Role of Mitochondrial Dysfunction in Insulin Resistance

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The phosphoinositide 3-kinase pathway

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The Pathobiology of Diabetic Complications

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Insulin signalling and the regulation of glucose and lipid metabolism

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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Exercise capacity and mortality among men referred for exercise testing

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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A central role for JNK in obesity and insulin resistance

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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Oxidative damage and mitochondrial decay in aging.

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Understanding the odd science of aging

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms

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High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

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Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

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Gene expression profile of aging and its retardation by caloric restriction

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

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Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

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Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

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Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

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Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide

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MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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Advances in Male Contraception

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

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Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

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Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

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Cardiovascular Actions of Insulin

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

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Etiology of Insulin Resistance

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Prevention of fat-induced insulin resistance by salicylate

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Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.

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Regulation of Fasted Blood Glucose by Resistin

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Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

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Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

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Oxidative capacity and ageing in human muscle

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Lipid oxidation is reduced in obese human skeletal muscle

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Cardiac Steatosis in Diabetes Mellitus: A ¹ H-Magnetic Resonance Spectroscopy Study

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects

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Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

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Relationship Between Insulin Resistance and an Endogenous Nitric Oxide Synthase Inhibitor

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Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

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Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179

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