The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Necrotizing Soft Tissue Infections
Abstract
Necrotizing soft tissue infections occur after traumatic injuries, minor skin lesions, nonpenetrating injuries, natural childbirth, and in postsurgical and immunocompromised patients. Infections can be severe, rapidly progressive, and life threatening. Survivors often endure multiple surgeries and prolonged hospitalization and rehabilitation. Despite subtle nuances that may distinguish one entity from another, clinical approaches to diagnosis and treatment are highly similar. This review describes the clinical and laboratory features of necrotizing soft tissue infections and addresses recommended diagnostic and treatment modalities. It discusses the impact of delays in surgical debridement, antibiotic use, and resuscitation on mortality, and summarizes key pathogenic mechanisms.
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Cites
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621
Stevens, D. L., Bisno, A. L., Chambers, H. F., Dellinger, E. P., Goldstein, E. J. C., Gorbach, S. L., Hirschmann, J. V., Kaplan, S. L., Montoya, J. G., & Wade, J. C. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu296 · Cited by 2,780
Self-citationWong, C.-H., Khin, L.-W., Heng, K.-S., Tan, K.-C., & Low, C.-O. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000129486.35458.7d · Cited by 1,611
Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue Infections
Stevens, D. L., Bisno, A. L., Chambers, H. F., Everett, E. D., Dellinger, P., Goldstein, E. J. C., Gorbach, S. L., Hirschmann, J. V., Kaplan, E. L., Montoya, J. G., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/497143 · Cited by 1,602
Self-citationStevens, D. L., Tanner, M. H., Winship, J., Swarts, R., Ries, K. M., Schlievert, P. M., & Kaplan, E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907063210101 · Cited by 1,216
Self-citationMiller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053
Streptococcal Infections of Skin and Soft Tissues
Bisno, A. L., & Stevens, D. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601253340407 · Cited by 1,001
Self-citationDeterminants of Mortality for Necrotizing Soft-Tissue Infections
McHenry, C. R., Piotrowski, J. J., Petrinic, D., & Malangoni, M. A. (1995) · Annals of Surgery · doi:10.1097/00000658-199505000-00013 · Cited by 888
Invasive Group A Streptococcus Infections
Stevens, D. L. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.1.2 · Cited by 710
Self-citationDarenberg, J., Ihendyane, N., Sjolin, J., Aufwerber, E., Haidl, S., Follin, P., Andersson, J., Norrby-Teglund, A., & The Streptlg Study Group (2003) · Clinical Infectious Diseases · doi:10.1086/376630 · Cited by 573
Research works printed but not linked: 8
- Khamnuan, 2015, Necrotizing fasciitis: epidemiology and clinical predictors for amputation, Int J Gen Med, 8, 195
- Tawa, 2016, Severe sepsis associated with Lemierre's syndrome: a rare but life-threatening disease, Case Rep Crit Care, 2016, 1264283
- Stevens DL, Bryant AE. Severe group A streptococcal infections. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: basic biology to clinical manifestations. NCBI e-book; Bookshelf ID: NBK333425; 2016:PMID: 26866227.
- Stevens, 1988, Recurrent gas gangrene at a site of remote injury: localization due to circulating antitoxin, West J Med, 148, 204
- Stevens DL, Shelly MP, Stiller R, Villasenor-S.A., Bryant AE. Acute reversible cardiomyopathy in patients with streptococcal toxic shock syndrome. Proceedings of the XVIIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, 179. Porto Heli, Greece, 2008. Ref Type: Abstract.
- Clinical and Laboratory Standards Institute. Performance Standards for antimicrobial susceptibility testing; 30th edition. CLSI Supplement M100 2020.
- Leal, 2008, Epidemiology of Clostridium species bacteremia in Calgary, Canada, 2000-2006, J Infect, 57, 198
- Kadri, 2017, Impact of intravenous immunoglobulin on survival in necrotizing fasciitis with vasopressor-dependent shock: a propensity score-matched analysis from 130 US Hospitals, Clin Infect Dis, 64, 877, 10.1093/cid/ciw871 · DOI
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Metadata
- Authors
- Stevens, D. L., Bryant, A. E., & Goldstein, E. J.
- Affiliations
- Boise VA Medical Center (US)
- Idaho State University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Bryant, Amy E.
- ORCID
- Stevens, Dennis L.
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 35
- Issue
- 1
- Pages
- 135-155
- ISSN
- 0891-5520 (ISSN-L)
- OpenAlex
- W3022945043
- Cited by
- 113
- References
- 103
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 22 · 2023: 18 · 2022: 14 · 2021: 7
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Locations
- Infectious Disease Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Current treatment options in infectious diseases/Current treatment options in infectious disease
- Topics
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- necrotizing soft tissue infection, soft tissue necrosis, traumatic injury, immunocompromised patients, postoperative infection, clinical features, laboratory diagnosis, surgical debridement, antibiotic therapy, resuscitation, mortality, pathophysiological mechanisms
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Clostridium, Combined Modality Therapy, Debridement, Female, Gas Gangrene, Hospitalization, Humans, Magnetic Resonance Imaging, Male, Streptococcal Infections, Streptococcus pyogenes, Tomography, X-Ray Computed, Soft Tissue Infections, Fasciitis, Necrotizing, Coinfection
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- Stevens, D. L., Bryant, A. E., & Goldstein, E. J. (2021). Necrotizing Soft Tissue Infections. Infectious Disease Clinics of North America. https://doi.org/10.1016/j.idc.2020.10.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
