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Cited by 6Coconut Research and ApplicationsPhytochemicals and Antioxidant ActivitiesSkin Protection and Aging

Antioxidant and longevity inducing properties of coconut water on human dermal fibroblasts

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Nakorn, Sarun Na, Dokduang, Hasaya, Namwat, Nisana, Klanrit, Poramate, Wangwiwatsin, Arporn, Promraksa, Bundit, Sitthirak, Sirinya, Seaban, Tinnapat +1 more·2024·Heliyon
DOI 10.1016/j.heliyon.2024.e41010PMC PMC11696670
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Abstract

Coconut water is a popular drink in tropical countries and worldwide due to its delicious taste, easy consumption and nutritionally rich properties. Our study aimed to identify bioactive compounds of coconut varieties and their antioxidant as well as longevity effects in 2 different groups of coconuts. These include the bleeding coconut varieties, which are currently most available in the market, namely the Ban Phaeo and Ratchaburi coconut varieties, and the traditional coconut varieties, including Kon-jib and Sampran coconut varieties. Proton nuclear magnetic resonance ( 1 H NMR) was used to profile the metabolites in coconut water which revealed 27 metabolites including sugar, organic acids, fatty acids, flavonoids and phenolic compounds. A multivariate data analysis demonstrated an organic acid and phenolic metabolites as the antioxidant bioactive metabolites in coconut water. In addition, the coconut varieties had higher antioxidant bioactive metabolites compared to traditional coconut varieties, while traditional coconut varieties had higher sugar levels. Furthermore, the varieties containing higher antioxidants bioactive metabolites were chosen to examine the longevity effect on human dermal fibroblasts (HDFs). The results revealed that coconut water can significantly decrease cytosolic oxidation in hydrogen peroxide treated HDFs cell line and mediated longevity of fibroblast cells by modulating the expression of proteins in longevity pathway. Data from our study indicate that coconut water serves as source of antioxidants which can be mediated longevity of dermal cell. Moreover, this study provides the useful information for the coconut water production and distribution business.

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  • Coconut components such as cotyledon, coconut oil, and coconut water exhibit significant antioxidant properties due to their phenolic compounds, tocopherols, and other bioactive metabolites.

    “Coconut components like cotyledon, coconut oil (CO), and coconut water (CW) exhibit significant antioxidant properties due to their phenolic compounds, tocopherols, and other bioactive metabolites (Fig. 4) [73, 118,119,120].”

    From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [119]

    The Results sections on phenolic content and antioxidant activity and on antioxidant-related metabolites report that coconut water contains phenolics and other bioactive metabolites associated with antioxidant activity (page numbers unavailable). The paper does not establish the claimed antioxidant properties of coconut cotyledon or coconut oil, or attribute them to tocopherols. (LLM, conf=0.88)

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Cited by

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Authors
Nakorn, S. N., Dokduang, H., Namwat, N., Klanrit, P., Wangwiwatsin, A., Promraksa, B., Sitthirak, S., Seaban, T., & Loilome, W.
Affiliations
  • Khon Kaen University (TH)
  • Mahasarakham University (TH)
  • Ministry of Public Health (TH)
Corresponding author
Loilome, Watcharin
ORCID
Venue
Heliyon
Publisher
Elsevier BV
Published
2024-12
Volume
10
Issue
24
Pages
e41010
ISSN
2405-8440 (ISSN-L)
DOI
10.1016/j.heliyon.2024.e41010
PMC
PMC11696670
OpenAlex
W4405107783
Cited by
6
References
1
Citations by year
2026: 3 · 2025: 3
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Heliyon (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Thailand Science Research and Innovation
  • Khon Kaen University (IN63331)
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
coconut water, antioxidant activity, cell longevity, human dermal fibroblasts, metabolite profiling, organic acids, phenolic compounds, flavonoids, coconut varieties, hydrogen peroxide stress

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