Clinical and laboratory features of human dirofilariasis in Russia
Open accessAbstract
The article presents the results of the prospective study of 266 patients with dirofilariasis who received medical and diagnostic assistance in Rostov Scientific Research Institute of Microbiology and Parasitology in Rostov-on-Don, Russia from 2000 to 2016. We have assessed the features of the dynamics of epidemiology of this infection in several territories of the Russian Federation, depending on the social structure of patients. Immature females of dirofilaria were found most commonly in humans (82.9 ± 2.6%), the proportion of maturity females and adult males of worms respectively was 10.5 ± 2.1% and 0.9 ± 0.6%. All mature worms were localized inside a capsule. Peripheral blood eosinophilia was detected only in patients with the migration of helminths (19 of 116 persons – 16.4%). Blood samples of patients examined by the method of concentration in 3% acetic acid for detection of microfilariae, showed negative result in all patients. Our data are consistent with the opinion of KI Skriabin about that human as «dual facultative host» for dirofiliaria. It is rare that parasite in human body is able to develop to the imago stage (according to our observations – 11.4%). The immune response to invasion by dirofiliaria in human is manifested as dense connective tissue which forms a capsule. According to our study the rare cases (22) of detection the sexual mature D. repens (10.4%) were localized inside the capsule. Observations of patients with D. repens infection allowed concluding that human for this helminth is «a biological deadend».
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In 22 of 24 dirofilariasis patients in Russia who could not undergo surgery because of active migration of parasites, albendazole (800 mg daily for 5 days) in combination with doxycycline (200 mg daily for 5 days) gave good results.
“Surgery was not possible in 24 of 266 dirofilariasis patients in Russia because of active migration of parasites in tissues, and in such cases albendazole (800 mg daily for 5 days) in combination with doxycycline (200 mg daily for 5 days) were prescribed for conservative treatment in 22 of the 24 patients with good results [250]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [250]
The Results report that active parasite migration prevented surgery in 24 adults and give the stated five-day albendazole and doxycycline doses. Two patients received albendazole alone because they could not tolerate doxycycline, leaving 22 who received the combination. The paper reports treatment failure in those two patients but does not explicitly report good outcomes for the other 22. (LLM, conf=0.87)
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Cites
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Recent advances on Dirofilaria repens in dogs and humans in Europe
Capelli, G., Genchi, C., Baneth, G., Bourdeau, P., Brianti, E., Cardoso, L., Danesi, P., Fuehrer, H.-P., Giannelli, A., Ionică, A. M., et al. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-3205-x · Cited by 298 · see citing works
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Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
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Pupić-Bakrač, A., Pupić-Bakrač, J., Beck, A., Jurković, D., Polkinghorne, A., & Beck, R. (2021) · One Health · doi:10.1016/j.onehlt.2021.100306 · Cited by 58 · see citing works
Human Dirofilariasis in Bulgaria between 2009 and 2018
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- Authors
- Ermakova, L., Nagorny, S., Pshenichnaya, N., Ambalov, Y., & Boltachiev, K.
- Affiliations
- Rostov State Medical University (RU)
- Rostov Research Institute of Microbiology and Parasitology (RU)
- North Caucasian State Humanitarian Technological Academy (RU)
- Corresponding author
- Pshenichnaya, Natalia
- Venue
- IDCases
- Publisher
- Elsevier BV
- Published
- 2017
- Volume
- 9
- Pages
- 112-115
- ISSN
- 2214-2509 (ISSN-L)
- PMC
- PMC5537165
- OpenAlex
- W2737554082
- Cited by
- 42
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 5 · 2020: 12 · 2019: 3 · 2018: 5 · 2017: 1
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- IDCases (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Keywords
- dirofilariasis, Dirofilaria repens, Dirofilaria, human filariasis, eosinophilia, microfilariae, connective tissue capsule
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