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Cited by 30Folate and B Vitamins ResearchMetabolism and Genetic DisordersGenetic Associations and Epidemiology

Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis

Hou, Xiaowen, Chen, Xin, Shi, Jingpu·2015·Gene
DOI 10.1016/j.gene.2015.03.062
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Abstract

The association between 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and premature coronary artery disease (PCAD) is controversial. To explore a more precise estimation of the association, a meta-analysis was conducted in the present study. The relevant studies were identified by searching PubMed, EMBASE, the Web of Science, Cochrane Collaboration Database, Chinese National Knowledge Infrastructure, Wanfang Database and China Biological Medicine up to November, 2014. The meta-analysis was performed by STATA 11. 21 studies with a total of 6912 subjects, including 2972 PCAD patients and 3940 controls. The pooled analysis showed that MTHFR C677T gene polymorphism was probably associated with PCAD (CT vs. CC: OR=1.13, 95% CI=1.01-1.27; dominant model: OR=1.16, 95% CI=1.04-1.29; recessive model: OR=1.19, 95% CI=1.00-1.40; allele analysis: OR=1.17, 95% CI=1.01-1.34). Subgroup analysis by plasma homocysteine concentration showed a significant association in the homocysteine >15μmol/L subgroup (CT vs. CC: OR=1.44, 95% CI=1.10-1.88; TT vs. CC: OR=2.51, 95% CI=1.12-5.63; dominant model: OR=1.51, 95% CI=1.16-1.96; recessive model: OR=2.33, 95% CI=1.05-5.20; allele analysis: OR=1.48, 95% CI=1.18-1.87). Subgroup analysis by continent displayed a significant association among the Asian population (CT vs. CC: OR=1.51, 95% CI=1.23-1.86; TT vs. CC: OR=2.81, 95% CI=1.87-4.23; dominant model: OR=1.65, 95% CI=1.35-2.01; recessive model: OR=2.22, 95% CI=1.53-3.21; allele analysis: OR=1.61, 95% CI=1.37-1.89). The statistical stability and reliability was demonstrated by sensitivity analysis and publication bias outcomes. In conclusion, the meta-analysis suggests that MTHFR C677T gene polymorphism may be associated with PCAD.

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Authors
Hou, X., Chen, X., & Shi, J.
Affiliations
First Hospital of China Medical University (CN)
Corresponding author
Shi, Jingpu
ORCID
Venue
Gene
Publisher
Elsevier BV
Published
2015-07
Volume
565
Issue
1
Pages
39-44
ISSN
0378-1119 (ISSN-L)
DOI
10.1016/j.gene.2015.03.062
OpenAlex
W2045985634
Cited by
30
References
44
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 2
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
MTHFR C677T polymorphism, premature coronary artery disease, genetic susceptibility, methylenetetrahydrofolate reductase, plasma homocysteine, Asian populations, genetic association, coronary risk factors, genetic polymorphism
MeSH terms
Adult, China, Coronary Artery Disease, Homocysteine, Humans, Middle Aged, Publication Bias, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Methylenetetrahydrofolate Reductase (NADPH2), Asian People, Young Adult

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