Gastrointestinal variant of Lemierre’s syndrome complicating ruptured appendicitis
Open accessAbstract
Fusobacterium necrophorum is a non-spore-forming, obligate anaerobic, filamentous, gramnegative bacillus that frequently colonizes the human oral cavity, respiratory tract, and gastrointestinal tract. Fusobacterium species have rarely been implicated in cases of gastrointestinal variant of Lemierre's syndrome. We describe a case of F. necrophorum bacteremia associated with suppurative porto-mesenteric vein thrombosis (PVT) following acute ruptured appendicitis. In addition, we list the documented twelve cases of Fusobacterium pylephlebitis. Recanalization of the porto-mesenteric veins and relief of the extrahepatic portal hypertension were achieved with early empiric antibiotic and local thrombolytic therapy. Our patient's case underscores the importance of recognizing Fusobacterium bacteremia as a possible cause of suppurative PVT after disruption of the gastrointestinal mucosa following an acute intraabdominal infectious process. Early treatment of this condition using anticoagulation and endovascular thrombolysis as adjunctive therapies may prevent PVT complications.
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Portal vein thrombosis and mesenteric vein thrombosis can be seen with celiac disease, appendicitis, pancreatitis, and liver cirrhosis and hepatocellular cancer.
“Portal vein thrombosis and mesenteric vein thrombosis can be seen with celiac disease [2], appendicitis [3], pancreatitis [4], and, in particular, liver cirrhosis and hepatocellular cancer [5].”
From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [3]
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Acute mesenteric ischemia in COVID-19 patients
Serban, D., Tribus, L. C., Vancea, G., Stoian, A. P., Dascalu, A. M., Suceveanu, A. I., Tanasescu, C., Costea, A. C., Tudosie, M. S., Tudor, C., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010200 · Cited by 46 · see citing works
- Authors
- Akhrass, F. A., Abdallah, L., Berger, S., & Sartawi, R.
- Affiliations
- Pikeville Medical Center (US)
- Corresponding author
- Akhrass, Fadi Al
- Venue
- IDCases
- Publisher
- Elsevier BV
- Published
- 2015
- Volume
- 2
- Issue
- 3
- Pages
- 72-76
- ISSN
- 2214-2509 (ISSN-L)
- PMC
- PMC4712199
- OpenAlex
- W1832973442
- Cited by
- 14
- References
- 22
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- IDCases (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- Lemierre's syndrome, Fusobacterium necrophorum, ruptured appendicitis, bacteremia, thrombolysis, anticoagulation, endovascular thrombolysis, extrahepatic portal hypertension
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