In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii
Abstract
Sargassum swartzii, a marine brown algae with wide range of biological properties belongs to the family Sargassaceae. Bioactive fucoidan fractions (CFF, FF1 and FF2) were isolated from S. swartzii and characterized by linear gradient anion-exchange chromatography and FT-IR. The characterized fucoidan fractions contained mainly sugars, sulfate and uronic acid. In the present study, anti-HIV-1 property of the fucoidan fractions was investigated. Fraction FF2 was found to exhibit significant anti-HIV-1 activity at concentrations of 1.56 and 6.25 μg/ml as observed by >50% reduction in HIV-1 p24 antigen levels and reverse transcriptase activity. Fucoidan fractions have no cytotoxic effects on PBMCs at the concentration range of 1.56-1000 μg/ml. These results suggest that fucoidan fractions could have inhibitory activity against HIV and has potential as an anti-HIV-1 agent.
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Slightly acidic HCl solutions have been used for macroalgal polysaccharide extraction.
“Slightly acidic solutions, i.e. low molarity solutions of HCl have also been described”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Dinesh et al., 2016
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References 34 · Cited by 110
- Authors
- Dinesh, S., Menon, T., Hanna, L. E., Suresh, V., Sathuvan, M., & Manikannan, M.
- Affiliations
- University of Madras (IN)
- National Institute of Research in Tuberculosis (IN)
- Annamalai University (IN)
- Sathyabama Institute of Science and Technology (IN)
- Corresponding author
- Menon, Thangam
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 82
- Pages
- 83-88
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2192428794
- Cited by
- 110
- References
- 34
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 8 · 2023: 14 · 2022: 15 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 4
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- NIRT Institutional Scholarship Repository (National Institute of Research in Tuberculosis) (acceptedVersion)
- Funders
- National Institute for Research in Tuberculosis
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- fucoidan, Sargassum swartzii, anti-HIV-1 activity, HIV-1 reverse transcriptase inhibition, marine brown algae, sulfated polysaccharides, uronic acid, cytotoxicity, peripheral blood mononuclear cells, p24 antigen
- MeSH terms
- Cells, Cultured, Humans, Leukocytes, Mononuclear, Microbial Sensitivity Tests, Molecular Weight, Polysaccharides, Virus Replication, HIV-1, HIV Core Protein p24, Spectroscopy, Fourier Transform Infrared, Anti-HIV Agents, Sargassum, HIV Reverse Transcriptase
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