The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Histone H3 lysine 4 methyltransferase KMT2D
Open accessAbstract
Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5,500 amino acids in size and is partially functionally redundant with KMT2C. KMT2D is widely expressed in adult tissues and is essential for early embryonic development. The C-terminal SET domain is responsible for its H3K4 methyltransferase activity and is necessary for maintaining KMT2D protein stability in cells. KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex. It acts as a scaffold protein within the complex and is responsible for maintaining the stability of UTX. KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of histone H3K27 acetyltransferases CBP and p300 on enhancers, enhancer activation and cell-type specific gene expression during differentiation. KMT2D plays critical roles in regulating development, differentiation, metabolism, and tumor suppression. It is frequently mutated in developmental diseases, such as Kabuki syndrome and congenital heart disease, and various forms of cancer. Further understanding of the mechanism through which KMT2D regulates gene expression will reveal why KMT2D mutations are so harmful and may help generate novel therapeutic approaches.
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Citations
Cites
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Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108566 · Cited by 184
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
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Severe traumatic injury is associated with profound changes in DNA methylation
Eskesen, T. O., Almstrup, K., Elgaard, L., Arleth, T., Lassen, M. L., Creutzburg, A., Jensen, A. H., Breindahl, N., Dinesen, F., Vang, M., et al. (2024) · npj Genomic Medicine · doi:10.1038/s41525-024-00438-4 · Cited by 7
Metadata
- Authors
- Froimchuk, E., Jang, Y., & Ge, K.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 627
- Pages
- 337-342
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2728031786
- Cited by
- 299
- References
- 66
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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