Chitosan-based blends for biomedical applications
Abstract
Polysaccharides are the most abundant naturally available carbohydrate polymers; composed of monosaccharide units covalently connected together. Chitosan is the most widely used polysaccharides because of its exceptional biocompatibility, mucoadhesion, and chemical versatility. However, it suffers from a few drawbacks, e.g. poor mechanical properties and antibacterial activity for biomedical applications. Blending chitosan with natural or synthetic polymers may not merely improve its physicochemical and mechanical properties, but may also improve its bioactivity-induced properties. This review paper summarizes progress in chitosan blends with biodegradable polymers and polysaccharides and their biomedical applications. Blends of chitosan with alginate, starch, cellulose, pectin and dextran and their applications were particularly addressed. The critical and challenging aspects as well as the future ahead of the use of chitosan-based blends were eventually enlightened.
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Incorporating collagen, chitosan, gelatin, or hyaluronic acid into alginate hydrogels significantly improves their anti-adhesion performance.
“Several studies have demonstrated that incorporating collagen, chitosan, gelatin, or hyaluronic acid into alginate hydrogels significantly improves their anti-adhesion performance [177].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [177]
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Drug release study of the chitosan-based nanoparticles
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Seidi, F., Khodadadi Yazdi, M., Jouyandeh, M., Dominic, M., Naeim, H., Nezhad, M. N., Bagheri, B., Habibzadeh, S., Zarrintaj, P., Saeb, M. R., & Mozafari, M.
- Affiliations
- Nanjing Forestry University (CN)
- University of Tehran (IR)
- Urmia University of Technology (IR)
- Korea Advanced Institute of Science and Technology (KR)
- Amirkabir University of Technology (IR)
- Oklahoma State University (US)
- Iran University of Medical Sciences (IR)
- Corresponding author
- Saeb, Mohammad Reza
- Mozafari, Masoud
- ORCID
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 183
- Pages
- 1818-1850
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3158086260
- Cited by
- 199
- References
- 3
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 50 · 2023: 54 · 2022: 29 · 2021: 10
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- chitosan, polymer blends, polysaccharide blends, biodegradable polymers, alginate, starch, cellulose, pectin, dextran, mechanical properties, mucoadhesion, biocompatibility, biomedical applications
- MeSH terms
- Alginates, Polysaccharides, Tissue Engineering, Chitosan
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