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RETRACTED: Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy
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Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.
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“Owing to their biocompatibility and Food and Drug Administration (FDA) approval, AuNPs have become a leading candidate for multiple medical applications.”
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Zhang, W., Taheri‐Ledari, R., Ganjali, F., Mirmohammadi, S. S., Qazi, F. S., Saeidirad, M., Kashtiaray, A., Zarei-Shokat, S., Tian, Y., & Maleki, A. R. (2022) · RSC Advances · doi:10.1039/d2ra06888e · Cited by 220
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Metadata
- Authors
- Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., & Maleki, A.
- Affiliations
- Sichuan University (CN)
- Iran University of Science and Technology (IR)
- University of Johannesburg (ZA)
- Corresponding author
- Maleki, Ali
- ORCID
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 8
- Issue
- 6
- Pages
- e09577
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC9189039
- OpenAlex
- W4281625127
- Cited by
- 79
- References
- 234
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 11
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Sichuan Province Science and Technology Support Program (2022YFH0047)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nanobioconjugates, targeted drug delivery, cancer therapy, targeting ligands, tumor accumulation, on-demand drug release, polysaccharide nanoparticles, multi-walled carbon nanotubes, halloysite nanotubes, metal-organic frameworks, covalent organic frameworks, gold nanoparticles, silver nanoparticles, polymeric micelles, retracted article
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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