 107 · see citing works
Exomeres: A New Member of Extracellular Vesicles Family
Anand, S., Samuel, M., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_5 · Cited by 106 · see citing works
Wang, W., Li, M., Chen, Z., Xu, L., Chang, M., Wang, K., Deng, C., Gu, Y., Zhou, S., Shen, Y., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114954 · Cited by 107 · see citing works
Biogenesis of Extracellular Vesicles
Kang, T., Atukorala, I., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_2 · Cited by 103 · see citing works
Through the back door: Unconventional protein secretion
Cohen, M. J., Chirico, W. J., & Lipke, P. N. (2020) · The Cell Surface · doi:10.1016/j.tcsw.2020.100045 · Cited by 97 · see citing works
Rahmani, A., Saleki, K., Javanmehr, N., Javad, K., Saadat, P., & Nouri, H. R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101106 · Cited by 97 · see citing works
Exosome-mediated stable epigenetic repression of HIV-1
Shrivastava, S., Ray, R. M., Holguin, L., Echavarria, L., Grepo, N., Scott, T. A., Burnett, J., & Morris, K. V. (2021) · Nature Communications · doi:10.1038/s41467-021-25839-2 · Cited by 96 · see citing works
The role of biomechanical stress in extracellular vesicle formation, composition and activity.
Thompson, W., & Papoutsakis, E. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108158 · Cited by 81 · see citing works
Kalra, H., Gangoda, L., Fonseka, P., Chitti, S. V., Liem, M. K., Keerthikumar, S., Samuel, M., Boukouris, S., Saffar, H. A., Collins, C., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1690217 · Cited by 87 · see citing works
Soltanmohammadi, F., Gharehbaba, A. M., Zangi, A. R., Adibkia, K., & Javadzadeh, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117248 · Cited by 84 · see citing works
CRISPR-Cas9 delivery strategies with engineered extracellular vesicles
Lu, Y., Godbout, K., Lamothe, G., & Tremblay, J. P. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102040 · Cited by 87 · see citing works
Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
da Costa, V. R., Araldi, R. P., Vigerelli, H., D’Ámelio, F., Mendes, T. B., Gonzaga, V. F., Policiquio, B. D. O., Colozza‐Gama, G. A., Valverde, C. W., & Kerkis, I. (2021) · Cells · doi:10.3390/cells10102617 · Cited by 79 · see citing works
Kolonics, F., Szeifert, V., Tímár, C. I., Ligeti, E., & Lőrincz, Á. M. (2020) · Cells · doi:10.3390/cells9122718 · Cited by 79 · see citing works
Dendritic Cell-Derived Exosomes in Cancer Immunotherapy
Luo, S., Chen, J., Xu, F., Chen, H., Li, Y., & Li, W. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082070 · Cited by 78 · see citing works
Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and Vaccines
Fernández‐Delgado, I., Calzada‐Fraile, D., & Sánchez‐Madrid, F. (2020) · Cancers · doi:10.3390/cancers12123558 · Cited by 77 · see citing works
Qin, X., He, J., Wang, X., Wang, J., Yang, R., & Chen, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1256687 · Cited by 79 · see citing works
Zhang, Y., Liang, F., Zhang, D., Qi, S., & Liu, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114046 · Cited by 74 · see citing works
The role of extracellular vesicles in animal reproduction and diseases
Gurunathan, S., Kang, M.-H., Song, H., Kim, N. H., & Kim, J. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00715-1 · Cited by 71 · see citing works
Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights
Fakouri, A., Razavi, Z.-S., Mohammed, A. T., Hussein, A. H. A., Afkhami, H., & Hooshiar, M. H. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae021 · Cited by 69 · see citing works
The Role of Extracellular Vesicles in Metabolic Reprogramming of the Tumor Microenvironment
Fridman, E., Ginini, L., & Gil, Z. (2022) · Cells · doi:10.3390/cells11091433 · Cited by 69 · see citing works
Extracellular vesicles in cardiovascular disease
Huang, C., Neupane, Y. R., Lim, X. C., Shekhani, R., Czarny, B., Wacker, M. G., Pastorin, G., & Wang, J. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.08.006 · Cited by 65 · see citing works
Extracellular vesicles: A dive into their role in the tumor microenvironment and cancer progression
Lopez, K., Lai, S., Gonzalez, E. D. J. L., Davila, R., & Shuck, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1154576 · Cited by 67 · see citing works
Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60 · see citing works
Song, T., Eirin, A., Zhu, X., Zhao, Y., Krier, J. D., Tang, H., Jordan, K. L., Woollard, J. R., Taner, T., Lerman, A., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14546 · Cited by 63 · see citing works
Insights Into Exosomal Non-Coding RNAs Sorting Mechanism and Clinical Application
Qiu, Y., Li, P., Zhang, Z., & Wu, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.664904 · Cited by 63 · see citing works
Impact of Chemotherapy on Extracellular Vesicles: Understanding the Chemo-EVs
Razak, N. S. A., Mutalib, N. A., Mohtar, M. A., & Abu, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01113 · Cited by 61 · see citing works
Jahangiri, B., Saei, A. K., Obi, P. O., Asghari, N., Lorzadeh, S., Hekmatirad, S., Rahmati, M., Velayatipour, F., Asghari, M. H., Saleem, A., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166484 · Cited by 60 · see citing works
MSC-derived exosomes injectable hyaluronic acid hydrogel for enhanced chronic wound healing
Yu, H., Zhang, J., Liu, Y., Tian, Y.-F., Milne, C., Jin, P., Li, Q., Song, R., & Wang, W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113985 · Cited by 59 · see citing works
Orench‐Rivera, N., & Kuehn, M. J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.561863 · Cited by 58 · see citing works
Translating extracellular vesicle packaging into therapeutic applications
Ozkocak, D. C., Phan, T. K., & Poon, I. K. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946422 · Cited by 57 · see citing works
Anakor, E., Gall, L. L., Dumonceaux, J., Duddy, W. J., & Duguez, S. (2021) · Cells · doi:10.3390/cells10112930 · Cited by 52 · see citing works
The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis
Liu, M., Wen, Z., Zhang, T., Zhang, L., Liu, X., & Wang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1417758 · Cited by 55 · see citing works
Ou, Y.-H., Liang, J., Czarny, B., Wacker, M. G., Yu, V. C. K., Wang, J., & Pastorin, G. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.006 · Cited by 51 · see citing works
Mathew, B., Mansuri, M. S., Williams, K. R., & Nairn, A. C. (2021) · Brain Sciences · doi:10.3390/brainsci11020258 · Cited by 49 · see citing works
The Evolving Role of Caveolin-1: A Critical Regulator of Extracellular Vesicles
Ni, K., Wang, C., Carnino, J. M., & Jin, Y. (2020) · Medical Sciences · doi:10.3390/medsci8040046 · Cited by 49 · see citing works
Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis
Pavlakis, E., Neumann, M. M., & Stiewe, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249648 · Cited by 45 · see citing works
Extracellular vesicles: The future of therapeutics and drug delivery systems
Uddin, M. J., Mohite, P. B., Munde, S. V., Ade, N., Oladosu, T. A., Chidrawar, V. R., Patel, R. J., Bhattacharya, S., Paliwal, H., & Singh, S. K. (2024) · Intelligent Pharmacy · doi:10.1016/j.ipha.2024.02.004 · Cited by 44 · see citing works
Martin-Rufino, J. D., Espinosa‐Lara, N., Osugui, L., & Sanchez-Guijo, F. M. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00308 · Cited by 42 · see citing works
Samuel, G., Crow, J., Klein, J. B., Merchant, M. L., Nissen, E., Koestler, D. C., Laurence, K., Liang, X., Neville, K. A., Staggs, V. S., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27678 · Cited by 41 · see citing works
Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation
Walsh, S. A., Hoyt, B. W., Rowe, C. J., Dey, D., & Davis, T. A. (2021) · Biomolecules · doi:10.3390/biom11040522 · Cited by 41 · see citing works
Introduction to the Community of Extracellular Vesicles
Fonseka, P., Marzan, A. L., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_1 · Cited by 41 · see citing works
Kotelevets, L., & Chastre, E. (2023) · Cancers · doi:10.3390/cancers15041107 · Cited by 40 · see citing works
Exosomal transmission of viruses, a two-edged biological sword
Mardi, N., Haiaty, S., Rahbarghazi, R., Mobarak, H., Milani, M., Zarebkohan, A., & Nouri, M. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01037-5 · Cited by 39 · see citing works
Xie, L., Chen, J., Ren, X., Zhang, M., Thuaksuban, N., Nuntanaranont, T., & Guan, Z. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104984 · Cited by 40 · see citing works
Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases
Pastor, L., Vera, E., Marín, J. M., & Sánz-Rubio, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020583 · Cited by 39 · see citing works
Therapeutic Potential of Extracellular Vesicles in Hypertension-Associated Kidney Disease
Martínez-Arroyo, O., Ortega, A., Redón, J., & Cortés, R. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.16064 · Cited by 38 · see citing works
EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease
Sherman, C. D., Lodha, S., & Sahoo, S. (2021) · Cells · doi:10.3390/cells10061500 · Cited by 38 · see citing works
Deng, H., & Chen, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.902130 · Cited by 39 · see citing works
Dogrammatzis, C., Saleh, S., Deighan, C., & Kalamvoki, M. (2020) · Journal of Virology · doi:10.1128/jvi.02357-20 · Cited by 37 · see citing works
Hawke, D. C., Watson, A. J., & Betts, D. H. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.11.011 · Cited by 36 · see citing works
Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs)
Awoyemi, T., Cerdeira, A. S., Zhang, W., Jiang, S., Rahbar, M., Logenthiran, P., Redman, C. W. G., & Vatish, M. (2022) · Clinical Science · doi:10.1042/cs20220149 · Cited by 35 · see citing works
Davey, M., Benzina, S., Savoie, M., Breault, G., Ghosh, A., & Ouellette, R. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218330 · Cited by 35 · see citing works
The Role of Extracellular Vesicles in Sperm Function and Male Fertility
Foot, N. J., & Kumar, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_19 · Cited by 35 · see citing works
Extracellular Vesicles as Drug Targets and Delivery Vehicles for Cancer Therapy
Chitti, S. V., Nedeva, C., Manickam, R., Fonseka, P., & Mathivanan, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122822 · Cited by 35 · see citing works
Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer
Carles-Fontana, R., Heaton, N. D., Palma, E., & Khorsandi, S. E. (2022) · Cancers · doi:10.3390/cancers14081865 · Cited by 34 · see citing works
Shi, P., Gao, H., Cheng, Z., Zhao, K., Chen, Y., Chen, X., Gan, W., Zhang, A., Cao, Y., & Zhang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02728-6 · Cited by 36 · see citing works
Potential Therapeutic Applications and Developments of Exosomes in Parkinson’s Disease
Luo, S., Du, L., & Cui, Y. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00195 · Cited by 34 · see citing works
Janas, T., Janas, P., Sapoń, K., & Janas, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228503 · Cited by 34 · see citing works
Fávaro, R. R., Murrieta-Coxca, J. M., Gutiérrez‐Samudio, R. N., Prieto, D. M. M., & Markert, U. R. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13383 · Cited by 34 · see citing works
Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies
Ma, Y., Zhang, X., Liu, C., & Zhao, Y. (2024) · MedComm · doi:10.1002/mco2.70009 · Cited by 35 · see citing works
Lee, N., Canagasingham, A., Bajaj, M., Shanmugasundaram, R., Hutton, A., Bucci, J. A., Graham, P., Thompson, J. E., & Ni, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1019391 · Cited by 33 · see citing works
Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis
García‐Martinez, I., Alén, R., Rada, P., & Valverde, Á. M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00395 · Cited by 32 · see citing works
Loric, S., Denis, J., Desbene, C., Sabbah, M., & Conti, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087208 · Cited by 31 · see citing works
Hernando, S., Santos‐Vizcaíno, E., Igartúa, M., & Hernández, R. M. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1898 · Cited by 32 · see citing works
Mekala, N. K., Trivedi, J., Bhoj, P. S., Togre, N. S., Rom, S., Sriram, U., & Persidsky, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01461-1 · Cited by 29 · see citing works
Extracellular Vesicles as Biomarkers for Parkinson’s Disease: How Far from Clinical Translation?
Gualerzi, A., Picciolini, S., Bedoni, M., Guerini, F. R., Clerici, M., & Agliardi, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021136 · Cited by 30 · see citing works
Delivering therapeutic RNA into the brain using extracellular vesicles
Shirmast, P., Shahri, M. A., Brent, A., Idris, A., & McMillan, N. A. J. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102373 · Cited by 30 · see citing works
The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles
Atukorala, I., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_3 · Cited by 32 · see citing works
Kang, W. Y., Shin, E. K., Kim, E. H., Kang, M., Bang, C. Y., Bang, O. Y., & Cha, J. M. (2024) · Biomaterials Research · doi:10.34133/bmr.0005 · Cited by 30 · see citing works
Mini Review: Current Trends and Understanding of Exosome Therapeutic Potential in Corneal Diseases
Tiwari, A., Singh, A., Verma, S., Stephenson, S., Bhowmick, T., & Sangwan, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684712 · Cited by 29 · see citing works
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging
Rouillard, M. E., Sutter, P. A., Durham, O. R., Willis, C. M., & Crocker, S. J. (2021) · Aging and Disease · doi:10.14336/ad.2021.0608 · Cited by 27 · see citing works
Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
Höhn, J., Tan, W., Carver, A., Barrett, H., & Carver, W. E. (2021) · Cells · doi:10.3390/cells10112933 · Cited by 28 · see citing works
Du, C., Zhao, Y., Wang, K., Nan, X., Chen, R., & Xiong, B. (2022) · Nutrients · doi:10.3390/nu14153057 · Cited by 28 · see citing works
Xiong, L., Wei, Y., Jia, Q., Chen, J., Chen, T., Yuan, J., Pi, C., Liu, H., Tang, J., Yin, S., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01888-1 · Cited by 29 · see citing works
Bauzá‐Martinez, J., Heck, A. J. R., & Wu, W. (2021) · Communications Biology · doi:10.1038/s42003-021-02364-y · Cited by 27 · see citing works
Karagyaur, M. N., Станиславович, Д. С., Basalova, N. A., Aleksandrushkina, N. A., Sagaradze, G. D., Danilova, N. V., Malkov, P. G., Popov, V. S., Никитична, С. М., Efimenko, A. Y., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122031 · Cited by 27 · see citing works
Exosomes: A missing link between chronic systemic inflammation and Alzheimer’s disease?
Ozansoy, M., Mikati, H., Velioğlu, H. A., & Yuluğ, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114161 · Cited by 28 · see citing works
Navigating the brain: the role of exosomal shuttles in precision therapeutics
Fatima, S., Qaiser, A., Andleeb, S., Hashmi, A. H., & Manzoor, S. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1324216 · Cited by 26 · see citing works
The Aquatic Invertebrate Hydra vulgaris Releases Molecular Messages Through Extracellular Vesicles
Moros, M., Fergola, E., Marchesano, V., Mutarelli, M., Tommasini, G., Miedziak, B., Palumbo, G., Ambrosone, A., Tino, A., & Tortiglione, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788117 · Cited by 24 · see citing works
Ali, N. B., Razis, A. F. A., Ooi, D. J., Chan, K. W., Ismail, N., & Foo, J. B. (2022) · Molecules · doi:10.3390/molecules27123941 · Cited by 26 · see citing works
Studying exogenous extracellular vesicle biodistribution by in vivo fluorescence microscopy
Lau, S., Kang, M., Hisey, C. L., & Chamley, L. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050074 · Cited by 25 · see citing works
Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair
Liu, L., Liu, W., Han, Z., Shan, Y., Xie, Y., Wang, J., Qi, H., & Xu, Q. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.10.017 · Cited by 27 · see citing works
Fricke, F., Michalak, M., Warnken, U. H., Haußer, I., Schnölzer, M., Kopitz, J., & Gebert, J. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174162 · Cited by 25 · see citing works
- Authors
- Anand, S., Samuel, M., Kumar, S., & Mathivanan, S.
- Affiliations
- La Trobe University (AU)
- South Australia Pathology (AU)
- Corresponding author
- Mathivanan, Suresh
- Venue
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 1867
- Issue
- 12
- Pages
- 140203
- ISSN
- 1570-9639 (ISSN-L)
- OpenAlex
- W2916217171
- Cited by
- 284
- References
- 132
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 44 · 2023: 44 · 2022: 35 · 2021: 45 · 2020: 36 · 2019: 16
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- La Trobe University
- Funders
- Australian Research Council (DP170102312, FT180100333)
- National Health and Medical Research Council (GNT1122437)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- extracellular vesicles, exosomes, cargo sorting, exosomal cargo, vesicle biogenesis, intercellular communication, protein sorting, lipid sorting, targeted drug delivery, cell states
- MeSH terms
- Extracellular Vesicles, Humans, Proteins, RNA, Protein Transport, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review