The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aminoglycoside Resistance
Open accessAbstract
Aminoglycoside-producing Actinobacteria are known to protect themselves from their own aminoglycoside metabolites by producing 16S ribosomal RNA methyltransferase (16S-RMTase), which prevents them from binding to the 16S rRNA targets. Ten acquired 16S-RMTases have been reported from gram-negative pathogens. Most of them posttranscriptionally methylate residue G1405 of 16S rRNA resulting in high-level resistance to gentamicin, tobramycin, amikacin, and plazomicin. Strains that produce 16S-RMTase are frequently multidrug-resistant or even extensively drug-resistant. Although the direct clinical impact of high-level aminoglycoside resistance resulting from production of 16S-RMTase is yet to be determined, ongoing spread of this mechanism will further limit treatment options for multidrug-resistant and extensively drug-resistant gram-negative infections.
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Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449
Cited by
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De Oliveira, D. M. P., Forde, B. M., Kidd, T. J., Harris, P. N. A., Schembri, M. A., Beatson, S. A., Paterson, D. L., & Walker, M. J. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00181-19 · Cited by 2,078
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Antibiotic Resistance in Bacteria—A Review
Urban-Chmiel, R., Marek, A., Stępień-Pyśniak, D., Wieczorek, K., Dec, M., Nowaczek, A., & Osek, J. (2022) · Antibiotics · doi:10.3390/antibiotics11081079 · Cited by 580
Kent, A. G., Vill, A. C., Shi, Q., Satlin, M. J., & Brito, I. L. (2020) · Nature Communications · doi:10.1038/s41467-020-18164-7 · Cited by 216
Srinivas, P., Nosrati, M., Zelinskaya, N., Dey, D., Comstock, L. R., Dunham, C. M., & Conn, G. L. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2304128120 · Cited by 20
Metadata
- Authors
- Doi, Y., Wachino, J.-I., & Arakawa, Y.
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 30
- Issue
- 2
- Pages
- 523-537
- ISSN
- 0891-5520 (ISSN-L)
- OpenAlex
- W2408536099
- Cited by
- 341
- References
- 1
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Doi, Y., Wachino, J.-I., & Arakawa, Y. (2016). Aminoglycoside Resistance. Infectious Disease Clinics of North America. https://doi.org/10.1016/j.idc.2016.02.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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