Long-term outcomes of patients with acute myocardial infarction presenting to regional and remote hospitals
Open accessAbstract
Background Acute myocardial infarction (AMI) has poorer outcomes in disadvantaged populations such as those in regional and remote locations. We compared long-term outcomes associated with presentation to regional or remote hospitals among AMI patients.Methods and results Administrative claims data from New South Wales (27% regional and remote residents) was used to identify patients >18 years admitted to any NSW hospital with a principal diagnosis of AMI (ICD10 codes: I21·0-I21·4) between 01/07/2004 and 30/06/2008. Hospital of presentation location with a population of <250,000 was defined as regional and remote while hospitals with a population >250,000 were deemed urban. Receipt of revascularisation and mortality were analysed and adjusted for age, comorbidities and previous revascularisation. Patients were censored at death or end of the follow-up period (31 December 2009). 39,798 patients were identified with 9,393 (23.6%) regional and remote presenters. In multivariable models, regional and remote presentation was associated with reduced rates of revascularisation (OR 0.30 95%CI 0.28-0.32; p<0.001), no impact on overall mortality (HR 1.04 95%CI 0.99-1.02; p=0.11), but with increased mortality for patients presenting with STEMI (HR 1.14; 95% CI 1.06-1.23; p<0.001). The propensity analysis was consistent with these findings.Conclusions Presentation to a regional and remote hospital was associated with lower revascularisation rates following AMI, but with a higher long-term mortality if presenting with ST segment elevation.
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Rural and remote Australians and New Zealanders experience a higher rate of adverse outcomes from acute myocardial infarction.
“Rural and remote Australians and New Zealanders have a higher rate of adverse outcomes due to acute myocardial infarction, driven by many factors [3,4].”
From Rural and Remote Cardiology During the COVID-19 Pandemic: Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement (2020) · cites this paper as [3]
The Mortality and Sensitivity Analyses sections (pages unavailable) report higher crude mortality for regional and remote NSW patients and higher adjusted mortality for those presenting with STEMI. They found no significant adjusted mortality difference for AMI patients overall, and the study did not examine New Zealanders. (LLM, conf=0.90)
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“Rural and remote Australians and New Zealanders have a higher rate of adverse outcomes due to acute myocardial infarction, driven by many factors [3,4].”
- Authors
- Kotwal, S., Ranasinghe, I., Brieger, D., Clayton, P., Cass, A., & Gallagher, M.
- Affiliations
- The University of Sydney (AU)
- Charles Darwin University (AU)
- Corresponding author
- Kotwal, Sradha
- Venue
- Heart, Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 25
- Issue
- 2
- Pages
- 124-131
- ISSN
- 1443-9506 (ISSN-L)
- OpenAlex
- W1182597593
- Cited by
- 17
- References
- 32
- Citations by year
- 2025: 3 · 2023: 1 · 2021: 2 · 2020: 5 · 2019: 3 · 2017: 1 · 2016: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart Lung and Circulation (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Commonwealth Fund
- Royal Australasian College of Physicians
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- acute myocardial infarction, hospital location, long-term mortality, revascularization, ST-elevation myocardial infarction, health disparities, disadvantaged groups, New South Wales
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, New South Wales, Survival Rate, Disease-Free Survival
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