Skin barrier defects in atopic dermatitis

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,186 · see citing works

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960 · see citing works

Filaggrin Mutations Associated with Skin and Allergic Diseases

Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217 · see citing works

Cytokine modulation of atopic dermatitis filaggrin skin expression

Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084 · see citing works

Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?

Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040 · see citing works

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works

Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome

Chavanas, S., Bodemer, C., Rochat, A., Hamel‐Teillac, D., Ali, M., Irvine, A. D., Bonafé, J., WILKINSON, J. D., Taı̈eb, A., Barrandon, Y., et al. (2000) · Nature Genetics · doi:10.1038/75977 · Cited by 851 · see citing works

γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824 · see citing works

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

Wan, H., Winton, H. L., Soeller, C., Tovey, E. R., Gruenert, D. C., Thompson, P. J., Stewart, G. A., Taylor, G. W., Garrod, D. R., Cannell, M. B., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5844 · Cited by 775 · see citing works

Tight junctions/adherens junctions: basic structure and function

Niessen, C. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700865 · Cited by 756 · see citing works

Tight junction defects in patients with atopic dermatitis

Benedetto, A. D., Rafaels, N. M., McGirt, L. Y., Ivanov, A. I., Georas, S. N., Cheadle, C., Berger, A. E., Zhang, K., Vidyasagar, S., Yoshida, T., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.018 · Cited by 750 · see citing works

Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes

Nomura, I., Goleva, E., Howell, M. D., Hamid, Q., Ong, P. Y., Hall, C. F., Darst, M. A., Gao, B., Boguniewicz, M., Travers, J. B., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3262 · Cited by 731 · see citing works

Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's Health

Shaw, T., Currie, G. P., Koudelka, C. W., & Simpson, E. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.251 · Cited by 721 · see citing works

Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

Steinhoff, M. S., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06176.2003 · Cited by 652 · see citing works

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

Weidinger, S., Illig, T., Baurecht, H., Irvine, A. D., Rodríguez, E., Diaz-Lacava, A. N., Klopp, N., Wagenpfeil, S., Zhao, Y., Liao, H., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.05.004 · Cited by 619 · see citing works

Adult eczema prevalence and associations with asthma and other health and demographic factors: A US population–based study

Silverberg, J. I., & Hanifin, J. M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.031 · Cited by 609 · see citing works

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538 · see citing works

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

Briot, A., Deraison, C., Lacroix, M., Bonnart, C., Robin, A., Besson, C., Dubus, P., & Hovnanian, A. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082242 · Cited by 504 · see citing works

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Kubo, A., Nagao, K., Yokouchi, M., Sasaki, H., & Amagai, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091527 · Cited by 491 · see citing works

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Hankemeier, T., Kezic, S., Wolterbeek, R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p030338 · Cited by 488 · see citing works

Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

Nardo, A. D. (1998) · Acta Dermato Venereologica · doi:10.1080/00015559850135788 · Cited by 483 · see citing works

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L., Saunders, S. P., Mangan, N. E., Callanan, J. J., Kawasaki, H., Shiohama, A., Kubo, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.358 · Cited by 474 · see citing works

Cytokine modulation of atopic dermatitis filaggrin skin expression

Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L. C., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.012 · Cited by 473 · see citing works

Immune mechanisms leading to atopic dermatitis

Novak, N., Bieber, T. R. M., & Leung, D. Y. M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.032 · Cited by 410 · see citing works

Gene polymorphism in Netherton and common atopic disease

Walley, A. J., Chavanas, S., Moffatt, M. F., Esnouf, R. M., Ubhi, B., Lawrence, R., Wong, K., Abecasis, G. R., Jones, E. Y., Harper, J. I., et al. (2001) · Nature Genetics · doi:10.1038/ng728 · Cited by 399 · see citing works

Changes in the Ceramide Profile of Atopic Dermatitis Patients

Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., Kitahara, T., Takema, Y., Koyano, S., Yamazaki, S., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.161 · Cited by 372 · see citing works

The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study

Henderson, J., Northstone, K., Lee, S. P., Liao, H., Zhao, Y., Pembrey, M. E., Mukhopadhyay, S., Smith, G. D., Palmer, C. N. A., McLean, W. H. I., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.026 · Cited by 352 · see citing works

Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood

Barker, J. N. W. N., Palmer, C. N. A., Zhao, Y., Liao, H., Hull, P. R., Lee, S. P., Allen, M. H., Meggitt, S. J., Reynolds, N. J., Trembath, R. C., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700587 · Cited by 346 · see citing works

Cytokine Milieu of Atopic Dermatitis Skin Subverts the Innate Immune Response to Vaccinia Virus

Howell, M. D., Gallo, R. L., Boguniewicz, M., Jones, J. F., Wong, C., Streib, J. E., & Leung, D. Y. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.006 · Cited by 335 · see citing works

Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum

Kežić, S., Kemperman, P. M. J. H., Koster, E. S., de Jongh, C. M., Thio, H. B., Campbell, L., Irvine, A. D., McLean, W. H. I., Puppels, G. J., & Caspers, P. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.29 · Cited by 325 · see citing works

A common variant on chromosome 11q13 is associated with atopic dermatitis

Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.347 · Cited by 317 · see citing works

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

Kawasaki, H., Nagao, K., Kubo, A., Hata, T., Shimizu, A., Mizuno, H., Yamada, T., & Amagai, M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.068 · Cited by 301 · see citing works

Ichthyosis Vulgaris: Identification of a Defect in Synthesis of Filaggrin Correlated with an Absence of Keratohyaline Granules

Sybert, V. P., Dale, B. A., & Holbrook, K. A. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12264813 · Cited by 295 · see citing works

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Kezic, S., O’Regan, G. M., Yau, N., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Irwin McLean, W. H., et al. (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02540.x · Cited by 295 · see citing works

IL-31 regulates differentiation and filaggrin expression in human organotypic skin models

Cornelissen, C., Marquardt, Y., Czaja, K., Wenzel, J., Frank, J., Lüscher‐Firzlaff, J., Lüscher, B., & Baron, J. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.042 · Cited by 292 · see citing works

Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model

Mildner, M., Jin, J., Eckhart, L., Kežić, S., Грубер, Ф., Barresi, C., Stremnitzer, C., Buchberger, M., Mlitz, V., Ballaun, C., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.115 · Cited by 288 · see citing works

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Scharschmidt, T. C., Man, M., Hatano, Y., Crumrine, D. A., Gunathilake, R., Sundberg, J. P., Silva, K. A., Mauro, T. M., Hupe, M., Cho, S., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.06.046 · Cited by 286 · see citing works

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

Kežić, S., O’Regan, G. M., Lutter, R., Jakaša, I., Koster, E. S., Saunders, S. P., Caspers, P. J., Kemperman, P. M. J. H., Puppels, G. J., Sandilands, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.989 · Cited by 276 · see citing works

Cathelicidin deficiency predisposes to eczema herpeticum

HOWELL, M., Wollenberg, A., Gallo, R. L., Flaig, M. J., Streib, J. E., Wong, C., Pavicic, T., Boguniewicz, M., & Leung, D. Y. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1345 · Cited by 274 · see citing works

Basophil recruitment and activation in inflammatory skin diseases

Ito, Y., Satoh, T., Takayama, K., Miyagishi, C., Walls, A. F., & Yokozeki, H. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02570.x · Cited by 272 · see citing works

Deficiency of Dermcidin-Derived Antimicrobial Peptides in Sweat of Patients with Atopic Dermatitis Correlates with an Impaired Innate Defense of Human Skin In Vivo

Rieg, S., Steffen, H., Seeber, S., Humeny, A., Kalbacher, H., Dietz, K., Garbe, C., & Schittek, B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.8003 · Cited by 272 · see citing works

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

Guttman-Yassky, E., Suárez-Fariñas, M., Chiricozzi, A., Nograles, K. E., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Lin, P., Bergman, R., Bowcock, A. M., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.031 · Cited by 268 · see citing works

Cutaneous Defense Mechanisms by Antimicrobial Peptides

Braff, M. H., Bardan, A., Nizet, V., & Gallo, R. L. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23587.x · Cited by 265 · see citing works

Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial Skin Injury

Harder, J., Dressel, S., Wittersheim, M., Cordes, J., Meyer‐Hoffert, U., Mrowietz, U., Fölster‐Holst, R., Proksch, E., Schröder, J., Schwarz, T., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.432 · Cited by 258 · see citing works

Filaggrin Mutations Strongly Predispose to Early-Onset and Extrinsic Atopic Dermatitis

Weidinger, S., Rodríguez, E., Stahl, C., Wagenpfeil, S., Klopp, N., Illig, T., & Novak, N. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700630 · Cited by 254 · see citing works

Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen

Oyoshi, M. K., Murphy, G. F., & Geha, R. S. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.042 · Cited by 245 · see citing works

Prevalent and Rare Mutations in the Gene Encoding Filaggrin Cause Ichthyosis Vulgaris and Predispose Individuals to Atopic Dermatitis

Sandilands, A., O’Regan, G. M., Liao, H., Zhao, Y., Terron-Kwiatkowski, A., Watson, R. M., Cassidy, A., Goudie, D. R., Smith, F. J. D., McLean, W. H. I., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700459 · Cited by 240 · see citing works

IL‐17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

Gutowska‐Owsiak, D., Schaupp, A., Salimi, M., Selvakumar, T. A., McPherson, T., Taylor, S., & Ogg, G. S. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01412.x · Cited by 239 · see citing works

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

Pellerin, L., Henry, J., Hsu, C.-Y., Balica, S., Jean-Decoster, C., Méchin, M.-C., Hansmann, B., Rodriguez, E., Weindinger, S., Schmitt, A.-M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1566 · Cited by 239 · see citing works

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

Gruber, R. W., Elias, P. M., Crumrine, D. A., Lin, T.-K., Brandner, J. M., Hachem, J. P., Presland, R. B., Fleckman, P. H., Janecke, A., Sandilands, A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.053 · Cited by 237 · see citing works

High-Expression of Sphingomyelin Deacylase is an Important Determinant of Ceramide Deficiency Leading to Barrier Disruption in Atopic Dermatitis1

Hara, J., Higuchi, K., Okamoto, R., Kawashima, M., & Imokawa, G. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00072.x · Cited by 229 · see citing works

IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?

Hvid, M., Vestergaard, C., Kemp, K., Christensen, G. B., Deleuran, B. W., & Deleuran, M. S. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.277 · Cited by 219 · see citing works

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin

Hoste, E., Kemperman, P. M. J. H., Devos, M., Denecker, G., Kežić, S., Yau, N. L. H., Gilbert, B., Lippens, S., Groote, P. D., Roelandt, R., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.153 · Cited by 214 · see citing works

The Antimicrobial Protein Psoriasin (S100A7) Is Upregulated in Atopic Dermatitis and after Experimental Skin Barrier Disruption

Gläser, R., Meyer‐Hoffert, U., Harder, J., Cordes, J., Wittersheim, M., Kobliakova, J., Fölster‐Holst, R., Proksch, E., Schröder, J., & Schwarz, T. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.268 · Cited by 214 · see citing works

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

Brown, S., Kroboth, K., Sandilands, A., Campbell, L., Pöhler, E., Kežić, S., Cordell, H. J., McLean, W. H. I., & Irvine, A. D. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.342 · Cited by 211 · see citing works

Mechanism of HBD-3 deficiency in atopic dermatitis

Howell, M. D., Boguniewicz, M., Pastore, S., Novak, N., Bieber, T., Girolomoni, G., & Leung, D. Y. M. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.08.008 · Cited by 208 · see citing works

Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients

Komatsu, N., Saijoh, K., Kuk, C., Liu, C. A., Khan, S., Shirasaki, F., Takehara, K., & Diamandis, E. P. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00562.x · Cited by 204 · see citing works

Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis

Howell, M. D., Novak, N., Bieber, T., Pastore, S., Girolomoni, G., Boguniewicz, M., Streib, J., Wong, C., Gallo, R. L., & Leung, D. Y. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23776.x · Cited by 193 · see citing works

Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema

Nemoto‐Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I., & Shimizu, H. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.280 · Cited by 180 · see citing works

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

Gschwandtner, M., Mildner, M., Mlitz, V., Грубер, Ф., Eckhart, L., Werfel, T., Gutzmer, R., Elias, P. M., & Tschachler, E. (2012) · Allergy · doi:10.1111/all.12051 · Cited by 177 · see citing works

Increased stratum corneum serine protease activity in acute eczematous atopic skin

Voegeli, R., Rawlings, A. V., Breternitz, M., Doppler, S., Schreier, T., & Fluhr, J. W. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09142.x · Cited by 177 · see citing works

Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

Margolis, D. J., Gupta, J., Apter, A. J., Ganguly, T., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., & Mitra, N. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.015 · Cited by 175 · see citing works

Decreased expression of filaggrin in atopic skin

Seguchi, T., Chang-Yi, C., Kusuda, S., Takahashi, M., Aisu, K., & Tezuka, T. (1996) · Archives of Dermatological Research · doi:10.1007/bf02505232 · Cited by 175 · see citing works

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes: IL-22 affects filaggrin expression at multiple levels

Gutowska-Owsiak, D., Schaupp, A. L., Salimi, M., Taylor, S., & Ogg, G. S. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10400.x · Cited by 168 · see citing works

Genetic Association Between an AACC Insertion in the 3′UTR of the Stratum Corneum Chymotryptic Enzyme Gene and Atopic Dermatitis

Vasilopoulos, Y., Cork, M. J., Murphy, R., Williams, H. C., Robinson, D. A., Duff, G. W., Ward, S. J., & Tazi‐Ahnini, R. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22708.x · Cited by 166 · see citing works

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

Rebane, A., Zimmermann, M., Aab, A., Baurecht, H., Koreck, A., Karelson, M., Abram, K., Metsalu, T., Pihlap, M., Meyer, N., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.020 · Cited by 162 · see citing works

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

Chen, H.-W., Common, J., Haines, R. L., Balakrishnan, A., Brown, S., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L., Kroboth, K., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10331.x · Cited by 152 · see citing works

Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes

O’Regan, G. M., Kemperman, P. M. J. H., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Puppels, G. J., McLean, W. H. I., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.038 · Cited by 148 · see citing works

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

Sevilla, L. M., Nachat, R., Groot, K. R., Klement, J. F., Uitto, J., Djian, P., Määttå, A., & Watt, F. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706187 · Cited by 147 · see citing works

Barriers and more: functions of tight junction proteins in the skin

Kirschner, N., & Brandner, J. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06554.x · Cited by 143 · see citing works

Interferon-γ Decreases Ceramides with Long-Chain Fatty Acids: Possible Involvement in Atopic Dermatitis and Psoriasis

Tawada, C., Kanoh, H., Nakamura, M., Mizutani, Y., Fujisawa, T., Banno, Y., & Seishima, M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.364 · Cited by 138 · see citing works

Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure

Schuttelaar, M. L. A., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., de Jongste, J. C., Wijga, A. H., McLean, W. H. I., & Postma, D. S. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02080.x · Cited by 138 · see citing works

Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases

Komatsu, N., Saijoh, K., Toyama, T., Ohka, R., Otsuki, N., Hussack, G., Takehara, K., & Diamandis, E. P. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06754.x · Cited by 136 · see citing works

Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3

Kisich, K. O., Carspecken, C. W., Fiévé, S., Boguniewicz, M., & Leung, D. Y. M. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.022 · Cited by 136 · see citing works

Analysis of SPINK 5, KLK 7 and FLG Genotypes in a French Atopic Dermatitis Cohort

Hubiche, T., Ged, C., Bénard, A., Léauté-Labrèze, C., McElreavey, K., de Verneuil, H., Taı̈eb, A., & Boralévi, F. (2007) · Acta Dermato Venereologica · doi:10.2340/00015555-0329 · Cited by 132 · see citing works

Agonists of Proteinase-Activated Receptor-2 Stimulate Upregulation of Intercellular Cell Adhesion Molecule-1 in Primary Human Keratinocytes via Activation of NF-kappa B

Buddenkotte, J., Stroh, C., Engels, I. H., Moormann, C., Shpacovitch, V. M., Seeliger, S., Vergnolle, N., Vestweber, D., Luger, T. A., Schulze‐Osthoff, K., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23539.x · Cited by 130 · see citing works

Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization

Broccardo, C. J., Mahaffey, S. B., Schwarz, J., Wruck, L. M., David, G. L., Schlievert, P. M., Reisdorph, N. A., & Leung, D. Y. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.033 · Cited by 128 · see citing works

Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3D Skin Construct

Vávrová, K., Henkes, D., Strüver, K., Sochorová, M., Školová, B., Witting, M., Frieß, W., Schreml, S., Meier, R. J., Schäfer‐Korting, M., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.402 · Cited by 125 · see citing works

Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains

Ohnemus, U., Kohrmeyer, K., Houdek, P., Rohde, H., Wladykowski, E., Vidal, S., Horstkotte, M. A., Aepfelbacher, M., Kirschner, N., Behne, M. J., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701070 · Cited by 124 · see citing works

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

Newell, L., Polak, M. E., Perera, J., Owen, C. L., Boyd, P., Pickard, C., Howarth, P. H., Healy, E., Holloway, J. W., Friedmann, P. S., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.148 · Cited by 122 · see citing works

Differential mRNA Expression of Antimicrobial Peptides and Proteins in Atopic Dermatitis as Compared to Psoriasis Vulgaris and Healthy Skin

Gambichler, T., Skrygan, M., Tomi, N. S., Othlinghaus, N., Brockmeyer, N. H., Altmeyer, P. J., & Kreuter, A. (2008) · International Archives of Allergy and Immunology · doi:10.1159/000128582 · Cited by 119 · see citing works

Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic Eczema

Brown, S., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Trembath, R. C., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701206 · Cited by 117 · see citing works

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

Briot, A., Lacroix, M., Robin, A., Steinhoff, M. S., Deraison, C., & Hovnanian, A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.233 · Cited by 111 · see citing works

Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis

Benedetto, A. D., Slifka, M. K., Rafaels, N. M., Kuo, I., Georas, S. N., Boguniewicz, M., Hata, T. R., Schneider, L. C., Hanifin, J. M., Gallo, R. L., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.014 · Cited by 104 · see citing works

Protease Activity Enhances Production of Thymic Stromal Lymphopoietin and Basophil Accumulation in Flaky Tail Mice

Moniaga, C. S., Jeong, S. K., Egawa, G., Nakajima, S., Hara‐Chikuma, M., Jeon, J. E., Lee, S. H., Hibino, T., Miyachi, Y., & Kabashima, K. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.039 · Cited by 102 · see citing works

TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis

Morizane, S., Yamasaki, K., Kajita, A., Ikeda, K., Zhan, M., Aoyama, Y., Gallo, R. L., & Iwatsuki, K. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.006 · Cited by 101 · see citing works

Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis

Sawada, E., Yoshida, N., Sugiura, A., & Imokawa, G. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.07.004 · Cited by 95 · see citing works

SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis

Kusunoki, T., Okafuji, I., Yoshioka, T., Saito, M. K., Nishikomori, R., Heike, T., Sugai, M., Shimizu, A., & Nakahata, T. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.1114 · Cited by 91 · see citing works

Association of Cathepsin E Deficiency with Development of Atopic Dermatitis

Tsukuba, T. (2003) · The Journal of Biochemistry · doi:10.1093/jb/mvg216 · Cited by 90 · see citing works

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

Imokawa, G. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.04.006 · Cited by 89 · see citing works

History of eczema herpeticum is associated with the inability to induce human β-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis

Hata, T., Kotol, P. F., Boguniewicz, M., Taylor, P. A., Paik, A. J., Jackson, M., Nguyen, M., Kabigting, F. D., Miller, J., Gerber, M., et al. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09892.x · Cited by 87 · see citing works

DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss‐of‐function variants

Ziyab, A. H., Karmaus, W., Holloway, J. W., Zhang, H., Ewart, S., & Arshad, S. H. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12000 · Cited by 84 · see citing works

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

Weidinger, S., Baurecht, H., Wagenpfeil, S., Henderson, J., Novak, N., Sandilands, A., Chen, H., Rodríguez, E., O’Regan, G. M., Watson, R., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.050 · Cited by 84 · see citing works

Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines - a possible link between reduced skin barrier function and inflammation?

Hvid, M., Johansen, C., Deleuran, B. W., Kemp, K., Deleuran, M. S., & Vestergaard, C. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01280.x · Cited by 83 · see citing works

Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts

Wiśniewski, J., Agrawal, R., & Woodfolk, J. A. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12016 · Cited by 77 · see citing works

Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis

Wiśniewski, J., Agrawal, R., Minnicozzi, S., Xin, W., Patrie, J. T., Heymann, P. W., Workman, L., Platts‐Mills, T. A. E., Song, T. W., Moloney, M., et al. (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12169 · Cited by 77 · see citing works

IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with Th2 Cytokines to Enhance HSV-1 Replication

Kim, B. E., Bin, L., Ye, Y., Ramamoorthy, P., & Leung, D. Y. M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.223 · Cited by 74 · see citing works

Enhanced expression of the antimicrobial peptide LL-37 in lesional skin of adults with atopic eczema

Ballardini, N., Johansson, C., Lilja, G., Lindh, M., Linde, Y., Scheynius, A., & Agerberth, B. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09095.x · Cited by 73 · see citing works

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

Kim, N., Bae, K. B., Kim, M. O., Yu, D. H., Kim, H. J., Yuh, H. S., Ji, Y. R., Park, S. J., Kim, S., Son, K.-H., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.404 · Cited by 68 · see citing works

Association of β-Defensin 1 Single Nucleotide Polymorphisms with Atopic Dermatitis

de, E. P. M., García‐Vargas, A., Lozano-Inocencio, R., Gallegos‐Arreola, M. P., Sandoval-Ramı́rez, L., Dávalos-Rodríguez, N. O., & Figuera, L. E. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000097023 · Cited by 66 · see citing works

Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations

O’Regan, G. M., Campbell, L., Cordell, H. J., Irvine, A. D., McLean, W. H. I., & Brown, S. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.046 · Cited by 64 · see citing works

Decrease of Ceramides with Very Long–Chain Fatty Acids and Downregulation of Elongases in a Murine Atopic Dermatitis Model

Park, Y.-H., Jang, W.-H., Seo, J. A., Park, M., Lee, T. R., Park, Y.-H., Kim, D. K., & Lim, K. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.333 · Cited by 61 · see citing works

Recombinant Filaggrin Is Internalized and Processed to Correct Filaggrin Deficiency

Stout, T. E., McFarland, T. J., Mitchell, J. C., Appukuttan, B., & Stout, J. T. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.284 · Cited by 56 · see citing works

The barrier function in atopic dry skin. Disturbance of membrane-coating granule exocytosis and formation of epidermal lipids?

Fartasch, M., & Diepgen, T. L. (1992) · PubMed · Cited by 56 · see citing works

Lack of association of SPINK5 polymorphisms with nonsyndromic atopic dermatitis in the population of Northern Germany

Fölster‐Holst, R., Stoll, M., Koch, W. A., Hampe, J., Christophers, E., & Schreiber, S. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06602.x · Cited by 55 · see citing works

Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis

Lesiak, A., Kuna, P., Zakrzewski, M., van Geel, M., Bladergroen, R. S., Przybyłowska, K., Stelmach, I., Majak, P., Hawro, T., Sysa‐Jędrzejowska, A., et al. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01243.x · Cited by 55 · see citing works

Knock‐down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents

van Drongelen, V., Alloul‐Ramdhani, M., Danso, M. O., Mieremet, A., Mulder, A. A., van Smeden, J., Bouwstra, J. A., & Ghalbzouri, A. E. (2013) · Experimental Dermatology · doi:10.1111/exd.12271 · Cited by 52 · see citing works

Microanalysis of an antimicrobial peptide, β-defensin-2, in the stratum corneum from patients with atopic dermatitis

Asano, S., Ichikawa, Y., Kumagai, T., Kawashima, M., & Imokawa, G. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08613.x · Cited by 51 · see citing works

Membrane-coating granules in "dry" non-eczematous skin of patients with atopic dermatitis. A quantitative electron microscopic study

Werner, Y., Lindberg, M., & Forslind, B. (1987) · Acta Dermato Venereologica · doi:10.2340/0001555567385390 · Cited by 48 · see citing works

Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population

Kim, E., Lee, J.-E., Namkung, J., Kim, P.-S., Kim, S., Shin, E., Cho, E.-Y., & Yang, J. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2008.12.005 · Cited by 44 · see citing works

Interleukin‐33 modulates the expression of human β‐defensin 2 in human primary keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis

Alase, A. A., Seltmann, J., Werfel, T., & Wittmann, M. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11140.x · Cited by 41 · see citing works

The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis

Cheng, T., Tjabringa, G. S., van Vlijmen‐Willems, I. M. J. J., Hitomi, K., van Erp, P. E. J., Schalkwijk, J., & Zeeuwen, P. L. J. M. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09156.x · Cited by 39 · see citing works

Localization of Sphingomyelinase in Lesional Skin of Atopic Dermatitis Patients

Kusuda, S., Chang-Yi, C., Takahashi, M., & Tezuka, T. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00370.x · Cited by 39 · see citing works

The relevance of microbial allergens to the IgE antibody repertoire in atopic and nonatopic eczema

Reefer, A. J., Satinover, S. M., Wilson, B. B., & Woodfolk, J. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.042 · Cited by 35 · see citing works

Locus 1q21 Gene Expression Changes in Atopic Dermatitis Skin Lesions: Deregulation of Small Proline-Rich Region 1A

Jarząb, J., Filipowska, B., Żebracka, J., Kowalska, M., Bożek, A., Rachowska, R., Gubała, E., Grzanka, A., Hadas, E., & Jarząb, B. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000232568 · Cited by 33 · see citing works

Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B)

Igawa, S., Kishibe, M., Honma, M., Murakami, M., Mizuno, Y., Suga, Y., Seishima, M., Ohguchi, Y., Akiyama, M., Hirose, K., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.05.004 · Cited by 22 · see citing works

Electron diffraction study of lipids in non-lesional stratum corneum of atopic eczema patients

Janssens, M., Mulder, A. A., van Smeden, J., Pilgram, G. S. K., Wolterbeek, R., Lavrijsen, A. P. M., Koning, R. I., Koster, A. J., & Bouwstra, J. A. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.04.001 · Cited by 18 · see citing works

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

He, H., Suryawanshi, H., Morozov, P. S., Gay-Mimbrera, J., DUCA, E. D., Kim, H. J., Kameyama, N., Estrada, Y. D., Der, E. B., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.042 · Cited by 510 · see citing works

Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march

Czarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.004 · Cited by 261 · see citing works

The skin microbiome of vertebrates

Stegelmeier, A. A., Hoffmann, A. R., & Neufeld, J. D. (2019) · Microbiome · doi:10.1186/s40168-019-0694-6 · Cited by 225 · see citing works

Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection

Esaki, H., Ewald, D. A., Ungar, B., Rozenblit, M., Zheng, X., Xu, H., Estrada, Y. D., Peng, X., Mitsui, H., Litman, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.037 · Cited by 218 · see citing works

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Yosipovitch, G., Misery, L., Proksch, E., Metz, M., Ständer, S., & Schmelz, M. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3296 · Cited by 185 · see citing works

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

Dubin, C., DUCA, E. D., & Guttman-Yassky, E. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1940962 · Cited by 191 · see citing works

The epithelial barrier theory and its associated diseases

Sun, N., Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Bu, X., Li, M., Zhu, X., Babayev, H., Ardıçlı, S., et al. (2024) · Allergy · doi:10.1111/all.16318 · Cited by 188 · see citing works

Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers

He, H., Olesen, C. M., Pavel, A. B., Clausen, M., Wu, J., Estrada, Y. D., Zhang, N., Agner, T., & Guttman‐Yassky, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01768 · Cited by 136 · see citing works

Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

He, H., DUCA, E. D., Diaz, A., Kim, H. J., Gay-Mimbrera, J., Zhang, N., Wu, J., Beaziz, J., Estrada, Y. D., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.041 · Cited by 127 · see citing works

Skin barrier in atopic dermatitis: beyond filaggrin

Zaniboni, M. C., ­Samorano, L. P., Orfali, R. L., & Aoki, V. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164412 · Cited by 121 · see citing works

Overcome the barriers of the skin: exosome therapy

Yang, G. H., Lee, Y. B., Kang, D., Choi, E.-J., Nam, Y., Lee, K. H., You, H., Kang, H. J., An, S., & Jeon, H. (2021) · Biomaterials Research · doi:10.1186/s40824-021-00224-8 · Cited by 123 · see citing works

Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

Banerjee, S., Resch, Y., Chen, K., Swoboda, I., Focke-Tejkl, M., Blatt, K., Novak, N., Wickman, M. C., van Hage, M., Ferrara, R., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.271 · Cited by 107 · see citing works

Emollient treatment of atopic dermatitis: latest evidence and clinical considerations

Hon, K. E., Kung, J. S. C., Ng, W. G. G., & Leung, T. F. (2018) · Drugs in Context · doi:10.7573/dic.212530 · Cited by 109 · see citing works

Current Insights into Immunology and Novel Therapeutics of Atopic Dermatitis

Kader, H. A., Azeem, M., Jwayed, S. A., Al-Shehhi, A., Tabassum, A., Ayoub, M. A., Hetta, ‏. F., Waheed, Y., Iratni, R., Aldhaheri, A., et al. (2021) · Cells · doi:10.3390/cells10061392 · Cited by 95 · see citing works

Tape Stripping Technique for Stratum Corneum Protein Analysis

Clausen, M., Slotved, H., Krogfelt, K. A., & Agner, T. (2016) · Scientific Reports · doi:10.1038/srep19918 · Cited by 87 · see citing works

Staphylococcal Biofilms in Atopic Dermatitis

Gonzalez, T., Myers, J. M. B., Herr, A. B., & Hershey, G. K. K. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0750-x · Cited by 105 · see citing works

Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function

Kim, S. H., Seong, G.-S., & Choung, S. (2020) · Nutrients · doi:10.3390/nu12010249 · Cited by 81 · see citing works

Trends in Atopic Dermatitis—From Standard Pharmacotherapy to Novel Drug Delivery Systems

Souto, E. B., Dias-Ferreira, J., Oliveira, J., Sánchez‐López, E., López-Machado, A., Espina, M., García, M. L., Souto, S. B., Martins‐Gomes, C., & Silva, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225659 · Cited by 76 · see citing works

Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis

Park, D. H., Kim, J. W., Park, H., & Hahm, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084228 · Cited by 76 · see citing works

Contribution of Malassezia spp. to the development of atopic dermatitis

Nowicka, D., & Nawrot, U. (2019) · Mycoses · doi:10.1111/myc.12913 · Cited by 74 · see citing works

The Initiation of Th2 Immunity Towards Food Allergens

Ellenbogen, Y., Jiménez‐Saiz, R., Spill, P., Chu, D. K., Waserman, S., & Jordana, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051447 · Cited by 71 · see citing works

Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

Rinaldi, A. O., Korsfeldt, A., Ward, S., Burla, D., Dreher, A., Gautschi, M., Stolpe, B., Tan, G., Bersuch, E., Melin, D., et al. (2021) · Allergy · doi:10.1111/all.14842 · Cited by 69 · see citing works

JAK-STAT Inhibitors in Atopic Dermatitis from Pathogenesis to Clinical Trials Results

Szalus, K., Trzeciak, M., & Nowicki, R. J. (2020) · Microorganisms · doi:10.3390/microorganisms8111743 · Cited by 68 · see citing works

Oral Janus kinase inhibitors for atopic dermatitis

Mikhaylov, D., Ungar, B., Renert‐Yuval, Y., & Guttman‐Yassky, E. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.01.020 · Cited by 65 · see citing works

Update on the pathogenesis of atopic dermatitis.

Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works

Human organoid biofilm model for assessing antibiofilm activity of novel agents

Wu, B. C., Haney, E. F., Akhoundsadegh, N., Pletzer, D., Trimble, M. J., Adriaans, A. E., Nibbering, P. H., & Hancock, R. E. W. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-00182-4 · Cited by 62 · see citing works

Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis

Liew, W. C., Sundaram, G. M., Quah, S., Lum, G. G., Tan, J. S. L., Ramalingam, R., Common, J., Tang, M. B. Y., Lane, E. B., Thng, S. T. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.007 · Cited by 60 · see citing works

Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort

Gonzalez, T., Stevens, M. L., kyzy, A. B., Alarcón, R., He, H., Kroner, J. W., Spagna, D., Grashel, B., Sidler, E., Martin, L. J., et al. (2020) · Allergy · doi:10.1111/all.14489 · Cited by 58 · see citing works

Epigenetic regulation in the pathogenesis of non-melanoma skin cancer

Kashyap, M. P., Sinha, R., Mukhtar, M. S., & Athar, M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.009 · Cited by 57 · see citing works

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52 · see citing works

Transcriptomic Profiling of Tape-Strips From Moderate to Severe Atopic Dermatitis Patients Treated With Dupilumab

Mikhaylov, D., DUCA, E. D., Olesen, C. M., He, H., Wu, J., Ungar, B., Estrada, Y. D., Zhang, N., Chowdhury, M., Clausen, M., et al. (2021) · Dermatitis · doi:10.1097/der.0000000000000764 · Cited by 49 · see citing works

Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet

Warners, M. J., Vlieg‐Boerstra, B., Verheij, J., van Hamersveld, P. H. P., van Rhijn, B. D., van Ampting, M. T. J., Harthoorn, L. F., de Jonge, W. J., Smout, A. J. P. M., & Bredenoord, A. J. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.107 · Cited by 49 · see citing works

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

van Bilsen, J. H. M., Sienkiewicz‐Szłapka, E., Lozano‐Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., et al. (2017) · Clinical and Translational Allergy · doi:10.1186/s13601-017-0152-0 · Cited by 49 · see citing works

Immunological Aspects of Skin Aging in Atopic Dermatitis

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 50 · see citing works

Yin and Yang: A disrupted skin microbiome and an aberrant host immune response in hidradenitis suppurativa

Schell, S. L., Schneider, A. M., & Nelson, A. M. (2021) · Experimental Dermatology · doi:10.1111/exd.14398 · Cited by 46 · see citing works

In vivo expression of antimicrobial peptides in atopic dermatitis

Clausen, M., Slotved, H., Krogfelt, K. A., Andersen, P. S., & Agner, T. (2015) · Experimental Dermatology · doi:10.1111/exd.12831 · Cited by 44 · see citing works

Atopic dermatitis: pathogenesis and therapeutic intervention

Yue, C., Zhou, H., Wang, X., Yu, J., Hu, Y., Zhou, P., Zhao, F., Zeng, F., Li, G., Li, Y., et al. (2024) · MedComm · doi:10.1002/mco2.70029 · Cited by 50 · see citing works

The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: The establishment of structure–permeation and in silico–in vitro–in vivo relationships

Alalaiwe, A. S., Lin, Y., Lin, C.-H., Wang, P., Lin, J.-Y., & Fang, J. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126955 · Cited by 41 · see citing works

Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy

Montenegro, L., Panico, A. M., Santagati, L. M., Siciliano, E. A., Intagliata, S., & Modica, M. N. (2018) · Nanomaterials · doi:10.3390/nano9010043 · Cited by 40 · see citing works

A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells

Ahn, S., An, S., Lee, M. Y., Lee, E., Pyo, J. J., Kim, J. H., Ki, M. W., Jin, S. H., Ha, J., & Noh, M. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02462-1 · Cited by 40 · see citing works

New and Emerging Therapies for Pediatric Atopic Dermatitis

Nguyen, H. L., Anderson, K., & Tollefson, M. M. (2019) · Pediatric Drugs · doi:10.1007/s40272-019-00342-w · Cited by 39 · see citing works

Assessment of skin barrier function and biochemical changes of ex vivo human skin in response to physical and chemical barrier disruption

Döge, N., Avetisyan, A., Hadam, S., Pfannes, E. K. B., Rancan, F., Blume‐Peytavi, U., & Vogt, A. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.012 · Cited by 39 · see citing works

Pseudomonas Aeruginosa Theft Biofilm Require Host Lipids of Cutaneous Wound

Sinha, M., Ghosh, N., Wijesinghe, D. S., Mathew‐Steiner, S. S., Das, A., Singh, K., Masry, M. S. E., Khanna, S., Inoue, H., Yamazaki, K., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000005252 · Cited by 37 · see citing works

Cyanocobalamin Ultraflexible Lipid Vesicles: Characterization and In Vitro Evaluation of Drug-Skin Depth Profiles

Guillot, A. J., Jornet-Mollá, E., Landsberg, N., Milián-Guimerá, C., Montesinos, M. C., Garrigues, T., & Melero, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030418 · Cited by 37 · see citing works

The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments

Skabytska, Y., Kaesler, S., Volz, T., & Biedermann, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0544-y · Cited by 36 · see citing works

Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model

Lee, S. H., Bae, I., Choi, H., Choi, H. W., Oh, S., Marinho, P. A., Min, D. J., Kim, D.-Y., Lee, T. R., Lee, C. S., et al. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1883-z · Cited by 36 · see citing works

The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms

Smith, A. R., Knaysi, G. A., Wilson, J. M., & Wiśniewski, J. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0674-5 · Cited by 37 · see citing works

Topical therapy of atopic dermatitis with a focus on pimecrolimus

Luger, T. A., Paller, A. S., Irvine, A. D., Sidbury, R., Eichenfield, L. F., Werfel, T., & Bieber, T. R. M. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17272 · Cited by 39 · see citing works

Increasing severity of early‐onset atopic dermatitis, but not late‐onset, associates with development of aeroallergen sensitization and allergic rhinitis in childhood

Schoos, A. M., Chawes, B., Bønnelykke, K., Stokholm, J., Rasmussen, M. A., & Bisgaard, H. F. (2021) · Allergy · doi:10.1111/all.15108 · Cited by 34 · see citing works

Targeting Interleukin 13 for the Treatment of Atopic Dermatitis

Lytvyn, Y., & Gooderham, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020568 · Cited by 37 · see citing works

The Role of Immune Defects and Colonization ofStaphylococcus aureusin the Pathogenesis of Atopic Dermatitis

Nowicka, D., & Grywalska, E. (2018) · Analytical Cellular Pathology · doi:10.1155/2018/1956403 · Cited by 34 · see citing works

Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy

Lohan, S. B., Saeidpour, S., Colombo, M., Staufenbiel, S., Unbehauen, M. L., Wolde-Kidan, A., Netz, R. R., Bodmeier, R. A., Haag, R., Teutloff, C., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050400 · Cited by 32 · see citing works

From the morphological to the transcriptomic characterization of a compromised three-dimensionalin vitromodel mimicking atopic dermatitis

Rouaud, P., Boudier, D., Marchand, L., Barruche, V., Bordes, S., Coppin, H., Roth, M., & Closs, B. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14012 · Cited by 31 · see citing works

2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis

Cheape, A. C., & Murrell, D. F. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1304820 · Cited by 30 · see citing works

Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

Kalailingam, P., Tan, H., Jain, N. K., Sng, M. K., Chan, J. S. K., Tan, N. S., & Thanabalu, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-07125-8 · Cited by 30 · see citing works

Atopic skin: In vivo Raman identification of global molecular signature, a comparative study with healthy skin

Verzeaux, L., Vyumvuhore, R., Boudier, D., Guillou, M. L., Bordes, S., Essendoubi, M., Manfait, M., & Closs, B. (2017) · Experimental Dermatology · doi:10.1111/exd.13388 · Cited by 29 · see citing works

Gardenia jasminoides extract without crocin improved atopic dermatitis-like skin lesions via suppression of Th2-related cytokines in Dfe-induced NC/Nga mice

Park, S. H., An, J. E., Jang, S., Kim, J. Y., Lee, J. W., & Kim, H. K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112015 · Cited by 29 · see citing works

Chemokines and Innate Lymphoid Cells in Skin Inflammation

Sun, Z., Vattepu, R., & Zhang, S. (2021) · Cells · doi:10.3390/cells10113074 · Cited by 29 · see citing works

Scratching damages tight junctions through the Akt–claudin 1 axis in atopic dermatitis

Hu, X., Tang, Y., Ju, Y., Zhang, X. Y., Yan, J.-Y., Wang, C., Yang, Y., Zhu, C., Tang, Z., Zhou, Y., et al. (2020) · Clinical and Experimental Dermatology · doi:10.1111/ced.14380 · Cited by 28 · see citing works

Potential of Tamanu (Calophyllum inophyllum) Oil for Atopic Dermatitis Treatment

Pribowo, A., Girish, J., Gustiananda, M., Nandhira, R. G., & Hartrianti, P. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6332867 · Cited by 32 · see citing works

Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability

Chen, L., Lin, K.-R., Chen, Y., Chiang, Y.-J., Ho, K.-C., Shen, L.-F., Song, I.-W., Liu, K.-M., Yang‐Yen, H., Chen, Y., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.09.017 · Cited by 24 · see citing works

Evaluation of hand hygiene and onset of hand eczema after the outbreak of SARS-CoV-2 in Munich

Kendziora, B., Guertler, A., Ständer, L. M., Frey, S., French, L. E., Wollenberg, A., & Reinholz, M. (2020) · European Journal of Dermatology · doi:10.1684/ejd.2020.3923 · Cited by 25 · see citing works

In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function

Choi, E., Kang, Y., Hwang, S.-H., Kim, J. K., Hong, Y. D., Park, W.-S., Kim, D. H., Kim, E., & Cho, J. Y. (2019) · Molecules · doi:10.3390/molecules24244583 · Cited by 26 · see citing works

The Protective Effect of Adenocaulon himalaicum Edgew. and Its Bioactive Compound Neochlorogenic Acid against UVB-Induced Skin Damage in Human Dermal Fibroblasts and Epidermal Keratinocytes

Ahn, H. S., Kim, H. J., Na, C., Jang, D. S., Shin, Y., & Lee, S. H. (2021) · Plants · doi:10.3390/plants10081669 · Cited by 24 · see citing works

The Efficacy of Moisturisers Containing Ceramide Compared with Other Moisturisers in the Management of Atopic Dermatitis

Nugroho, W. T., Sawitri, S., Astindari, A., Utomo, B., Listiawan, M. Y., Ervianti, E., & Astari, L. (2023) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_991_22 · Cited by 24 · see citing works

Toll‐like receptor 4 attenuates a murine model of atopic dermatitis through inhibition of langerin‐positive DCs migration

Lin, L., Xie, M., Chen, X., Yu, Y., Liu, Y., Lei, K., Wang, D., Zeng, J., Zhou, J., Zhang, L., et al. (2018) · Experimental Dermatology · doi:10.1111/exd.13698 · Cited by 23 · see citing works

Animal Models of Allergic Diseases

Santoro, D., & Marsella, R. (2014) · Veterinary Sciences · doi:10.3390/vetsci1030192 · Cited by 23 · see citing works

Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes

Kim, H.-J., Lee, E., Lee, M. Y., Ahn, S., Kim, J.-M., Liu, J., Jin, S. H., Ha, J., Bae, I., Lee, T. R., et al. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.021 · Cited by 23 · see citing works

Deciphering the Interplay between the Epithelial Barrier, Immune Cells, and Metabolic Mediators in Allergic Disease

Kan, L. L., Li, P., Hon, S. S.-M., Lai, A. Y.-T., Li, A., Wong, K. C., Huang, D., & Wong, C. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136913 · Cited by 22 · see citing works

Deficient functional wound closure as measured by elevated trans-epidermal water loss predicts chronic wound recurrence: An exploratory observational study

Chattopadhyay, D., Sinha, M., Kapoor, A., Kumar, M., Singh, K., Mathew‐Steiner, S. S., & Sen, C. K. (2024) · Scientific Reports · doi:10.1038/s41598-024-74426-0 · Cited by 21 · see citing works

Stabilization and Topical Skin Delivery of Framework Nucleic Acids using Ionic Liquids

Tanner, E. E. L., Wiraja, C., Curreri, C. A., Xu, C., & Mitragotri, S. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000041 · Cited by 21 · see citing works

The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis

Piquero-Casals, J., Carrascosa, J., Morgado-Carrasco, D., Narda, M., Trullàs, C., Granger, C., & Fabbrocini, G. (2021) · Dermatologic Therapy · doi:10.1007/s13555-021-00495-y · Cited by 19 · see citing works

What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model

Fang, Y., Yang, S., Lee, C., Aljuffali, I. A., Kao, H.-C., & Fang, J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.006 · Cited by 21 · see citing works

Regulation and dysregulation of CARD14 signalling and its physiological consequences in inflammatory skin disease

Mellett, M. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104147 · Cited by 22 · see citing works

Host-Microbe Interaction on the Skin and Its Role in the Pathogenesis and Treatment of Atopic Dermatitis

Nowicka, D., Chilicka, K., & Dzieńdziora-Urbińska, I. (2022) · Pathogens · doi:10.3390/pathogens11010071 · Cited by 20 · see citing works

Prebiotics in atopic dermatitis prevention and management

Lee, Y. H., Verma, N. K., & Thanabalu, T. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104352 · Cited by 19 · see citing works

Model learning analysis of 3D optoacoustic mesoscopy images for the classification of atopic dermatitis

Park, S., Saw, S. N., Li, X., Paknezhad, M., Coppola, D., Dinish, U. S., Attia, A. B. E., Yew, Y. W., Thng, S. T. G., Lee, H. K., et al. (2021) · Biomedical Optics Express · doi:10.1364/boe.415105 · Cited by 19 · see citing works

Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis

Jang, H., Lee, J. B., & Yoon, J. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00532-1 · Cited by 19 · see citing works

Do young adults with atopic dermatitis avoid harmful workplace exposure at their first job? A prospective cohort study

Wei, J., Gerlich, J., Vogelberg, C., von Mutius, E., Windstetter, D., Genuneit, J., Weinmayr, G., Nowak, D., & Radon, K. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-015-1078-2 · Cited by 17 · see citing works

The emerging role of skin microbiome in atopic dermatitis and its clinical implication

Stalder, J. ‐., Fluhr, J. W., Foster, T., Glatz, M., & Proksch, E. (2018) · Journal of Dermatological Treatment · doi:10.1080/09546634.2018.1516030 · Cited by 17 · see citing works

Grainyhead‐like transcription factors: guardians of the skin barrier

Deng, Z., Cangkrama, M., Butt, T., Jane, S. M., & Carpinelli, M. R. (2021) · Veterinary Dermatology · doi:10.1111/vde.12956 · Cited by 16 · see citing works

Forsythia velutina Nakai extract: A promising therapeutic option for atopic dermatitis through multiple cell type modulation

Kwon, Y., Kang, Y. J., Kwon, J., Cho, S., Kim, J., Le, T. T., Hwang, H., Deshar, B., Kim, M.-J., Kim, J. Y., et al. (2023) · Allergy · doi:10.1111/all.15967 · Cited by 16 · see citing works

Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis

Özdemіr, E., & Öksüz, L. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04134-w · Cited by 18 · see citing works

1-Iodohexadecane Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice: Possible Involvements of the Skin Barrier and Mast Cell SNARE Proteins

Kim, D. Y., Won, K., Hwang, D. I., Kim, N. Y., Kim, B., & Lee, H. M. (2022) · Molecules · doi:10.3390/molecules27051560 · Cited by 18 · see citing works

LGI 3 promotes human keratinocyte differentiation via the Akt pathway

Kim, I. W., Jeong, H., Kwon, N. S., Baek, K. J., Yun, H., & Kim, D. (2018) · Experimental Dermatology · doi:10.1111/exd.13766 · Cited by 16 · see citing works

In Vitro Anti-Inflammatory and Skin Protective Effects of Codium fragile Extract on Macrophages and Human Keratinocytes in Atopic Dermatitis

Jang, A.-Y., Choi, J., Rod–in, W., Choi, K. Y., Lee, D.-H., & Park, W. J. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2312.12002 · Cited by 15 · see citing works

Effects of Delgocitinib Ointment 0.5% on the Normal Mouse Skin and Epidermal Tight Junction Proteins in Comparison With Topical Corticosteroids

Anagawa-Nakamura, A., Ryoke, K., Yasui, Y., Shoda, T., & Sugai, S. (2020) · Toxicologic Pathology · doi:10.1177/0192623320970896 · Cited by 15 · see citing works

Skin Barrier Dysfunction and the Atopic March

Clausen, M., Agner, T., & Thomsen, S. F. (2015) · Current Treatment Options in Allergy · doi:10.1007/s40521-015-0056-y · Cited by 15 · see citing works

Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways

Elkenani, M., Nyamsuren, G., Raju, P., Liakath‐Ali, K., Hamdaoui, A., Kata, A., Dressel, R., Klonisch, T. C., Watt, F. M., Engel, W., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.04.020 · Cited by 15 · see citing works

KLF feedback loops in innate immunity

Salmon, J. M., Adams, H. R., Magor, G. W., & Perkins, A. C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1606277 · Cited by 13 · see citing works

Biological agents targeting interleukin-13 for atopic dermatitis

Chiricozzi, A., Gori, N., Maurelli, M., Gisondi, P., Caldarola, G., SIMONE, C. D., Peris, K., & Girolomoni, G. (2022) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2035356 · Cited by 14 · see citing works

Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis

Dissanayake, E., Inoue, Y., Ochiai, S., Eguchi, A., Nakano, T., Yamaide, F., Hasegawa, S., Kojima, H., Suzuki, H., Mori, C., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.09.024 · Cited by 14 · see citing works

Antagonism of the interleukin 4 receptor α promotes TH1‐signalling among T cells from patients with atopic dermatitis after stimulation

Brøgger, P., Blom, L. H., Simonsen, S., Thyssen, J. P., & Skov, L. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12835 · Cited by 14 · see citing works

Current and emerging biologics for the treatment of pediatric atopic dermatitis

Ghamrawi, R. I., Bell, K. A., Balogh, E. A., Strowd, L. C., & Feldman, S. R. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1840548 · Cited by 14 · see citing works

Prednisolone-loaded coatable polyvinyl alcohol/alginate hydrogel for the treatment of atopic dermatitis

Lee, H. R., Kim, T. H., Oh, S. H., & Lee, J. H. (2018) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2018.1477317 · Cited by 13 · see citing works

An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study

Afghani, J., Traidl‐Hoffmann, C., Schmitt‐Kopplin, P., Reiger, M., & Mueller, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158791 · Cited by 13 · see citing works

Bortezomib, a proteasome inhibitor, alleviates atopic dermatitis by increasing claudin 1 protein expression

Kim, Y., Cho, N., Cheon, S., & Kim, K. K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.120 · Cited by 13 · see citing works

zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective

Abdulrahman, F. A., Benford, K. A., Lin, G., Maroun, A. J., Sammons, C., Shirzad, D. N., Tsai, H., Brunt, V. L. V., Jones, Z. W., Marquez, J. E., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041673 · Cited by 12 · see citing works

The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models

Plessis, D., Gouws, C., & Nieto, D. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1391259 · Cited by 12 · see citing works

Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC/NgaTndCrlj mice

Singh, C. K., Mintie, C. A., Ndiaye, M. A., Chhabra, G., Roy, S., Sullivan, R., Longley, B. J., Schieke, S. M., & Ahmad, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051472 · Cited by 12 · see citing works

Skin barrier in atopic dermatitis: beyond filaggrin

Zaniboni, M. C., ­Samorano, L. P., Orfali, R. L., & Aoki, V. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164412 · Cited by 121 · see citing works

Chapter 3 Cellular and Molecular Mechanisms in Atopic Dermatitis

Oyoshi, M. K., He, R., Kumar, L., Yoon, J., & Geha, R. S. (2009) · Advances in immunology · doi:10.1016/s0065-2776(09)01203-6 · Cited by 242 · see citing works

Symposium 2-4 (SYP 2-4) : Skin barrier and microbiome in atopic dermatitis

최응호 (2016) · 프로그램북(구 초록집)

Significance of Skin Barrier Dysfunction in Atopic Dermatitis

Kim, B. E., & Leung, D. Y. M. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.3.207 · Cited by 393 · see citing works

Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents

Luger, T. A., Amagai, M., Dréno, B., Dagnelie, M., Liao, W. J., Kabashima, K., Schikowski, T., Proksch, E., Elias, P. M., Simon, M., et al. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.04.007 · Cited by 217 · see citing works