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Cited by 22

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease

Cakmak Genc, Gunes, Dursun, Ahmet, Karakas Celik, Sevim, Calik, Mustafa, Kokturk, Furuzan, Piskin, Ibrahim Etem·2018·Gene
DOI 10.1016/j.gene.2018.07.062
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Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive neurodegenerative disease which affects children and young adults, caused by a persistent infection of defective measles virus. IFN-λs (IL-28A, IL-28B and IL-29) are a group of cytokines mediating antiviral responses. It has been shown that IL-29 levels are significantly higher in infected cells with defective measles virus. IL-29 expression is thought to be regulated at post-transcriptional level and miRNA-548 family targets the 3'UTR of the IFNL1 gene. Impaired immune system has an important role as well as viral factors in SSPE. The aim of our study investigates whether IL-28B, IL-29 levels and gene polymorphisms contribute to the damaged immune response leading to the development of SSPE. Also possible association of miR-548 family with IL-29 and SSPE is explored. Frequencies of rs12979860, rs8099917, rs30461, serum levels of IL-28B, IL-29 and expression levels of miR-548b, miR-548c, miR-548i are determined at 64 SSPE patients and 68 healthy controls. Serum IL-29 levels are statistically significant higher in SSPE patients. Allele frequencies of rs8099917 are statistically significant higher in SSPE patients and resulted G allele is found to increase 2.183-fold risk of SSPE. The expression levels of miR-548b-5p, miR-548c-5p and miR-548i are found to be statistically significant higher in SSPE patients. Dramatically increased level of IL-29 seen in patient group indicates that the elevated miR-548 expression is co…

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Crossref · 10.1016/j.gene.2018.07.062

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Metadata

Authors
Cakmak Genc, G., Dursun, A., Karakas Celik, S., Calik, M., Kokturk, F., & Piskin, I. E.
ORCID
Cakmak Genc, Gunes
Venue
Gene
Publisher
Elsevier BV
Published
2018-12
Volume
678
Pages
73-78
ISSN
0378-1119
DOI
10.1016/j.gene.2018.07.062
Cited by
22
References
46
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Bulent Ecevit University, Turkey (2014-93106430-01)

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CoChat. (2026). Citation check: IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease. https://app.cochat.ai/papers/10.1016/j.gene.2018.07.062
The paper
Cakmak Genc, G., Dursun, A., Karakas Celik, S., Calik, M., Kokturk, F., & Piskin, I. E. (2018). IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease. Gene. https://doi.org/10.1016/j.gene.2018.07.062

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.