Cited by 576Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems

Drug release study of the chitosan-based nanoparticles

Open access
Herdiana, Yedi, Wathoni, Nasrul, Shamsuddin, Shaharum, Muchtaridi, Muchtaridi·2022·Heliyon

Abstract

Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.

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Crossref · 10.1016/j.heliyon.2021.e08674

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  • After modification or stimulation by corresponding factors, smart nanoparticles efficiently aggregate at the target location and release their payloads.

    “After modification or stimulation by corresponding factors, these smart nanoparticles efficiently aggregate at the target location and release their payloads, establishing a smart treatment mode.8–12”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [11]

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  1. [12]D’Souza S. A review of in vitro drug release test methods for nano-sized dosage forms Adv. Pharm. 2014 2014 1 12
  2. [141]Rawal S.U. Patel M.M. Lipid Nanoparticulate Systems: Modern Versatile Drug Carriers 2018 Elsevier

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Authors
Herdiana, Y., Wathoni, N., Shamsuddin, S., & Muchtaridi, M.
Affiliations
  • Padjadjaran University (ID)
  • Universiti Sains Malaysia (MY)
Corresponding author
Muchtaridi, Muchtaridi
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-01
Volume
8
Issue
1
Pages
e08674
ISSN
2405-8440 (ISSN-L)
OpenAlex
W4200550789
Cited by
576
References
144
Citations by year
2026: 135 · 2025: 176 · 2024: 140 · 2023: 85 · 2022: 40
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • Heliyon (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministry of Education Culture Research and Technology (1207/UN6.3.1/PT.00/2021)
  • Universitas Padjadjaran
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
chitosan nanoparticles, drug release, controlled drug release, release kinetics, kinetic model, multifunctional drug delivery systems, polymer modification, burst release, stimuli-responsive release, targeted drug delivery, drug solubility enhancement

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