The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Fabrication of alginate microspheres for drug delivery: A review
Abstract
Alginate microspheres (AMs) have received much attention as a novel drug delivery system owing to various advantages of alginate such as inexpensiveness, nontoxicity, biocompatibility and biodegradability. The well-designed fabrication method is essential to achieve desired AMs suitable for specific drug delivery system. Reports on AMs preparation techniques have increased rapidly in the last decade. A number of synthesis parameters have been investigated for the improvement of physical, chemical and biological properties of AMs. Hence, this review summarizes the work to date on the fabrication techniques of AMs for drug delivery system, including spray-drying, extrusion and emulsification/gelation technique. Besides, the influence of various factors such as alginate concentration, oil phase, surfactant, cross-linker concentrations, cross-linking time, stirring speed, model drug and drug content on the morphologies, properties and encapsulation efficiency (EE) of AMs via extrusion and emulsification/gelation technique are summarized. Before embarking on the development of any drug delivery system, a thorough understanding of drug release mechanism and factors that impact the drug release profile are essential, which are also covered in this review.
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Cites
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Cited by
Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
Gheorghita Puscaselu, R., Lobiuc, A., Dimian, M., & Covasa, M. (2020) · Polymers · doi:10.3390/polym12102417 · Cited by 470
Ghumman, S. A., Mahmood, A., Noreen, S., Rana, M., Hameed, H., Ijaz, B., Hasan, S., Aslam, A., & ur Rehman, M. F. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.103811 · Cited by 54
Tang, L., Liu, C., Liu, X., Zhang, L., Fan, B., Wang, B., & Wang, F. (2025) · Food Chemistry: X · doi:10.1016/j.fochx.2025.102311 · Cited by 32
Noureen, S., Noreen, S., Ghumman, S. A., Batool, F., Hameed, H., Hasan, S., Noreen, F., Elsherif, M. A., & Bukhari, S. N. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050916 · Cited by 28
Encapsulation of curcumin in alginate microbeads(AMB) for control release of curcumin
Shaikh, S. A. M., & Barik, A. (2023) · Journal of Chemical Sciences · doi:10.1007/s12039-023-02159-0 · Cited by 21
Metadata
- Authors
- Uyen, N. T. T., Hamid, Z. A. A., Tram, N. X. T., & Ahmad, N.
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 153
- Pages
- 1035-1046
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2990134901
- Cited by
- 353
- References
- 78
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Uyen, N. T. T., Hamid, Z. A. A., Tram, N. X. T., & Ahmad, N. (2020). Fabrication of alginate microspheres for drug delivery: A review. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2019.10.233
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
