Arrhythmic burdens in patients with tetralogy of Fallot: a national database study
Abstract
Background Tetralogy of Fallot (TOF) is a common cyanotic congenital heart disease with increasingly recognized late morbidity.Objective The purpose of this study was to explore the long-term outcome by using a national database of Taiwan, a country with national health insurance and easily accessible medical care.Methods Data on TOF patients were retrieved from database records from 2000 to 2010. Complications and therapies were identified by their respective codes.Results We identified 4781 TOF patients (prevalence 0.63/1000 in pediatric patients and 0.06/1000 in adult patients). Arrhythmias were identified in 219 patients (8.3% for adult patients and 2.8% for pediatric patients): 160 tachycardia and 59 bradycardia (4 with tachy-bradycardia syndrome). The occurrence of arrhythmias was associated with higher mortality (excluding cardiac surgical death, 15.6% vs 8.6%, P = .001). Patients with atrial fibrillation were the oldest (median age 44.3 years), followed by those with tachy-bradycardia syndromes (32.4 years) and atrial flutter (31.5 years). The incidence of nonperioperative tachycardia increased with age (1.4%, 1.7%, 3.3%, 5.2%, 10.2%, and 16.9% in age group 0-9, 10-19, 20-29, 30-39, 40-49, and ≥50 years, respectively). Tachycardia therapy (ablation and implantable cardioverter-defibrillator) was administered in 20.4% (annually 2.4%) of patients with nonperioperative tachycardia. In the subgroup born 2000-2010 with complete postnatal data, mortality was 15.1% (296/1960), and 1-, 5-, and 10-year survival was 0.911, 0.826, and 0.788, respectively. Risk of atrioventricular block requiring a pacemaker was 0.6%.Conclusion Arrhythmias are common in TOF patients and increase mortality risk. Medical needs because of tachycardia often appear late in adulthood.
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Occurrence of arrhythmias was associated with higher mortality (15.6% vs 8.6%, P=0.001).
“It was recently reported that the occurrence of arrhythmias was associated with higher mortality (15.6% vs. 8.6%, P ¼ 0.001).389”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [389]
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- Authors
- Wu, M.-H., Lu, C.-W., Chen, H.-C., Chiu, S.-N., Kao, F.-Y., & Huang, S.-K.
- Affiliations
- National Taiwan University (TW)
- Genomics Research Center, Academia Sinica (TW)
- National Health Insurance Administration (TW)
- Corresponding author
- Wu, Mei-Hwan
- Venue
- Heart Rhythm
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 12
- Issue
- 3
- Pages
- 604-609
- ISSN
- 1547-5271 (ISSN-L)
- OpenAlex
- W2038716026
- Cited by
- 64
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 9
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart Rhythm (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- tetralogy of Fallot, cardiac arrhythmias, tachycardia, bradycardia, atrial fibrillation, atrial flutter, mortality, long-term outcomes, atrioventricular block, pacemaker implantation, implantable cardioverter-defibrillator, catheter ablation, survival, congenital heart disease
- MeSH terms
- Adolescent, Adult, Aged, Aging, Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Bradycardia, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Pacemaker, Artificial, Tachycardia, Taiwan, Tetralogy of Fallot, Incidence, Defibrillators, Implantable, Cost of Illness, Young Adult
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