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Cited by 32Growth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormones

Early cessation and non-response are important and possibly related problems in growth hormone therapy: an OZGROW analysis

Hughes, Ian P., Choong, Catherine, Rath, Shoshana, Atkinson, Helen, Cotterill, Andrew, Cutfield, Wayne, Hofman, Paul, Harris, Mark·2016·Growth Hormone & IGF Research
DOI 10.1016/j.ghir.2016.04.006
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Abstract

Objective To investigate growth hormone (GH) treatment and treatment cessation with respect to efficacy and efficiency. To identify factors that best classify or predict cessation type: completed treatment (CT), early cessation (EC), or non-response (NR).Design Observational study (1990-2013) of the Australian GH Program comparing CT, EC, and NR groups with respect to demographic, clinical, and response criteria. All patients treated for GH deficiency (GHD; 909), short stature and slow growth (SSSG; 2144), and Turner Syndrome (TS; 626) were included. Information was retrieved from the OZGROW database.Results 51.9% of patients were EC, 40.7% CT and 7.4% NR.Median treatment durations for NR patients were often longer than patients who completed treatment. EC and NR groups were both associated with poor growth response with males overrepresented.Socioeconomic status differentiated NR (higher) and EC (lower) groups.Conclusions EC was observed at very high rates and appears, generally, to be a little-recognised but frequent problem in GH therapy.EC and delayed recognition of NR may be interrelated being differentiated by the decision to cease or continue treatment following poor response.Poor treatment compliance is likely a major causal factor in EC.Strategies to address poor response and compliance have been developed, however, given the scale of these problems, it may be that long acting GH formulations or individualized treatment need consideration.

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Authors
Hughes, I. P., Choong, C., Rath, S., Atkinson, H., Cotterill, A., Cutfield, W., Hofman, P., & Harris, M.
Affiliations
  • The University of Queensland (AU)
  • The University of Western Australia (AU)
  • Children's Health Queensland Hospital and Health Service (AU)
  • University of Auckland (NZ)
Corresponding author
Hughes, Ian P.
ORCID
Venue
Growth Hormone & IGF Research
Publisher
Elsevier BV
Published
2016-08
Volume
29
Pages
63-70
ISSN
1096-6374 (ISSN-L)
DOI
10.1016/j.ghir.2016.04.006
OpenAlex
W2343383102
Cited by
32
References
40
Citations by year
2026: 7 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2
FWCI
2.34
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Growth Hormone & IGF Research (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion)
  • ResearchSpace (University of Auckland) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
growth hormone therapy, treatment non-response, growth hormone deficiency, Turner syndrome, medication adherence, socioeconomic status, treatment duration
MeSH terms
Adolescent, Australia, Child, Child, Preschool, Female, Growth Disorders, Humans, Hypopituitarism, Male, Social Class, Time Factors, Turner Syndrome, Databases, Factual, Treatment Outcome, Treatment Failure, Human Growth Hormone, Medication Adherence

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