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Cited by 81Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers

The DOI matches its Crossref record; 227 of the 234 references it cites were found in a registry or an index.

RETRACTED: Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy

Open access
Zhang, Wenjie, Taheri-Ledari, Reza, Ganjali, Fatemeh, Afruzi, Fereshte Hassanzadeh, Hajizadeh, Zoleikha, Saeidirad, Mahdi, Qazi, Fateme Sadat, Kashtiaray, Amir, Sehat, Samin Sadat, Hamblin, Michael R., Maleki, Ali·2022·Heliyon
DOI 10.1016/j.heliyon.2022.e09577PMC PMC9189039
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Abstract

Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.

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Crossref · 10.1016/j.heliyon.2022.e09577This paper is marked retracted.

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Graphical abstract
Graphical abstract CC BY-NC-ND · PubMed Central
Figure 1 a) H2O2-triggered release procedure of HNTs@PVA@PA. Figure a was adapted by permission from: Chemical Engineering Journal, 2020, 380, 122474 [94]. b) The illustration of the ultrasound-responsive drug release using a vibration enhancer. (i) Hydrogel microbeads contained vibration enhancers and drug models. (ii) Vibration enhancers in the hydrogel microbeads under the applied ultrasound irradiation. (iii) Drug models were released from hydrogel microbeads by the vibration of hydrogel microbeads and vibration enhancers. Figure c was adapted by permission from: Materials & Design, 2021, 203, 109580 [99].
Figure 1 a) H2O2-triggered release procedure of HNTs@PVA@PA. Figure a was adapted by permission from: Chemical Engineering Journal, 2020, 380, 122474 [94]. b) The illustration of the ultrasound-responsive drug release using a vibration enhancer. (i) Hydrogel microbeads contained vibration enhancers and drug models. (ii) Vibration enhancers in the hydrogel microbeads under the applied ultrasound irradiation. (iii) Drug models were released from hydrogel microbeads by the vibration of hydrogel microbeads and vibration enhancers. Figure c was adapted by permission from: Materials & Design, 2021, 203, 109580 [99].CC BY-NC-ND · PubMed Central
Figure 2 The sketch of the shape and morphology of some of the drug nanocarriers and the conjugated biological sections, utilized by the researchers in the last decade. Photothermal therapy (PTT) defines as a cancer treatment approach using electromagnetic irradiation. The conjugation of nanomaterials with biological sections (aptamers, antibodies, CPP, FA) creates various nanocarriers for drug loading and transferring the cargo to the target cells.
Figure 2 The sketch of the shape and morphology of some of the drug nanocarriers and the conjugated biological sections, utilized by the researchers in the last decade. Photothermal therapy (PTT) defines as a cancer treatment approach using electromagnetic irradiation. The conjugation of nanomaterials with biological sections (aptamers, antibodies, CPP, FA) creates various nanocarriers for drug loading and transferring the cargo to the target cells.CC BY-NC-ND · PubMed Central
Figure 3 The chemical structures of a) carrageenan. Figure a was adapted by permission from: Marine Drugs, 2020, 18, 658 [137], b) dextran, c) chitosan, d) hyaluronic acid. Figures b–d was adapted by permission from: International Journal of Molecular Sciences, 2020, 21, 9159 [138].
Figure 3 The chemical structures of a) carrageenan. Figure a was adapted by permission from: Marine Drugs, 2020, 18, 658 [137], b) dextran, c) chitosan, d) hyaluronic acid. Figures b–d was adapted by permission from: International Journal of Molecular Sciences, 2020, 21, 9159 [138].CC BY-NC-ND · PubMed Central
Figure 4 a) The schematic illustration of the receptor-mediated endocytosis (RME) for drug conjugate, drug release process, and drug attachment to the target protein. Figure a was adapted by permission from: Bioconjugate chemistry, 2010, 21, 979–987 [148]. b) The schematic illustration of the suggested hypothesis of utilizing AS1411 derivatives for carrying C8 ligand into nucleolin-overexpressed cancer cells. Figure b was adapted by permission from: Scientific reports, 2019, 9, 1–12 [154]. c) The schematic illustration of the internalization of GEM-conjugated polyamino acid-based micelles and their reduction-responsive drug release. Figure c was adapted by permission from: Polymer Chemistry, 2017, 8, 2490–2498 [157]. d) The schematic illustration of the structure and suggested mechanism for the targeted impact of CSKSSDYQC-dextran-poly (lactic-co-glycolic acid) nanoparticles (CSK-DEX-PLGA-NPs = CDPs). Figure d was adapted by permission from: Molecular Pharmaceutics, 2019, 16, 518–532 [158].
Figure 4 a) The schematic illustration of the receptor-mediated endocytosis (RME) for drug conjugate, drug release process, and drug attachment to the target protein. Figure a was adapted by permission from: Bioconjugate chemistry, 2010, 21, 979–987 [148]. b) The schematic illustration of the suggested hypothesis of utilizing AS1411 derivatives for carrying C8 ligand into nucleolin-overexpressed cancer cells. Figure b was adapted by permission from: Scientific reports, 2019, 9, 1–12 [154]. c) The schematic illustration of the internalization of GEM-conjugated polyamino acid-based micelles and their reduction-responsive drug release. Figure c was adapted by permission from: Polymer Chemistry, 2017, 8, 2490–2498 [157]. d) The schematic illustration of the structure and suggested mechanism for the targeted impact of CSKSSDYQC-dextran-poly (lactic-co-glycolic acid) nanoparticles (CSK-DEX-PLGA-NPs = CDPs). Figure d was adapted by permission from: Molecular Pharmaceutics, 2019, 16, 518–532 [158].CC BY-NC-ND · PubMed Central
Figure 5 a) Preparation route of Pab-functionalized MWCNTs. (DSPE-PEG: Distearoyl-sn-glycero-3- phosphoethanolamine conjugated to polyethylene glycol5000 terminated with a methoxy group, Mal: maleimide, FITC: fluorescein isothiocyanate). This figure was adapted by permission from: ACS applied materials & interfaces, 2018, 10, 33464–33473 [172]. b) A schematic of the preparation strategy of cRGD-functionalized polylipopeptide micelles (cRGD-Lipep-Ms). (PEG-PAPA: poly(ethylene glycol)-b-poly(α-aminopalmitic acid), MMAE: Monomethyl auristatin E, cRGD: cyclic RGD (arginine–glycine–aspartic) peptides, cRGD-Lipep-Ms: cRGD-functionalized polylipopeptide micelles). This figure was adapted by permission from: Molecular Pharmaceutics, 2018, 15, 4854–4861 [173]. c) The illustration of MWCNT/γ-Fe2O3/PEI-PEG-FA/DOX synthesis. This figure was adapted by permission from: Journal of Biotechnology, 2021, 341, 51–62 [174].
Figure 5 a) Preparation route of Pab-functionalized MWCNTs. (DSPE-PEG: Distearoyl-sn-glycero-3- phosphoethanolamine conjugated to polyethylene glycol5000 terminated with a methoxy group, Mal: maleimide, FITC: fluorescein isothiocyanate). This figure was adapted by permission from: ACS applied materials & interfaces, 2018, 10, 33464–33473 [172]. b) A schematic of the preparation strategy of cRGD-functionalized polylipopeptide micelles (cRGD-Lipep-Ms). (PEG-PAPA: poly(ethylene glycol)-b-poly(α-aminopalmitic acid), MMAE: Monomethyl auristatin E, cRGD: cyclic RGD (arginine–glycine–aspartic) peptides, cRGD-Lipep-Ms: cRGD-functionalized polylipopeptide micelles). This figure was adapted by permission from: Molecular Pharmaceutics, 2018, 15, 4854–4861 [173]. c) The illustration of MWCNT/γ-Fe2O3/PEI-PEG-FA/DOX synthesis. This figure was adapted by permission from: Journal of Biotechnology, 2021, 341, 51–62 [174].CC BY-NC-ND · PubMed Central
Figure 6 (a) MTT test using a docetaxel-containing iron oxide/AuNPs nanocarrier on the MCF-7 breast cancer cell line (C: MCF-7 control, DXL: individual docetaxel, P4: mercaptopropyl-modified Fe3O4/PVA particles, P6: Fe3O4/PVA-10%DXL, and P7: Au/Fe3O4/PVA-10%DXL), (b) the ex vivo fluorescence images after the major organs were excised and tetramethylindocarbocyanine iodide (DiR) fluorescence distribution was studied using a Maestro in vivo imaging system, and (c) a schematic presentation of the LSPR heating by AuNPs agglomerated in the magnetically delivered Au/Fe3O4/PVA-10%DXL nanomedicine composite. This figure was adapted by permission from: Small, 2020, 16, 2002733 [102].
Figure 6 (a) MTT test using a docetaxel-containing iron oxide/AuNPs nanocarrier on the MCF-7 breast cancer cell line (C: MCF-7 control, DXL: individual docetaxel, P4: mercaptopropyl-modified Fe3O4/PVA particles, P6: Fe3O4/PVA-10%DXL, and P7: Au/Fe3O4/PVA-10%DXL), (b) the ex vivo fluorescence images after the major organs were excised and tetramethylindocarbocyanine iodide (DiR) fluorescence distribution was studied using a Maestro in vivo imaging system, and (c) a schematic presentation of the LSPR heating by AuNPs agglomerated in the magnetically delivered Au/Fe3O4/PVA-10%DXL nanomedicine composite. This figure was adapted by permission from: Small, 2020, 16, 2002733 [102].CC BY-NC-ND · PubMed Central

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Metadata

Authors
Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., & Maleki, A.
Affiliations
  • Sichuan University (CN)
  • Iran University of Science and Technology (IR)
  • University of Johannesburg (ZA)
Corresponding author
Maleki, Ali
ORCID
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-06
Volume
8
Issue
6
Pages
e09577
ISSN
2405-8440 (ISSN-L)
DOI
10.1016/j.heliyon.2022.e09577
PMC
PMC9189039
OpenAlex
W4281625127
Cited by
79
References
234
Citations by year
2026: 8 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 11
FWCI
1.22
Type
journal article
Language
en
Status
Retracted
Update notices
Open access
Licence
Locations
  • Heliyon (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Sichuan Province Science and Technology Support Program (2022YFH0047)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
nanobioconjugates, targeted drug delivery, cancer therapy, targeting ligands, tumor accumulation, on-demand drug release, polysaccharide nanoparticles, multi-walled carbon nanotubes, halloysite nanotubes, metal-organic frameworks, covalent organic frameworks, gold nanoparticles, silver nanoparticles, polymeric micelles, retracted article

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