The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report — 2021; Focus on recipient characteristics
Open accessAbstract
For over 30 years, the International Society for Heart and Lung Transplantation (ISHLT) International Thoracic Organ Transplant (TTX) Registry has gathered data regarding transplant procedures, donor and recipient characteristics, and outcomes from a global community of transplant centers. Almost 70,000 adult lung transplant procedures have been reported to the Registry since its inception, each one providing an opportunity for a recipient with end-stage lung disease to regain quality of life and longevity. With each year's report, we provide more detailed analyses on a particular focus theme important to recipient outcomes. Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; allograft ischemic time; multiorgan transplantation; and donor and recipient size matching.1-7 In response to a changing regulatory environment, the ISHLT TTX Registry is undergoing an update in data acquisition, and the patient cohort examined in this report is therefore derived from the same data source or datasets as that examined in the 2019 annual reports.2,8-10 We refer the reader to the 2019 and prior reports for a detailed description of the baseline characteristics of the cohort, and additional core analyses not directly related to the focus explored in this year's report. To complement the 2020 report which focussed on donor characteristics, the goal of this year's report was to focus entirely on changes in recipient factors over the past 3 decades and to identify important recipient characteristics and transplant processes that may influence post-transplant outcomes. Due to small numbers, heart-lung transplant recipient characteristics and transplant outcomes have not been included. This 38th annual adult lung transplant report is hence based on data submitted to the ISHLT TTX Registry on 67,493 adult recipients of deceased recipient transplants between January 1, 1992 and June 30, 2018.
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The proportion of IPF recipients increased in the 2010s compared to the 2000s.
“the proportion of IPF recipients increased in the 2010s compared to the 2000s [2]”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [2]
COPD and IPF are important indications for lung transplantation.
“Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are important indications for lung transplantation”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [2]
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Cites
Chambers, D. C., Cherikh, W. S., Harhay, M. O., Hayes, D., Hsich, E., Khush, K. K., Meiser, B., Potena, L., Rossano, J. W., Toll, A. E., et al. (2019) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2019.08.001 · Cited by 1,269 · see citing works
Self-citationNguyen, D. M., & El-Serag, H. B. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2009.12.014 · Cited by 531 · see citing works
Chambers, D. C., Cherikh, W. S., Goldfarb, S. B., Hayes, D., Kucheryavaya, A. Y., Toll, A. E., Khush, K. K., Levvey, B. J., Meiser, B., Rossano, J. W., et al. (2018) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2018.07.020 · Cited by 498 · see citing works
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Research works printed but not linked: 14
- [3]Chambers DC, Yusen RD, Cherikh WS, The registry of the international society for heart and lung transplantation: thirty-fourth adult lung and heart-lung transplantation report-2017; focus theme: allograft ischemic time. J Heart Lung Transplant 2017; 36: 1047– 59. 28784324
- [4]Yusen RD, Christie JD, Edwards LB, The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report−2013; focus theme: age. J Heart Lung Transplant 2013; 32: 965– 78. 24054805
- [5]Yusen RD, Edwards LB, Dipchand AI, The registry of the international society for heart and lung transplantation: thirty-third adult lung and heart-lung transplant report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant 2016; 35: 1170– 84. 27772669
- [6]Yusen RD, Edwards LB, Kucheryavaya AY, The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report−2014; focus theme: retransplantation. J Heart Lung Transplant 2014; 33: 1009– 24. 25242125
- [7]Yusen RD, Edwards LB, Kucheryavaya AY, The registry of the international society for heart and lung transplantation: thirty-second official adult lung and heart-lung transplantation report−2015; focus theme: early graft failure. J Heart Lung Transplant 2015; 34: 1264– 77. 26454740
- [8]Khush KK, Cherikh WS, Chambers DC, The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019; 38: 1056– 66. 31548031 PMC6816343
- [9]Rossano JW, Singh TP, Cherikh WS, The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric heart transplantation report −2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019; 38: 1028– 41. 31548029 PMC6819143
- [10]Hayes D Jr, Cherikh WS, Chambers DC, The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019; 38: 1015– 27. 31548028 PMC6816344
- [11]Hayes D Jr., Harhay MO, Cherikh WS, The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-fourth pediatric lung transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transplant 2021. PMC10281818 34561022
- [12]Khush KK, Hsich E, Potena L, The international thoracic organ transplant registry of the international society for heart and lung transplantation: 38th adult heart transplantation report-2021; focus on recipient characteristics. J Heart Lung Transplant 2021. PMC10285650 34446355
- [13]Singh TP, Cherikh WS, Hsich E, The international thoracic organ transplant registry of the international society for heart and lung transplantation: 24th pediatric heart transplantation report-2021; focus theme: changing recipient characteristics. J Heart Lung Transplant 2021. PMC10281818 34561022
- [14]Chambers DC, Zuckermann A, Cherikh WS, The international thoracic organ transplant registry of the international society for heart and lung transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics. J Heart Lung Transplant 2020; 39: 1016– 27. 32782073 PMC7737221
- [15]Kulkarni HS, Cherikh WS, Chambers DC, Bronchiolitis obliterans syndrome-free survival after lung transplantation: an international society for heart and lung transplantation thoracic transplant registry analysis. J Heart Lung Transplant 2019; 38: 5– 16. 30391193 PMC6431291
- [16]Paraskeva MA, Edwards LB, Levvey B, Outcomes of adolescent recipients after lung transplantation: an analysis of the international society for heart and lung transplantation registry. J Heart Lung Transplant 2018; 37: 323– 31. 28320631
Cited by
Sorted by citations
Singh, T. P., Hsich, E., Cherikh, W. S., Perch, M., Hayes, D., Lewis, A., Dellgren, G., & Cogswell, R. (2025) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2025.04.014 · Cited by 135 · see citing works
Self-citationHalpern, S. E., Wright, M. C., Madsen, G., Chow, B., Harris, C. S., Haney, J. C., Klapper, J. A., Bottiger, B. A., & Hartwig, M. G. (2022) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2022.07.015 · Cited by 22 · see citing works
Indications for Lung Transplantation and Patient Selection
Son, J., & Shin, C. (2022) · Journal of Chest Surgery · doi:10.5090/jcs.22.057 · Cited by 9 · see citing works
“Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are important indications for lung transplantation, and the proportion of IPF recipients increased in the 2010s compared to the 2000s [2].”
BackgroundTwenty-year survival following lung transplantation
Miggins, J. J., Reul Jr, R. M., Barrett, S., Rana, A., Alnajar, A., Dunson, J., Shafii, A., Garcha, P., Goss, J., & Loor, G. (2023) · Journal of Thoracic Disease · doi:10.21037/jtd-22-1414 · Cited by 8 · see citing works
“Importantly, advanced donor age was not associated with reduced likelihood of 10+ or 20+ year survival after controlling for other factors ( Tables 2,3 ).”
- Authors
- Chambers, D. C., Perch, M., Zuckermann, A., Cherikh, W. S., Harhay, M. O., Hayes, D., Hsich, E., Khush, K. K., Potena, L., Sadavarte, A., Lindblad, K., Singh, T. P., & Stehlik, J.
- Affiliations
- International Society for Heart and Lung Transplantation (US)
- Corresponding author
- Stehlik, Josef
- ORCID
- Venue
- The Journal of Heart and Lung Transplantation
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 40
- Issue
- 10
- Pages
- 1060-1072
- ISSN
- 1053-2498 (ISSN-L)
- PMC
- PMC10285650
- OpenAlex
- W3192234234
- Cited by
- 596
- References
- 3
- Citations by year
- 2026: 75 · 2025: 100 · 2024: 144 · 2023: 186 · 2022: 81 · 2021: 10
- FWCI
- 98.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Heart and Lung Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- International Society for Heart and Lung Transplants
- CareDx
- Roche
- Astellas Pharma
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- recipient characteristics, end-stage lung disease, deceased donor transplantation, transplant outcomes, recipient age, retransplantation, early graft failure, multiorgan transplantation, donor-recipient size matching
- MeSH terms
- Adult, Aged, Female, Heart Diseases, Humans, Lung Diseases, Male, Middle Aged, Registries, Societies, Medical, Thoracic Surgery, Global Health, Survival Rate, Heart-Lung Transplantation, Young Adult, Transplant Recipients
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