The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
Open accessAbstract
Background Phenotypes of eosinophilic esophagitis (EoE) are not well characterized. Objective To describe clinical features of EoE patients with predefined phenotypes, determine predictors of these phenotypes, and make inferences about the natural history of EoE. Design Retrospective study. Setting Tertiary care center. Patients Incident EoE cases from 2001–2011 who met consensus diagnostic guidelines. Interventions n/a Main outcome measurements Endoscopic phenotypes, including fibrostenotic, inflammatory, or mixed. Other groups of clinical characteristics examined included atopy, level of esophageal eosinophilia, and age of symptom onset. Multinominal logistic regression assessed predictors of phenotype status. Results Of 379 cases of EoE identified, there were no significant phenotypic differences by atopic status or level of eosinophilia. Those with the inflammatory phenotype were more likely to be younger than those with mixed or fibrostenotic (13 vs 29 vs 39 years, respectively; p<0.001), and less likely to have dysphagia, food impaction, and esophageal dilation (p<0.001 for all). The mean symptom length prior to diagnosis was shorter for inflammatory (5 vs 8 vs 8 years; p=0.02). After multivariate analysis, age and dysphagia independently predicted phenotype. The OR for fibrostenosis for each 10-year increase in age was 2.1 (1.7–2.7). The OR for dysphagia was 7.0 (2.6–18.6). Limitations Retrospective, single-center study. Conclusions In this large EoE cohort, the likelihood of fibrostenosing disease increased markedly with age. For every ten year increase in age, the odds of having a fibrostenotic EoE phenotype more than doubled. This association suggests that the natural history of EoE is a progression from an inflammatory to a fibrostenotic disease.
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Cites
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.040 · Cited by 2,073
Self-citationFuruta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Hirano, I., Moy, N., Heckman, M. G., Thomas, C. S., Gonsalves, N., & Achem, S. R. (2013) · Gut · doi:10.1136/gutjnl-2011-301817 · Cited by 945
Eosinophilic Esophagitis: A 10-Year Experience in 381 Children
Liacouras, C. A., Spergel, J. M., Ruchelli, E., Verma, R., Mascarenhas, M., Semeao, E., Flick, J., Kelly, J., Brown–Whitehorn, T., Mamula, P., et al. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00885-2 · Cited by 872
Noel, R. J., Putnam, P. E., & Rothenberg, M. E. (2004) · New England Journal of Medicine · doi:10.1056/nejm200408263510924 · Cited by 721
Straumann, A., Spichtin, H.-P., Grize, L., Bucher, K. A., Beglinger, C., & Simon, H.-U. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.024 · Cited by 710
Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic Esophagitis
Straumann, A., Conus, S., Degen, L., Felder, S., Kummer, M., Engel, H., Bussmann, C., Beglinger, C., Schoepfer, A., & Simon, H. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.048 · Cited by 524
14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis
Spergel, J. M., Brown‐Whitehorn, T. F., Beausoleil, J. L., Franciosi, J., Shuker, M., Verma, R., & Liacouras, C. A. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181788282 · Cited by 467
Esophageal remodeling in pediatric eosinophilic esophagitis
Aceves, S. S., Newbury, R. O., Dohil, R., Bastian, J. F., & Broide, D. H. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.016 · Cited by 432
Straumann, A., Conus, S., Degen, L., Frei, C., Bussmann, C., Beglinger, C., Schoepfer, A., & Simon, H. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.01.017 · Cited by 413
Cited by
Dellon, E. S., Liacouras, C. A., Molina-Infante, J., Furuta, G. T., Spergel, J. M., Zevit, N., Spechler, S. J., Attwood, S. E., Straumann, A., Aceves, S. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.009 · Cited by 1,162
Self-citationPathophysiology of Eosinophilic Esophagitis
O’Shea, K. M., Aceves, S. S., Dellon, E. S., Gupta, S. K., Spergel, J. M., Furuta, G. T., & Rothenberg, M. E. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.06.065 · Cited by 502
Self-citationFood Allergy from Infancy Through Adulthood
Sicherer, S. H., Warren, C. M., Dant, C., Gupta, R. S., & Nadeau, K. C. (2020) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2020.02.010 · Cited by 201
Metadata
- Authors
- Dellon, E. S., Kim, H. P., Sperry, S. L. W., Rybnicek, D. A., Woosley, J. T., & Shaheen, N. J.
- Venue
- Gastrointestinal Endoscopy
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 79
- Issue
- 4
- Pages
- 577-585.e4
- ISSN
- 0016-5107 (ISSN-L)
- OpenAlex
- W2078475980
- Cited by
- 511
- References
- 38
- FWCI
- 24.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Dellon, E. S., Kim, H. P., Sperry, S. L. W., Rybnicek, D. A., Woosley, J. T., & Shaheen, N. J. (2014). A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointestinal Endoscopy. https://doi.org/10.1016/j.gie.2013.10.027
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