The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins
Open accessAbstract
Mycotoxins present a great concern to food safety and security due to their adverse health and socio-economic impacts. The necessity to formulate novel strategies that can mitigate the economic and health effects associated with mycotoxin contamination of food and feed commodities without any impact on public health, quality and nutritional value of food and feed, economy and trade industry become imperative. Various strategies have been adopted to mitigate mycotoxin contamination but often fall short of the required efficacy. One of the promising approaches is the use of bioactive plant components/metabolites synergistically with mycotoxin-absorbing components in order to limit exposure to these toxins and associated negative health effects. In particular, is the fabrication of β-cyclodextrin-based nanosponges encapsulated with bioactive compounds of plant origin to inhibit toxigenic fungi and decontaminate mycotoxins in food and feed without leaving any health and environmental hazard to the consumers. The present paper reviews the use of botanicals extracts and their phytochemicals coupled with β-cyclodextrin-based nanosponge technology to inhibit toxigenic fungal invasion and detoxify mycotoxins.
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Excessive use and improper handling of synthetic fungicides can have detrimental impacts on people, the environment, and non-target organisms, negatively influencing biodiversity.
“excessive use and improper handling of synthetic fungicides can have detrimental impacts on people, the environment, and non-target organisms, which has a negative influence on biodiversity.”
From Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions (2023) · cites this paper as [6]
The Introduction (page unavailable) says that long-term extreme use of chemicals for mycotoxin decontamination is limited by residual toxic products and public-health and environmental concerns. That supports the general concern about excessive chemical use, but the passage does not specifically address improper handling of synthetic fungicides, harm to non-target organisms, or biodiversity loss. (LLM, conf=0.84)
Experimental — accuracy not yet measuredContinuous use of synthetic fungicides leads to resistance.
“Continuous use leads to resistance”
From Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions (2023) · cites this paper as [6]
The ‘Current limitations on the use of phytochemicals as biofungicide’ section discusses fungal resistance where conventional antifungal drugs are ineffective. The Introduction discusses limits on long-term use of chemical treatments, but identifies toxicity and environmental concerns—not resistance. Neither passage says continuous use of synthetic fungicides leads to resistance; page numbers are unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredSynthetic fungicides have been used to manage plant diseases caused by phytopathogenic fungi, but their use has been criticized due to unfavorable side effects.
“Synthetic fungicides have been employed to manage plant diseases caused by phytopathogenic fungi but their use has been criticized due to unfavorable side effects.”
From Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions (2023) · cites this paper as [6]
The Introduction says chemical methods have been used to prevent toxigenic fungal growth and that their use is limited by residual toxicity, public-health and environmental concerns. The section on current limitations of phytochemicals also presents botanical agents as alternatives to conventional fungicides. Neither passage specifically establishes that synthetic fungicides were used to manage plant diseases caused by phytopathogenic fungi. (LLM, conf=0.82)
Experimental — accuracy not yet measuredConstituent molecules of synthetic fungicides have been linked to chronic human illnesses and ozone layer depletion.
“constituent molecules of synthetic fungicides have been linked to chronic human illnesses in either intake or exposure scenarios in addition to ozone layer depletion”
From Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions (2023) · cites this paper as [6]
The Introduction describes human health effects and ingestion or exposure routes for mycotoxins, not for synthetic fungicides. The section on current limitations of phytochemicals calls natural antifungal formulations safer and more eco-friendly than standard agents, but does not link fungicide constituents to chronic illness or ozone-layer depletion. Searches for synthetic fungicide harms and ozone depletion found no passage addressing those links. (LLM, conf=0.76)
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Vila-Donat, P., Marín, S., Sanchis, V., & Ramos, A. J. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.02.044 · Cited by 305 · see citing works
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Sorted by citations
Deresa, E. M., & Diriba, T. F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13810 · Cited by 142 · see citing works
- Authors
- Makhuvele, R., Naidu, K., Gbashi, S., Thipe, V. C., Adebo, O. A., & Njobeh, P. B.
- Affiliations
- University of Johannesburg (ZA)
- Corresponding author
- Makhuvele, Rhulani
- Njobeh, Patrick B.
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 6
- Issue
- 10
- Pages
- e05291
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC7586119
- OpenAlex
- W3094301676
- Cited by
- 176
- References
- 1
- Citations by year
- 2026: 18 · 2025: 40 · 2024: 40 · 2023: 35 · 2022: 28 · 2021: 12 · 2020: 2 · 2014: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Johannesburg
- Department of Science and Innovation, South Africa
- National Research Foundation
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- mycotoxins, toxigenic fungi, plant extracts, phytochemicals, β-cyclodextrin nanosponges, mycotoxin detoxification, antifungal activity, food and feed contamination, botanicals, bioactive compound encapsulation
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