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Cited by 8Dermatology and Skin DiseasesGenetic Associations and EpidemiologyContact Dermatitis and Allergies

Association between polymorphisms and atopic dermatitis susceptibility: a systematic review and meta-analysis

Huang, Yunxia, Zhou, Wei, Liu, Shunan, Zeng, Dan, Zhou, Weikang·2024·Gene
DOI 10.1016/j.gene.2024.148397
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Abstract

Aim Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease that is closely linked to genetic factors. Previous studies have revealed numerous single nucleotide polymorphisms (SNPs) that been related to susceptibility to AD; however, the results are conflicting. Therefore, a meta-analysis was conducted to assess the associations of these polymorphisms and AD risk. Material and methods PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were retrieved to identify eligible studies, with selected polymorphisms being reported in a minimum of three separate studies. The Newcastle-Ottawa Scale (NOS) was used to evaluate study quality. Review Manager 5.3 and STATA 14.0 were used to perform the meta-analysis. Results After screening, 64 studies involving 13 genes (24 SNPs) were selected for inclusion in the meta-analysis. Nine SNPs were positively correlated with AD susceptibility [filaggrin (FLG) R501X, FLG 2282del4, chromosome 11q13.5 rs7927894, interleukin (IL)-17A rs2275913, IL-18 -137 G/C, Toll-like receptor 2 (TLR2) rs5743708, TLR2 A-16934 T, serine protease inhibitor Kazal type-5 (SPINK5) Asn368Ser, interferon-γ (IFN-γ) T874A] and one was negatively associated with AD susceptibility (IL-4 -1098 T/G). The 14 remaining SNPs were not significantly associated with AD susceptibility. Conclusions Nine SNPs that may be risk factors and one SNP that may be a protective factor for AD were identified, providing a referen…

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  • There are dozens of AD susceptibility loci characterized in diverse populations, which mediate functions such as response to interferon gamma (IFNγ), innate immunity, T lymphocyte functions, and epidermal barrier dysfunctions.

    “There are dozens of AD susceptibility loci characterized in diverse populations, which mediate functions such as response to interferon gamma (IFNγ), innate immunity, T lymphocyte functions, and epidermal barrier dysfunctions (Table 1).”

    From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [30]

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Authors
Huang, Y., Zhou, W., Liu, S., Zeng, D., & Zhou, W.
Affiliations
  • Southwest Medical University (CN)
  • Affiliated Hospital of Southwest Medical University (CN)
Corresponding author
  • Zhou, Wei
  • Zhou, Weikang
ORCID
Venue
Gene
Publisher
Elsevier BV
Published
2024-06
Volume
913
Pages
148397
ISSN
0378-1119 (ISSN-L)
DOI
10.1016/j.gene.2024.148397
OpenAlex
W4392946794
Cited by
8
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 2
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Gene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
atopic dermatitis, single nucleotide polymorphisms, genetic susceptibility, filaggrin, IL-17A, IL-18, TLR2, SPINK5, interferon-gamma, IL-4, genetic risk factors
MeSH terms
Dermatitis, Atopic, Humans, Intermediate Filament Proteins, Skin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Toll-Like Receptor 2

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