Cited by 1,398Antibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyAntimicrobial Resistance in Staphylococcus

Molecular mechanisms of antibiotic resistance revisited

Darby, Elizabeth M., Trampari, Eleftheria, Siasat, Pauline, Gaya, Maria Solsona, Alav, Ilyas, Webber, Mark A., Blair, Jessica M. A.·2023·Nature Reviews Microbiology

Abstract

Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.

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Crossref · 10.1038/s41579-022-00820-y

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Authors
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A.
Affiliations
  • University of Birmingham (GB)
  • Quadram Institute (GB)
  • University of East Anglia (GB)
Corresponding author
  • Webber, Mark A.
  • Blair, Jessica M. A.
Venue
Nature Reviews Microbiology
Published
2022-11-21
Volume
21
Issue
5
Pages
280-295
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W4309666648
Cited by
1,398
References
235
Citations by year
2026: 369 · 2025: 497 · 2024: 382 · 2023: 146 · 2022: 2 · 2021: 1
FWCI
19.01
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders
  • Medical Research Council (2438035)
  • Biotechnology and Biological Sciences Research Council (BBS/E/F/00044426, BBS/E/F/000PR10349)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
antibiotic resistance, molecular mechanisms of resistance, resistance genes, antibiotic efflux, drug modification
MeSH terms
Anti-Bacterial Agents, Bacteria, Drug Resistance, Microbial, Global Health

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