Digestibility of sulfated polysaccharide from the brown seaweed Ascophyllum nodosum and its effect on the human gut microbiota in vitro
Abstract
Sulfated polysaccharides from marine algae exhibit various bioactivities with potential benefits for human health and well-being. In this study, the in vitro digestibility and fermentability of polysaccharides from the brown seaweed Ascophyllum nodosum (AnPs) were examined, and the effects of AnPs on gut microbiota were determined using high-throughput sequencing technology. Salivary amylase, artificial gastric juice, and intestinal juice had no effect on AnPs, but the molecular weight of AnPs and reducing sugar decreased significantly after fermentation by gut microbiota. AnPs significantly modulated the composition of the gut microbiota; in particular, they increased the relative abundance of Bacteroidetes and Firmicutes, suggesting the potential for AnPs to decrease the risk of obesity. Furthermore, the total SCFA content after fermentation increased significantly. These results suggest that AnPs have potential uses as functional food components to improve human gut health.
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Polysaccharides obtained from Ascophyllum nodosum increase the quantity of Bacteroidetes and Firmicutes, suggesting potential to decrease the risk of obesity.
“Recently, it was reported that polysaccharides obtained from the brown alga Ascophyllum nodosum increase the quantity of Bacteroidetes and Firmicutes, suggesting the potential of Ascophyllum nodosum polysaccharides to decrease the risk of obesity.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [117]
Ascophyllum nodosum polysaccharides have potential uses as functional food components to improve human gut health.
“These results suggest that Ascophyllum nodosum polysaccharides have potential uses as functional food components to improve human gut health [117].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [117]
Total short chain fatty acids content after fermentation of Ascophyllum nodosum polysaccharides increased significantly.
“Furthermore, the total short chain fatty acids content after fermentation increased significantly.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [117]
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References 50 · Cited by 140
- Authors
- Chen, L., Xu, W., Chen, D., Chen, G., Liu, J., Zeng, X., Shao, R., & Zhu, H.
- Affiliations
- Nanjing Tech University (CN)
- Yancheng Institute of Technology (CN)
- Nanjing Agricultural University (CN)
- Corresponding author
- Xu, Wei
- Zhu, Hongjun
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 112
- Pages
- 1055-1061
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2790953887
- Cited by
- 140
- References
- 50
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 13 · 2023: 16 · 2022: 27 · 2021: 23 · 2020: 15 · 2019: 13 · 2018: 5
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Higher Education Institutions of China (17KJA530006)
- Yancheng Institute of Technology (K2016-07)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- sulfated polysaccharides, Ascophyllum nodosum, brown algae, in vitro digestibility, gut microbiota, fermentation, short-chain fatty acids, Bacteroidetes, Firmicutes, obesity, functional foods, marine algae
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Chromatography, High Pressure Liquid, Fatty Acids, Fermentation, Humans, Polysaccharides, Sulfates, Ascophyllum
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