Dietary immature Citrus unshiu alleviates UVB- induced photoaging by suppressing degradation of basement membrane in hairless mice
Open accessAbstract
Ultraviolet (UV) irradiation induces physiological and morphological skin damage, resulting in skin dryness, wrinkle formation, and loss of elasticity. The basement membrane (BM) has been shown to play crucial roles in binding epidermis to dermis tightly, regulating cell differentiation and proliferation, and signaling protein production. Dietary flavonoids have been revealed to improve the damage caused by UV exposure. Immature Citrus unshiu is known to contain high concentrations of flavonoids such as hesperidin and narirutin. In this study, the effects of immature Citrus unshiu powder (ICP) on photoaged skin were demonstrated using UVB irradiated hairless mice. Oral administration of ICP improved loss of skin hydration and increase of transepidermal water loss. The histological analyses of hairless mice dorsal skin revealed that oral administration of ICP improved UVB-induced overgrowth of epidermal cell, suppressed epidermal cell mortality and BM destruction. Therefore, the administration of ICP could improve photoaging by protecting the tissues around BM.
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Oral administration of immature Citrus unshiu powder improves UVB-induced loss of skin hydration, increase in transepidermal water loss, and overgrowth of epidermal cells, while suppressing epidermal cell mortality and basement membrane destruction, in hairless mice.
“Oral administration of immature Citrus unshiu powder improves UVB-induced loss of skin hydration, the increase in transepidermal water loss, and the overgrowth of epidermal cells, while suppressing epidermal cell mortality and basement membrane destruction, in hairless mice [104].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [104]
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References 30 · Cited by 21
- Authors
- Tamaru, E., Watanabe, M., & Nomura, Y.
- Affiliations
- Tokyo University of Agriculture and Technology (JP)
- Corresponding author
- Nomura, Yoshihiro
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 6
- Issue
- 6
- Pages
- e04218
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC7303560
- OpenAlex
- W3034826035
- Cited by
- 21
- References
- 30
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tokyo University of Agriculture and Technology
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Keywords
- photoaging, UVB irradiation, basement membrane, flavonoids, hesperidin, narirutin, skin hydration, transepidermal water loss, epidermal proliferation, hairless mice, dietary supplementation
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