Cited by 1,147Genomics and Chromatin DynamicsEpigenetics and DNA MethylationCancer-related gene regulation

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

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Ruthenburg, Alexander J., Allis, C. David, Wysocka, Joanna·2007·Molecular Cell

Abstract

Cells employ elaborate mechanisms to introduce structural and chemical variation into chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in histone H3 (H3K4). We assess a growing body of literature, including treatment of how the mark is established, the patterns of methylation, and the functional consequences of this epigenetic signature. We discuss structural aspects of the H3K4 methyl recognition by the downstream effectors and propose a distinction between sequence-specific recruitment mechanisms and stabilization on chromatin through methyl-lysine recognition. Finally, we hypothesize how the unique properties of the polyvalent chromatin fiber and associated effectors may amplify small differences in methyl-lysine recognition, simultaneously allowing for a dynamic chromatin architecture.

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Crossref · 10.1016/j.molcel.2006.12.014

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Authors
Ruthenburg, A. J., Allis, C. D., & Wysocka, J.
Affiliations
  • Rockefeller University (US)
  • Stanford Medicine (US)
Corresponding author
Wysocka, Joanna
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2007-01
Volume
25
Issue
1
Pages
15-30
ISSN
1097-2765 (ISSN-L)
OpenAlex
W2024584416
Cited by
1,147
References
104
Citations by year
2026: 23 · 2025: 40 · 2024: 46 · 2023: 39 · 2022: 35 · 2021: 45 · 2020: 51 · 2019: 44 · 2018: 39 · 2017: 54 · 2016: 65 · 2015: 73 · 2014: 68 · 2013: 72 · 2012: 72
FWCI
7.16
Type
journal article
Language
en
Open access
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords
H3K4 methylation, H3K4, chromatin epigenetics, chromatin reader proteins, histone methyltransferase, chromatin fiber structure, chromatin structure
MeSH terms
Amino Acid Sequence, Animals, Histones, Humans, Lysine, Methylation, Molecular Sequence Data, Homeodomain Proteins, Epigenesis, Genetic, Genes, Developmental

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