Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 8,095

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Alginate: Properties and biomedical applications

Open access
Lee, Kuen Yong, Mooney, David J.·2012·Progress in Polymer Science

Abstract

Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications to date, as these gels retain structural similarity to the extracellular matrices in tissues and can be manipulated to play several critical roles. This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.progpolymsci.2011.06.003

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 176

  1. Huebsch, 2009, Inspiration and application in the evolution of biomaterials, Nature, 462, 426, 10.1038/nature08601 · DOI · Paper page
  2. Williams, 2009, On the nature of biomaterials, Biomaterials, 30, 5897, 10.1016/j.biomaterials.2009.07.027 · DOI · Paper page
  3. Gombotz, 1998, Protein release from alginate matrices, Adv Drug Delivery Rev, 31, 267, 10.1016/S0169-409X(97)00124-5 · DOI · Paper page
  4. Langer, 1993, Tissue engineering, Science, 260, 920, 10.1126/science.8493529 · DOI · Paper page
  5. Lee, 2001, Hydrogels for tissue engineering, Chem Rev, 101, 1869, 10.1021/cr000108x · DOI · Paper page
  6. Smidsrod, 1990, Alginate as immobilization matrix for cells, Trend Biotechnol, 8, 71, 10.1016/0167-7799(90)90139-O · DOI · Paper page
  7. Qin, 2008, Alginate fibres: an overview of the production processes and applications in wound management, Polym Int, 57, 171, 10.1002/pi.2296 · DOI · Paper page
  8. Remminghorst, 2006, Bacterial alginates: from biosynthesis to applications, Biotechnol Lett, 28, 1701, 10.1007/s10529-006-9156-x · DOI · Paper page
  9. Fischer, 1955, Die polyuronsauren der braunalgen-(kohlenhydrate der algen-I), Z Physiol Chem, 302, 186, 10.1515/bchm2.1955.302.1-2.186 · DOI · Paper page
  10. Haug, 1959, Fractionation of alginic acid, Acta Chem Scand, 13, 601, 10.3891/acta.chem.scand.13-0601 · DOI
  11. Tonnesen, 2002, Alginate in drug delivery systems, Drug Dev Ind Pharm, 28, 621, 10.1081/DDC-120003853 · DOI · Paper page
  12. Hay, 2010, Bacterial biosynthesis of alginates, J Chem Technol Biotechnol, 85, 752, 10.1002/jctb.2372 · DOI · Paper page
  13. Rinaudo, 1992, On the abnormal exponents aη and aD in Mark–Houwink type equations for wormlike chain polysaccharides, Polym Bull, 27, 585, 10.1007/BF00300608 · DOI
  14. LeRoux, 1999, Compressive and shear properties of alginate gel: effects of sodium ions and alginate concentration, J Biomed Mater Res, 47, 46, 10.1002/(SICI)1097-4636(199910)47:1<46::AID-JBM6>3.0.CO;2-N · DOI · Paper page
  15. Kong, 2003, Designing alginate hydrogels to maintain viability of immobilized cells, Biomaterials, 24, 4023, 10.1016/S0142-9612(03)00295-3 · DOI · Paper page
  16. Kong, 2002, Decoupling the dependence of rheological/mechanical properties of hydrogels from solids concentration, Polymer, 43, 6239, 10.1016/S0032-3861(02)00559-1 · DOI · Paper page
  17. Otterlei, 1991, Induction of cytokine production from human monocytes stimulated with alginate, J Immunother, 10, 286, 10.1097/00002371-199108000-00007 · DOI · Paper page
  18. Zimmermann, 1992, Production of mitogen contamination free alginates with variable ratios of mannuronic to guluronic acid by free flow electrophoresis, Electrophoresis, 13, 269, 10.1002/elps.1150130156 · DOI · Paper page
  19. Orive, 2002, Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates, Biomaterials, 23, 3825, 10.1016/S0142-9612(02)00118-7 · DOI · Paper page
  20. Lee, 2009, Local and sustained vascular endothelial growth factor delivery for angiogenesis using an injectable system, Pharm Res, 26, 1739, 10.1007/s11095-009-9884-4 · DOI
  21. Pelletier, 2001, Amphiphilic derivatives of sodium alginate and hyaluronate for cartilage repair: rheological properties, J Biomed Mater Res, 54, 102, 10.1002/1097-4636(200101)54:1<102::AID-JBM12>3.0.CO;2-1 · doi:10.1002/1097-4636(200101)54:1<102::aid-jbm12>3.0.co;2-1
  22. Leonard, 2004, Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties, J Control Release, 98, 395, 10.1016/j.jconrel.2004.05.009 · DOI · Paper page
  23. Vallee, 2009, Synthesis and rheological properties of hydrogels based on amphiphilic alginate-amide derivatives, Carbohydr Res, 344, 223, 10.1016/j.carres.2008.10.029 · DOI
  24. Yang, 2007, Amphiphilic cholesteryl grafted sodium alginate derivative: Synthesis and self-assembly in aqueous solution, Carbohydr Polym, 68, 218, 10.1016/j.carbpol.2006.12.020 · DOI
  25. Colinet, 2009, New amphiphilic modified polysaccharides with original solution behaviour in salt media, Carbohydr Polym, 75, 454, 10.1016/j.carbpol.2008.08.002 · DOI
  26. Yao, 2010, Hydrophobic modification of sodium alginate and its application in drug controlled release, Bioprocess Biosyst Eng, 33, 457, 10.1007/s00449-009-0349-2 · DOI
  27. Lehenkari, 1999, Single integrin molecule adhesion forces in intact cells measured by atomic force microscopy, Biochem Biophys Res Commun, 259, 645, 10.1006/bbrc.1999.0827 · DOI · Paper page
  28. Koo, 2002, Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus, J Cell Sci, 115, 1423, 10.1242/jcs.115.7.1423 · DOI · Paper page
  29. Lee, 2008, Quantifying interactions between cell receptors and adhesion ligand-modified polymers in solution, Macromol Biosci, 8, 140, 10.1002/mabi.200700169 · DOI
  30. Alsberg, 2001, Cell-interactive alginate hydrogels for bone tissue engineering, J Dental Res, 80, 2025, 10.1177/00220345010800111501 · DOI · Paper page
  31. Dhoot, 2004, Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth, J Biomed Mater Res Part A, 71, 191, 10.1002/jbm.a.30103 · DOI
  32. Sakiyama-Elbert, 2001, Functional biomaterials: design of novel biomaterials, Ann Rev Mater Res, 31, 183, 10.1146/annurev.matsci.31.1.183 · DOI · Paper page
  33. Varghese, 2006, Hydrogels for musculoskeletal tissue engineering, Adv Polym Sci, 203, 95, 10.1007/12_072 · DOI · Paper page
  34. Lee, 2007, Polymeric protein delivery systems, Progr Polym Sci, 32, 669, 10.1016/j.progpolymsci.2007.04.001 · DOI · Paper page
  35. Grant, 1973, Biological interactions between polysaccharides and divalent cations – egg-box model, FEBS Lett, 32, 195, 10.1016/0014-5793(73)80770-7 · DOI · Paper page
  36. Crow, 2006, Release of bovine serum albumin from a hydrogel-cored biodegradable polymer fiber, Biopolymers, 81, 419, 10.1002/bip.20442 · doi:10.1002/bip.20442
  37. Kuo, 2001, Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. structure, gelation rate and mechanical properties, Biomaterials, 22, 511, 10.1016/S0142-9612(00)00201-5 · DOI · Paper page
  38. Augst, 2006, Alginate hydrogels as biomaterials, Macromol Biosci, 6, 623, 10.1002/mabi.200600069 · DOI · Paper page
  39. Drury, 2004, The tensile properties of alginate hydrogels, Biomaterials, 25, 3187, 10.1016/j.biomaterials.2003.10.002 · DOI · Paper page
  40. Suzuki, 1998, Evaluation of a novel alginate gel dressing, J Biomed Mater Res, 39, 317, 10.1002/(SICI)1097-4636(199802)39:2<317::AID-JBM20>3.0.CO;2-8 · DOI
  41. Zhao, 2010, Stress-relaxation behavior in gels with ionic and covalent crosslinks, J Appl Phys, 107, 10.1063/1.3343265 · DOI · Paper page
  42. Eiselt, 1999, Rigidity of two-component hydrogels prepared from alginate and poly(ethylene glycol)-diamines, Macromolecules, 32, 5561, 10.1021/ma990514m · DOI · Paper page
  43. Lee, 2000, Controlling mechanical and swelling properties of alginate hydrogels independently by cross-linker type and crosslinking density, Macromolecules, 33, 4291, 10.1021/ma9921347 · DOI · Paper page
  44. Lee, 2004, Controlled degradation of hydrogels using multifunctional cross-linking molecules, Biomaterials, 25, 2461, 10.1016/j.biomaterials.2003.09.030 · DOI · Paper page
  45. Smeds, 2001, Photocrosslinkable polysaccharides for in situ hydrogel formation, J Biomed Mater Res, 54, 115, 10.1002/1097-4636(200101)54:1<115::AID-JBM14>3.0.CO;2-Q · DOI · Paper page
  46. Tanaka, 1972, Photosensitivity of polyvinylesters of substituted cinnamylideneacetic acids, J Polym Sci, 10, 3279, 10.1002/pol.1972.170101114 · doi:10.1002/pol.1972.170101114
  47. Lu, 2000, Cell encapsulation with alginate and α-phenoxycinnamylidene-acetylated poly(allylamine), Biotechnol Bioeng, 70, 479, 10.1002/1097-0290(20001205)70:5<479::AID-BIT1>3.0.CO;2-E · doi:10.1002/1097-0290(20001205)70:5<479::aid-bit1>3.0.co;2-e
  48. Roy, 2010, Future perspectives and recent advances in stimuliresponsive materials, Progr Polym Sci, 35, 278, 10.1016/j.progpolymsci.2009.10.008 · DOI · Paper page
  49. Rzaev, 2007, Functional copolymers of N-isopropylacrylamide for bioengineering applications, Progr Polym Sci, 32, 534, 10.1016/j.progpolymsci.2007.01.006 · DOI · Paper page
  50. Zhao, 2010, Synthesis and characterization of thermo-sensitive semi-IPN hydrogels based on poly(ethylene glycol)-co-poly(epsilon-caprolactone) macromer, N-isopropylacrylamide, and sodium alginate, Carbohydr Res, 345, 425, 10.1016/j.carres.2009.11.014 · doi:10.1016/j.carres.2009.11.014
  51. Lee, 2003, Hydrogel formation via cell cross-linking, Adv Mater, 15, 1828, 10.1002/adma.200305406 · DOI
  52. Drury, 2005, Cellular cross-linking of peptide modified hydrogels, J Biomech Eng: Trans ASME, 127, 220, 10.1115/1.1865194 · DOI
  53. Al-Shamkhani, 1995, Radioiodination of alginate via covalently-bound tyrosinamide allows monitoring of its fate in vivo, J Bioact Compat Polym, 10, 4, 10.1177/088391159501000102 · DOI
  54. Bouhadir, 2001, Degradation of partially oxidized alginate and its potential application for tissue engineering, Biotechnol Prog, 17, 945, 10.1021/bp010070p · DOI · Paper page
  55. Lee, 2000, Degradation behavior of covalently cross-inked poly(aldehyde guluronate) hydrogels, Macromolecules, 33, 97, 10.1021/ma991286z · DOI
  56. Kong, 2004, Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution, Biomacromolecules, 5, 1720, 10.1021/bm049879r · DOI · Paper page
  57. Kong, 2004, Controlling degradation of hydrogels via the size of cross-linked junctions, Adv Mater, 16, 1917, 10.1002/adma.200400014 · DOI
  58. Boontheekul, 2005, Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution, Biomaterials, 26, 2455, 10.1016/j.biomaterials.2004.06.044 · DOI · Paper page
  59. Maiti, 2009, Adipic acid dihydrazide treated partially oxidized alginate beads for sustained oral delivery of flurbiprofen, Pharm Develop Technol, 14, 461, 10.1080/10837450802712658 · DOI
  60. Bouhadir, 2001, Hydrogels for combination delivery of antineoplastic agents, Biomaterials, 22, 2625, 10.1016/S0142-9612(01)00003-5 · DOI
  61. Colinet, 2009, New amphiphilic and pH-sensitive hydrogel for controlled release of a model poorly water-soluble drug, Eur J Pharm Biopharm, 73, 345, 10.1016/j.ejpb.2009.07.008 · DOI
  62. Zhang, 2010, Alginate microsphere filled with carbon nanotube as drug carrier, Int J Biol Macromol, 47, 389, 10.1016/j.ijbiomac.2010.06.003 · DOI
  63. Sandford, 1991, Biomedical application of high-purity chitosan, vol. 467, 430
  64. Rinaudo, 2006, Chitin and chitosan: properties and applications, Progr Polym Sci, 31, 603, 10.1016/j.progpolymsci.2006.06.001 · DOI · Paper page
  65. Lucinda-Silva, 2010, Alginate-chitosan systems: in vitro controlled release of triamcinolone and in vivo gastrointestinal transit, Carbohydr Polym, 81, 260, 10.1016/j.carbpol.2010.02.016 · DOI
  66. Wang, 2010, A novel pH-sensitive magnetic alginate74 chitosan beads for albendazole delivery, Drug Dev Ind Pharm, 36, 867, 10.3109/03639040903567117 · DOI
  67. Lira, 2009, Preparation and characterization of chitosan-treated alginate microparticles incorporating all-trans retinoic acid, J Microencapsul, 26, 243, 10.1080/02652040802305105 · DOI
  68. Ishak, 2007, Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti-Helicobacter pylori therapy, J Control Release, 119, 207, 10.1016/j.jconrel.2007.02.012 · DOI
  69. Chang, 2010, Nanoparticles incorporated in pH-sensitive hydrogels as amoxicillin delivery for eradication of Helicobacter pylori, Biomacromolecules, 11, 133, 10.1021/bm900985h · DOI
  70. Lee, 2003, Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice, J Control Release, 87, 49, 10.1016/S0168-3659(02)00349-8 · DOI
  71. Silva, 2010, Effects of VEGF temporal and spatial presentation on angiogenesis, Biomaterials, 31, 1235, 10.1016/j.biomaterials.2009.10.052 · DOI · Paper page
  72. Wells, 2007, Extended release of high pI proteins from alginate microspheres via a novel encapsulation technique, Eur J Pharm Biopharm, 65, 329, 10.1016/j.ejpb.2006.10.018 · DOI
  73. Gao, 2009, Preparation of oxidized sodium alginate-graftpoly((2-dimethylamino) ethyl methacrylate) gel beads and in vitro controlled release behavior of BSA, Int J Pharm, 371, 16, 10.1016/j.ijpharm.2008.12.013 · DOI
  74. Chan, 2010, Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics, Biomaterials, 31, 9040, 10.1016/j.biomaterials.2010.07.111 · DOI
  75. Silva, 2006, Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation, Eur J Pharm Sci, 29, 148, 10.1016/j.ejps.2006.06.008 · DOI
  76. Wang, 2007, Silk coatings on PLGA and alginate microspheres for protein delivery, Biomaterials, 28, 4161, 10.1016/j.biomaterials.2007.05.036 · DOI
  77. Lee, 2009, Injectable microsphere/hydrogel combination systems for localized protein delivery, Macromol Biosci, 9, 671, 10.1002/mabi.200800317 · DOI
  78. Lee, 2009, Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction, J Control Release, 137, 196, 10.1016/j.jconrel.2009.04.008 · DOI
  79. Boateng, 2008, Wound healing dressings and drug delivery systems: a review, J Pharm Sci, 97, 2892, 10.1002/jps.21210 · DOI · Paper page
  80. Queen, 2004, A dressing history, Int Wound J, 1, 59, 10.1111/j.1742-4801.2004.0009.x · DOI
  81. Balakrishnan, 2006, Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situforming hydrogel wound dressing based on oxidized alginate and gelatin, Biomaterials, 27, 1355, 10.1016/j.biomaterials.2005.08.021 · DOI
  82. Rabbany, 2010, Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing, Cell Transplant, 19, 399, 10.3727/096368909X481782 · DOI
  83. Wiegand, 2009, Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate, Wound Repair Regener, 17, 511, 10.1111/j.1524-475X.2009.00503.x · DOI · Paper page
  84. Agren, 1999, Zinc in wound repair, Arch Dermatol, 135, 1273, 10.1001/archderm.135.10.1273-a · doi:10.1001/archderm.135.10.1273-a
  85. Murakami, 2010, Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings, Biomaterials, 31, 83, 10.1016/j.biomaterials.2009.09.031 · DOI · Paper page
  86. Rowley, 2002, Biomaterials to spatially regulate cell fate, Adv Mater, 14, 886, 10.1002/1521-4095(20020618)14:12<886::AID-ADMA886>3.0.CO;2-I · DOI
  87. Jeon, 2010, Biodegradable, photocrosslinked alginate hydrogels with independently tailorable physical properties and cell adhesivity, Tissue Eng Part A, 16, 2915, 10.1089/ten.tea.2010.0096 · DOI
  88. Degala, 2011, Chondrocyte calcium signaling in response to fluid flow is regulated by matrix adhesion in 3-D alginate scaffolds, Arch Biochem Biophys, 505, 112, 10.1016/j.abb.2010.08.003 · DOI
  89. Evangelista, 2007, Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix, Biomaterials, 28, 3644, 10.1016/j.biomaterials.2007.04.028 · DOI
  90. Kreeger, 2006, The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels, Biomaterials, 27, 714, 10.1016/j.biomaterials.2005.06.016 · DOI · Paper page
  91. Hsiong, 2008, Differentiation stage alters matrix control of stem cells, J Biomed Mater Res Part A, 85, 145, 10.1002/jbm.a.31521 · DOI
  92. Wang, 2003, Evaluation of sodium alginate for bone marrow cell tissue engineering, Biomaterials, 24, 3475, 10.1016/S0142-9612(03)00167-4 · DOI · Paper page
  93. Bidarra, 2010, Immobilization of human mesenchymal stem cells within RGD-grafted alginate microspheres and assessment of their angiogenic potential, Biomacromolecules, 11, 1956, 10.1021/bm100264a · DOI
  94. Rowley, 1999, Alginate hydrogels as synthetic extracellular matrix materials, Biomaterials, 20, 45, 10.1016/S0142-9612(98)00107-0 · DOI · Paper page
  95. Lee, 2010, The effect of spacer arm length of an adhesion ligand coupled to an alginate gel on the control of fibroblast phenotype, Biomaterials, 31, 5545, 10.1016/j.biomaterials.2010.03.063 · DOI
  96. Lee, 2004, Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation, Nano Lett, 4, 1501, 10.1021/nl0493592 · DOI
  97. Comisar, 2006, Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels, Biomaterials, 27, 2322, 10.1016/j.biomaterials.2005.10.037 · doi:10.1016/j.biomaterials.2005.10.037
  98. Comisar, 2007, nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach, Biomaterials, 28, 4409, 10.1016/j.biomaterials.2007.06.018 · DOI
  99. Connelly, 2007, Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels, Biomaterials, 28, 1071, 10.1016/j.biomaterials.2006.10.006 · DOI · Paper page
  100. Hsiong, 2009, Cyclic arginine–glycine–aspartate peptides enhance three-dimensional stem cell osteogenic differentiation, Tissue Eng Part A, 15, 263, 10.1089/ten.tea.2007.0411 · DOI
  101. Bogdanowich-Knipp, 1999, Solution stability of linear vs. cyclic RGD peptides, J Pept Res, 53, 530, 10.1034/j.1399-3011.1999.00052.x · DOI
  102. Kumagai, 1991, Effect of cyclic RGD peptide on cell adhesion and tumor metastasis, Biochem Biophys Res Commun, 177, 74, 10.1016/0006-291X(91)91950-H · DOI
  103. Liu, 2006, Radiolabeled multimeric cyclic RGD peptides as integrin αvβ3 targeted radiotracers for tumor imaging, Mol Pharm, 3, 472, 10.1021/mp060049x · DOI · Paper page
  104. Huebsch, 2010, Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate, Nat Mater, 9, 518, 10.1038/nmat2732 · DOI · Paper page
  105. Fischbach, 2009, Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement, Proc Natl Acad Sci USA, 106, 399, 10.1073/pnas.0808932106 · DOI · Paper page
  106. Kong, 2005, FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness, Proc Natl Acad Sci USA, 102, 4300, 10.1073/pnas.0405873102 · DOI · Paper page
  107. Kong, 2005, Non-viral gene delivery regulated by stiffness of cell adhesion substrates, Nat Mater, 4, 460, 10.1038/nmat1392 · DOI · Paper page
  108. Kong, 2006, Quantifying the relation between adhesion ligandreceptor bond formation and cell phenotype, Proc Natl Acad Sci USA, 103, 18534, 10.1073/pnas.0605960103 · DOI
  109. Carmeliet, 2005, Angiogenesis in life, disease and medicine, Nature, 438, 932, 10.1038/nature04478 · DOI · Paper page
  110. Cao, 2007, Spatiotemporal control over growth factor signaling for therapeutic neovascularization, Adv Drug Delivery Rev, 59, 1340, 10.1016/j.addr.2007.08.012 · DOI
  111. Gu, 2004, Sustained delivery of vascular endothelial growth factor with alginate beads, J Control Release, 96, 463, 10.1016/j.jconrel.2004.02.021 · DOI · Paper page
  112. Jay, 2009, Controlled delivery of VEGF via modulation of alginate microparticle ionic cross-linking, J Control Release, 134, 26, 10.1016/j.jconrel.2008.10.019 · DOI
  113. Sun, 2010, Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis, Pharm Res, 27, 264, 10.1007/s11095-009-0014-0 · DOI
  114. Hao, 2007, Angiogenic effects of sequential release of VEGFA(165) and PDGF-BB with alginate hydrogels after myocardial infarction, Cardiovasc Res, 75, 178, 10.1016/j.cardiores.2007.03.028 · DOI · Paper page
  115. Ruvinov, 2011, The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction, Biomaterials, 32, 565, 10.1016/j.biomaterials.2010.08.097 · DOI · Paper page
  116. Lee, 2010, Active blood vessel formation in the ischemic hindlimb mouse model using a microsphere/hydrogel combination system, Pharm Res, 27, 767, 10.1007/s11095-010-0067-0 · DOI
  117. Peters, 2002, Engineering vascular networks in porous polymer matrices, J Biomed Mater Res, 60, 668, 10.1002/jbm.10134 · DOI · Paper page
  118. Silva, 2008, Material-based deployment enhances efficacy of endothelial progenitor cells, Proc Natl Acad Sci USA, 105, 14347, 10.1073/pnas.0803873105 · DOI · Paper page
  119. Kolambkar, 2011, An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects, Biomaterials, 32, 65, 10.1016/j.biomaterials.2010.08.074 · DOI · Paper page
  120. Lopiz-Morales, 2010, In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration, Eur Cells Mater, 20, 367, 10.22203/eCM.v020a30 · doi:10.22203/ecm.v020a30
  121. Krebs, 2010, Calcium alginate phosphate-DNA nanoparticle gene delivery from hydrogels induces in vivo osteogenesis, J Biomed Mater Res Part A, 92, 1131, 10.1002/jbm.a.32441 · DOI
  122. Basmanav, 2008, Sequential growth factor delivery from complexed microspheres for bone tissue engineering, Biomaterials, 29, 4195, 10.1016/j.biomaterials.2008.07.017 · DOI · Paper page
  123. Kanczler, 2010, The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation, Biomaterials, 31, 1242, 10.1016/j.biomaterials.2009.10.059 · DOI · Paper page
  124. Alsberg, 2002, Engineering growing tissues, Proc Natl Acad Sci USA, 99, 12025, 10.1073/pnas.192291499 · DOI · Paper page
  125. Lee, 2001, Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering, J Biomed Mater Res, 56, 228, 10.1002/1097-4636(200108)56:2<228::AID-JBM1089>3.0.CO;2-9 · DOI · Paper page
  126. Barralet, 2005, Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels, J Mater Sci Mater Med, 16, 515, 10.1007/s10856-005-0526-z · DOI
  127. Weng, 2006, Repair of experimental alveolar bone defects by tissue-engineered bone, Tissue Eng, 12, 1503, 10.1089/ten.2006.12.1503 · DOI
  128. Park, 2005, Injectable bone using chitosanalginate gel/mesenchymal stem cells/BMP-2 composites, J Cranio Maxill Surg, 33, 50, 10.1016/j.jcms.2004.05.011 · DOI
  129. Lin, 2004, Porous alginate/hydroxyapatite composite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies, J Biomed Mater Res Part B, 71, 52, 10.1002/jbm.b.30065 · DOI · Paper page
  130. Weir, 2006, Strong calcium phosphate cement–chitosan–mesh construct containing cell-encapsulating hydrogel beads for bone tissue engineering, J Biomed Mater Res Part A, 77, 487, 10.1002/jbm.a.30626 · doi:10.1002/jbm.a.30626
  131. Lawson, 2004, Adhesion and growth of bone marrow stromal cells on modified alginate hydrogels, Tissue Eng, 10, 1480, 10.1089/ten.2004.10.1480 · DOI
  132. Chang, 2001, Injection molding of chondrocyte/alginate constructs in the shape of facial implants, J Biomed Mater Res, 55, 503, 10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S · DOI · Paper page
  133. Chang, 2003, Tissue engineering of autologous cartilage for craniofacial reconstruction by injection molding, Plast Reconstr Surg, 112, 793, 10.1097/01.PRS.0000069711.31021.94 · DOI
  134. Thornton, 2004, Shape-defining scaffolds for minimally invasive tissue engineering, Transplantation, 77, 1798, 10.1097/01.TP.0000131152.71117.0E · DOI
  135. Ma, 2003, Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads, J Biomed Mater Res Part A, 64, 273, 10.1002/jbm.a.10370 · DOI
  136. Igarashi, 2010, A cellular implantation system using an injectable ultra-purified alginate gel for repair of osteochondral defects in a rabbit model, J Biomed Mater Res Part A, 94, 844, 10.1002/jbm.a.32762 · DOI
  137. Awad, 2004, Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds, Biomaterials, 25, 3211, 10.1016/j.biomaterials.2003.10.045 · DOI · Paper page
  138. Jin, 2007, Ectopic neocartilage formation from predifferentiated human adipose derived stem cells induced by adenoviral-mediated transfer of hTGF-beta2, Biomaterials, 28, 2994, 10.1016/j.biomaterials.2007.03.002 · DOI
  139. Park, 2009, Shear-reversibly cross-linked alginate hydrogels for tissue engineering, Macromol Biosci, 9, 895, 10.1002/mabi.200800376 · DOI
  140. Saxena, 1999, Skeletal muscle tissue engineering using isolated myoblasts on synthetic biodegradable polymers: preliminary studies, Tissue Eng, 5, 525, 10.1089/ten.1999.5.525 · DOI
  141. Levenberg, 2005, Engineering vascularized skeletal muscle tissue, Nat Biotechnol, 23, 879, 10.1038/nbt1109 · DOI · Paper page
  142. Borselli, 2010, Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors, Proc Natl Acad Sci USA, 107, 3287, 10.1073/pnas.0903875106 · DOI · Paper page
  143. Hill, 2006, Designing scaffolds to enhance transplanted myoblast survival and migration, Tissue Eng, 12, 1295, 10.1089/ten.2006.12.1295 · DOI
  144. Hill, 2006, Regulating activation of transplanted cells controls tissue regeneration, Proc Natl Acad Sci USA, 103, 2494, 10.1073/pnas.0506004103 · DOI · Paper page
  145. Prang, 2006, The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels, Biomaterials, 27, 3560
  146. Hashimoto, 2005, Peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds, J Mater Sci- Mater Med, 16, 503, 10.1007/s10856-005-0524-1 · DOI
  147. Kataoka, 2004, Alginate enhances elongation of early regenerating axons in spinal cord of young rats, Tissue Eng, 10, 493, 10.1089/107632704323061852 · DOI
  148. Suzuki, 2000, Reconstruction of rat peripheral nerve gap without sutures using freeze-dried alginate gel, J Biomed Mater Res, 49, 528, 10.1002/(SICI)1097-4636(20000315)49:4<528::AID-JBM11>3.0.CO;2-1 · doi:10.1002/(sici)1097-4636(20000315)49:4<528::aid-jbm11>3.0.co;2-1
  149. Li, 2006, Culture of neural stem cells in calcium alginate beads, Biotechnol Prog, 22, 1683, 10.1002/bp060185z · DOI
  150. Selden, 2004, Cellular therapies for liver replacement, Transpl Immunol, 12, 273, 10.1016/j.trim.2003.12.008 · DOI
  151. Koizumi, 2007, Long-term maintenance of the drug transport activity in cryopreservation of microencapsulated rat hepatocytes, Cell Transplantation, 16, 67, 10.3727/000000007783464489 · DOI
  152. Zmora, 2002, Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication, Biomaterials, 23, 4087, 10.1016/S0142-9612(02)00146-1 · DOI · Paper page
  153. Dvir-Ginzberg, 2003, Liver tissue engineering within alginate scaffolds: effects of cell-seeding density on hepatocyte viability, morphology, and function, Tissue Eng, 9, 757, 10.1089/107632703768247430 · DOI · Paper page
  154. Glicklis, 2000, Hepatocyte behavior within threedimensional porous alginate scaffolds, Biotechnol Bioeng, 67, 344, 10.1002/(SICI)1097-0290(20000205)67:3<344::AID-BIT11>3.0.CO;2-2 · DOI · Paper page
  155. Kedem, 2005, Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes, Tissue Eng, 11, 715, 10.1089/ten.2005.11.715 · DOI
  156. Lim, 1980, Microencapsulated islets as bioartificial endocrine pancreas, Science, 210, 908, 10.1126/science.6776628 · DOI · Paper page
  157. Lacy, 1991, Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets, Science, 254, 1782, 10.1126/science.1763328 · DOI · Paper page
  158. Calafiore, 2003, Alginate microcapsules for pancreatic islet cell graft immunoprotection: struggle and progress towards the final cure for type 1 diabetes mellitus, Exp Opin Biol Ther, 3, 201, 10.1517/14712598.3.2.201 · DOI
  159. Sakai, 2002, In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas, Biomaterials, 23, 4177, 10.1016/S0142-9612(02)00159-X · DOI
  160. Kendall, 2004, Effect of alginate composition and purity on alginate microspheres, J Microencapsulation, 21, 821, 10.1080/02652040400015452 · DOI
  161. Liu, 2006, Shape-controlled production of biodegradable calcium alginate gel microparticles using a novel microfluidic device, Langmuir, 22, 9453, 10.1021/la061729+ · DOI · Paper page
  162. Soon-Shiong, 1994, Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation, Lancet, 343, 950, 10.1016/S0140-6736(94)90067-1 · DOI · Paper page
  163. Diamond, 1998, Endoscopic treatment of vesicoureteric reflux in children using autologous chondrocytes – preliminary results, Pediatrics, 102, 107A
  164. Kershen, 2000, Tissue-engineered therapies for the treatment of urinary incontinence and vesicoureteral reflux, World J Urol, 18, 51, 10.1007/PL00007072 · DOI
  165. Kong, 2009, Design of biodegradable hydrogel for the local and sustained delivery of angiogenic plasmid DNA, Pharm Res, 25, 1230, 10.1007/s11095-007-9526-7 · doi:10.1007/s11095-007-9526-7
  166. Lee, 2000, Controlled growth factor release from synthetic extracellular matrices, Nature, 408, 998, 10.1038/35044106 · DOI · Paper page
  167. Zhao, 2011, Active scaffolds for on-demand drug and cell delivery, Proc Natl Acad Sci USA, 108, 67, 10.1073/pnas.1007862108 · DOI · Paper page
  168. Petka, 1998, Reversible hydrogels from selfassembling artificial proteins, Science, 281, 389, 10.1126/science.281.5375.389 · DOI · Paper page
  169. MacKay, 2009, Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nat Mater, 8, 993, 10.1038/nmat2569 · DOI · Paper page
  170. Sculean, 2001, Effect of an enamel matrix protein (Emdogain®) on ex vivo dental plaque vitality, J Clin Periodontol, 28, 1074, 10.1034/j.1600-051X.2001.281113.x · DOI
  171. Ali, 2008, Sustained GM-CSF and PEI condensed pDNA presentation increases the level and duration of gene expression in dendritic cells, J Control Release, 132, 273, 10.1016/j.jconrel.2008.07.005 · DOI
  172. Hashimoto, 2002, Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons, Exp Brain Res, 146, 356, 10.1007/s00221-002-1173-y · DOI
  173. Vacharathit, 2011, Viability and functionality of cells delivered from peptide conjugated scaffolds, Biomaterials, 32, 3721, 10.1016/j.biomaterials.2010.12.048 · DOI
  174. Guilak, 2009, Control of stem cell fate by physical interactions with the extracellular matrix, Cell Stem Cell, 5, 17, 10.1016/j.stem.2009.06.016 · DOI · Paper page
  175. Dashtdar, 2011, A preliminary study comparing the use of allogenic chondrogenic pre-differentiated and undifferentiated mesenchymal stem cells for the repair of full thickness articular cartilage defects in rabbits, J Orthop Res, 29, 1336, 10.1002/jor.21413 · DOI
  176. Tuan, 2003, Adult mesenchymal stem cells and cell-based tissue engineering, Arthritis Res Ther, 51, 32, 10.1186/ar614 · DOI

Cited by

See all 8,095

Metadata

Authors
Lee, K. Y., & Mooney, D. J.
Venue
Progress in Polymer Science
Publisher
Elsevier BV
Published
2012-01
Volume
37
Issue
1
Pages
106-126
ISSN
0079-6700 (ISSN-L)
OpenAlex
W1971500643
Cited by
8,095
References
5
FWCI
41.81
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Alginate: Properties and biomedical applications. https://app.cochat.ai/papers/10.1016/j.progpolymsci.2011.06.003
The paper
Lee, K. Y., & Mooney, D. J. (2012). Alginate: Properties and biomedical applications. Progress in Polymer Science. https://doi.org/10.1016/j.progpolymsci.2011.06.003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.