The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Insulin Resistance and Heart Failure
Open accessAbstract
Insulin resistance and associated reductions in cardiac insulin metabolic signaling is emerging as a major factor for the development of heart failure and assumes more importance because of an epidemic increase in obesity and the cardiorenal metabolic syndrome and our aging population. Major factors contributing to the development of cardiac insulin resistance are oxidative stress, hyperglycemia, hyperlipidemia, dysregulated secretion of adipokines/cytokines and inappropriate activation of renin-angiotensin II-aldosterone system (RAAS) and the sympathetic nervous system. The effects of cardiac insulin resistance are exacerbated by metabolic, endocrine and cytokine alterations associated with systemic insulin resistance. The aggregate of these various alterations leads to an insulin resistant phenotype with metabolic inflexibility, impaired calcium handling, mitochondrial dysfunction and oxidative stress, dysregulated myocardial-endothelial interactions resulting in energy deficiency, impaired diastolic dysfunction, myocardial cell death and cardiac fibrosis. Therefore, understanding the molecular mechanisms linking insulin resistance and heart failure may help to design new and more effective mechanism-based drugs to improve myocardial and systemic insulin resistance.
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Cites
Role of Mitochondrial Dysfunction in Insulin Resistance
Kim, J.-A., Wei, Y., & Sowers, J. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.165472 · Cited by 1,103
Self-citationEndoplasmic reticulum stress, obesity and diabetes
Cnop, M., Foufelle, F., & Velloso, L. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.010 · Cited by 682
Santos, C. X. C., Tanaka, L. Y., Wosniak, J., & Laurindo, F. R. M. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2625 · Cited by 572
Metabolic Mechanisms in Heart Failure
Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 521
Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease
Minamino, T., Komuro, I., & Kitakaze, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.227819 · Cited by 477
Insulin Resistance: the Link Between Obesity and Cardiovascular Disease
Reaven, G. M. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.002 · Cited by 395
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease
Ren, J., Pulakat, L., Whaley-Connell, A., & Sowers, J. R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0663-9 · Cited by 367
Self-citationFalcão-Pires, I., & Leite-Moreira, A. F. (2012) · Heart Failure Reviews · doi:10.1007/s10741-011-9257-z · Cited by 363
Insulin-Resistant Cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.021 · Cited by 351
Boudina, S., Bugger, H., Sena, S., O'Neill, B. T., Zaha, V. G., Ilkun, O., Wright, J. J., Mazumder, P. K., Palfreyman, E., Tidwell, T. J., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.792101 · Cited by 301
Cited by
Association between insulin resistance and the development of cardiovascular disease
Ormazabal, V., Nair, S., Elfeky, O., Aguayo, C., Salomon, C., & Zuñiga, F. A. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0762-4 · Cited by 2,280
Cardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,373
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
The pathophysiology of hypertension in patients with obesity
DeMarco, V. G., Aroor, A. R., & Sowers, J. R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.44 · Cited by 545
Self-citationOvernutrition, mTOR signaling, and cardiovascular diseases
Jia, G., Aroor, A. R., Martinez-Lemus, L. A., & Sowers, J. R. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2014 · Cited by 122
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Metadata
- Authors
- Aroor, A. R., Mandavia, C. H., & Sowers, J. R.
- Venue
- Heart Failure Clinics
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 8
- Issue
- 4
- Pages
- 609-617
- ISSN
- 1551-7136 (ISSN-L)
- OpenAlex
- W67453287
- Cited by
- 252
- References
- 56
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Aroor, A. R., Mandavia, C. H., & Sowers, J. R. (2012). Insulin Resistance and Heart Failure. Heart Failure Clinics. https://doi.org/10.1016/j.hfc.2012.06.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
