Drug release study of the chitosan-based nanoparticles
Open accessAbstract
Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.
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After modification or stimulation by corresponding factors, smart nanoparticles efficiently aggregate at the target location and release their payloads.
“After modification or stimulation by corresponding factors, these smart nanoparticles efficiently aggregate at the target location and release their payloads, establishing a smart treatment mode.8–12”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [11]
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George, D., Maheswari, P. U., & Begum, K. M. M. S. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116101 · Cited by 156 · see citing works
RetractedLoutfy, S. A., Elberry, M. H., Farroh, K. Y., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s241702 · Cited by 109 · see citing works
RetractedEngineering precision nanoparticles for drug delivery
Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933 · see citing works
Nano based drug delivery systems: recent developments and future prospects
Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodríguez-Torres, M. D. P., Acosta‐Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 6,720 · see citing works
Biodegradable polymeric nanoparticles based drug delivery systems
Kumari, A., Yadav, S. K., & Yadav, S. C. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.09.001 · Cited by 3,755 · see citing works
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
Nanoparticle-based targeted drug delivery
Singh, R., & Lillard, J. W. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.12.004 · Cited by 2,745 · see citing works
Recent advances on chitosan-based micro- and nanoparticles in drug delivery
Agnihotri, S. A., Nadagouda, M. N., & Aminabhavi, T. M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.010 · Cited by 2,589 · see citing works
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Zielińska, A., Carreiró, F., Oliveira, A. M., Neves, A., Pires, B., Venkatesh, D. N., Durazzo, A., Lucarini, M., Eder, P., Silva, A. M., et al. (2020) · Molecules · doi:10.3390/molecules25163731 · Cited by 1,625 · see citing works
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,597 · see citing works
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
Mohammed, M., Syeda, J., Wasan, K. M., & Wasan, E. K. (2017) · Pharmaceutics · doi:10.3390/pharmaceutics9040053 · Cited by 1,366 · see citing works
Applications of nanoparticle systems in drug delivery technology
Rizvi, S. A. A., & Saleh, A. (2017) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2017.10.012 · Cited by 1,340 · see citing works
Why degradable polymers undergo surface erosion or bulk erosion
Burkersroda, F. V., Schedl, L., & Göpferich, A. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00170-9 · Cited by 1,146 · see citing works
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Yetisgin, A. A., Çetinel, S., Zuvin, M., Koşar, A., & Kutlu, Ö. (2020) · Molecules · doi:10.3390/molecules25092193 · Cited by 1,103 · see citing works
Vakili, M., Rafatullah, M., Salamatinia, B., Abdullah, A. Z., Ibrahim, M. H., Tan, K. B., Gholami, Z., & Amouzgar, P. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.07.007 · Cited by 1,099 · see citing works
Current development of biodegradable polymeric materials for biomedical applications
Song, R., Murphy, M. C., Li, C., Ting, K., Soo, C. B., & Zheng, Z. S. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s165440 · Cited by 931 · see citing works
Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844 · see citing works
Chitosan: A review of sources and preparation methods
Kou, S., Peters, L. M., & Mucalo, M. R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.005 · Cited by 844 · see citing works
Controlled drug release from pharmaceutical nanocarriers
Lee, J. H., & Yeo, Y. (2014) · Chemical Engineering Science · doi:10.1016/j.ces.2014.08.046 · Cited by 642 · see citing works
Safe Nanoparticles: Are We There Yet?
Najahi‐Missaoui, W., Arnold, R. D., & Cummings, B. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010385 · Cited by 600 · see citing works
Chitosan-Based Particles as Controlled Drug Delivery Systems
Prabaharan, M., & Mano, J. F. (2004) · Drug Delivery · doi:10.1080/10717540590889781 · Cited by 564 · see citing works
Khalil, H. P. S. A., Saurabh, C. K., Adnan, A. S., Rawi, N. F. M., Syakir, M., Davoudpour, Y., Rafatullah, M., Abdullah, C. K., Kassim, M. H. M., & Dungani, R. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.05.028 · Cited by 547 · see citing works
Physiological Parameters for Oral Delivery and in Vitro Testing
Mudie, D. M., Amidon, G. L., & Amidon, G. E. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100149j · Cited by 496 · see citing works
Chitosan hydrogels for sustained drug delivery
Peers, S., Montembault, A., & Ladavière, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.012 · Cited by 451 · see citing works
Chitosan-based nanoparticles against bacterial infections
Rashki, S., Asgarpour, K., Tarrahimofrad, H., Hashemipour, M., Ebrahimi, M. S., Fathizadeh, H., Khorshidi, A., Khan, H. Z., Marzhoseyni, Z., Salavati‐Niasari, M., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117108 · Cited by 435 · see citing works
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430 · see citing works
A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications
Idrees, H., Zaidi, S. Z. J., Sabir, A., Khan, R. U., Zhang, X., & Hassan, S.-U. (2020) · Nanomaterials · doi:10.3390/nano10101970 · Cited by 421 · see citing works
Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
Edis, Z., Wang, J., Waqas, M. K., Ijaz, M., & Ijaz, M. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s289443 · Cited by 401 · see citing works
Zero-order drug delivery: State of the art and future prospects
Laracuente, M., Yu, M. H., & McHugh, K. J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.020 · Cited by 392 · see citing works
Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery
Zahin, N., Anwar, R., Tewari, D., Kabir, M. T., Sajid, A., Mathew, B., Uddin, M. S., Aleya, L., & Abdel‐Daim, M. M. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05211-0 · Cited by 383 · see citing works
Masarudin, M. J., Cutts, S. M., Evison, B. J., Phillips, D. R., & Pigram, P. J. (2015) · Nanotechnology Science and Applications · doi:10.2147/nsa.s91785 · Cited by 347 · see citing works
Parameters influencing the size of chitosan-TPP nano- and microparticles
Sreekumar, S., Goycoolea, F. M., Moerschbacher, B. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23064-4 · Cited by 330 · see citing works
Jahromi, L. P., Ghazali, M., Ashrafi, H., & Azadi, A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03451 · Cited by 330 · see citing works
Chitosan Based Self-Assembled Nanoparticles in Drug Delivery
Quiñones, J. P., Peniche, H., & Peniche-Covas, C. (2018) · Polymers · doi:10.3390/polym10030235 · Cited by 326 · see citing works
In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery
Jain, A. K., & Thareja, S. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1561457 · Cited by 322 · see citing works
Son, G.-H., Lee, B., & Cho, C. (2017) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-017-0320-1 · Cited by 321 · see citing works
Pantani, R., & Sorrentino, A. (2013) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2013.01.005 · Cited by 317 · see citing works
Modi, S., & Anderson, B. D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400154a · Cited by 314 · see citing works
Systemic Review of Biodegradable Nanomaterials in Nanomedicine
Su, S., & Kang, P. M. (2020) · Nanomaterials · doi:10.3390/nano10040656 · Cited by 314 · see citing works
Weng, J., Tong, H. H. Y., & Chow, S. F. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080732 · Cited by 304 · see citing works
Studies on glass transition temperature of chitosan with four techniques
Dong, Y., Ruan, Y., Wang, H., et al. (2004) · Journal of Applied Polymer Science · doi:10.1002/app.20630 · Cited by 298 · see citing works
Shu, X. Z., & Zhu, K. J. (2002) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00052-8 · Cited by 291 · see citing works
Degradability of chitosan micro/nanoparticles for pulmonary drug delivery
Islam, N., Dmour, I. M., & Taha, M. O. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01684 · Cited by 275 · see citing works
Modeling of drug release from bulk-degrading polymers
Lao, L. L., Peppas, N. A., Boey, F. Y. C., & Venkatraman, S. S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.020 · Cited by 251 · see citing works
Varma, M. V. S., Kaushal, A. M., Garg, A. B., et al. (2004) · American Journal of Drug Delivery · doi:10.2165/00137696-200402010-00003 · Cited by 244 · see citing works
Nanotoxicology of Metal Oxide Nanoparticles
Seabra, A. B., & Durán, N. (2015) · Metals · doi:10.3390/met5020934 · Cited by 237 · see citing works
Influence of chitosan characteristics on polymer properties. I: Crystallographic properties
Jaworska, M. M., Sakurai, K., Gaudon, P., & Guibal, E. (2003) · Polymer International · doi:10.1002/pi.1159 · Cited by 229 · see citing works
Emerging Concepts in Analysis and Applications of Hydrogels
Majee, S. B. (2016) · InTech eBooks · doi:10.5772/61692 · Cited by 211 · see citing works
Shoueir, K. R., El-Desouky, N., Rashad, M. M., Ahmed, M., Janowska, I., & El-Kemary, M. A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.072 · Cited by 200 · see citing works
Chitosan-based blends for biomedical applications
Seidi, F., Khodadadi Yazdi, M., Jouyandeh, M., Dominic, M., Naeim, H., Nezhad, M. N., Bagheri, B., Habibzadeh, S., Zarrintaj, P., Saeb, M. R., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.003 · Cited by 199 · see citing works
Weiss, M., Fan, J., Claudel, M., Sonntag, T., Didier, P., Ronzani, C., Lebeau, L., & Pons, F. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00747-7 · Cited by 190 · see citing works
Biodegradable polymers in drug delivery and oral vaccination
Jana, P., Shyam, M., Singh, S., Jayaprakash, V., & Dev, A. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110155 · Cited by 180 · see citing works
Karthika, V., AlSalhi, M. S., Devanesan, S., Gopinath, K., Arumugam, A., & Govindarajan, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-76015-3 · Cited by 174 · see citing works
Hoàng, T., Chinh, N. T., Thach, L. T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57666-8 · Cited by 172 · see citing works
Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
Han, Y., Gao, Z., Chen, L., Kang, L., Huang, W., Jin, M., Wang, Q., & Bae, Y. H. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.004 · Cited by 165 · see citing works
Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review
Awad, N. S., Paul, V., AlSawaftah, N., ter Haar, G., Allen, T. M., Pitt, W. G., & Husseini, G. A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00212 · Cited by 163 · see citing works
The biodegradation of amorphous and crystalline regions in film-blown poly(ε-caprolactone)
Eldsäter, C. (2000) · Polymer · doi:10.1016/s0032-3861(99)00278-5 · Cited by 162 · see citing works
Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections
Sánchez, A., Mejía, S. P., & Orozco, J. (2020) · Molecules · doi:10.3390/molecules25163760 · Cited by 161 · see citing works
Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
Iacob, A.-T., Lupaşcu, F., Apotrosoaei, M., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040587 · Cited by 156 · see citing works
Advances in chitosan-based nanoparticles for oncotherapy
Zhang, E.-H., Xing, R., Liu, S., Qin, Y., Li, K., & Li, P. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115004 · Cited by 152 · see citing works
Potential of Chitosan and its derivatives for controlled drug release applications – A review
Safdar, R., Omar, A. A., Arunagiri, A., et al. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.10.020 · Cited by 148 · see citing works
Chitosan-based drug delivery systems: From synthesis strategy to osteomyelitis treatment – A review
Tao, F., Ma, S., Tao, H., Jin, L., Luo, Y. Y., Zheng, J., Xiang, W., & Deng, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117063 · Cited by 147 · see citing works
Vaghani, S. S., Patel, M. M., & Satish, C. S. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.04.048 · Cited by 143 · see citing works
Advances in nanomedical applications: diagnostic, therapeutic, immunization, and vaccine production
El-Sayed, A., & Kamel, M. S. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06459-2 · Cited by 141 · see citing works
Hu, X., Wang, Y., Zhang, L., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115920 · Cited by 140 · see citing works
Tumor‐Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity
Ryu, J. H., Yoon, H. Y., Sun, I., Kwon, I. C., & Kim, K. (2020) · Advanced Materials · doi:10.1002/adma.202002197 · Cited by 138 · see citing works
Is dialysis a reliable method for studying drug release from nanoparticulate systems?—A case study
Zambito, Y., Pedreschi, E., & Di Colo, G. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.05.020 · Cited by 136 · see citing works
Hassani, S., Laouini, A., Fessi, H., et al. (2015) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2015.04.006 · Cited by 133 · see citing works
Peltonen, L. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.009 · Cited by 132 · see citing works
Chitosan microspheres in novel drug delivery systems.
Mitra, A., & Dey, B. (2011) · PubMed · doi:10.4103/0250-474x.95607 · Cited by 127 · see citing works
Development of Chitosan Nanoparticles as a Stable Drug Delivery System for Protein/siRNA
Katas, H., Raja, M. A. G., & Lam, K. L. (2013) · International Journal of Biomaterials · doi:10.1155/2013/146320 · Cited by 126 · see citing works
El-Alfy, E. A., El-Bisi, M. K., Taha, G. M., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.118 · Cited by 117 · see citing works
Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine
Damasco, J. A., Ravi, S., Perez, J. V. D., Hagaman, D., & Melancon, M. P. (2020) · Nanomaterials · doi:10.3390/nano10112186 · Cited by 116 · see citing works
Samy, M., El-Alim, S. H. A., Rabia, A. E. G., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.112 · Cited by 113 · see citing works
Polymer Science and Nanotechnology
(2020) · Elsevier eBooks · doi:10.1016/c2018-0-01134-2 · Cited by 110 · see citing works
Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers
Caprifico, A. E., Foot, P. J. S., Polycarpou, E., & Calabrese, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111013 · Cited by 108 · see citing works
Kunjachan, S., & Jose, S. (2010) · Asian Journal of Pharmaceutics · doi:10.4103/0973-8398.68467 · Cited by 106 · see citing works
Chitosan-Alginate Nanoparticle System Efficiently Delivers Doxorubicin to MCF-7 Cells
Katuwavila, N. P., Perera, A. D. L. C., Samarakoon, S. R., et al. (2016) · Journal of Nanomaterials · doi:10.1155/2016/3178904 · Cited by 99 · see citing works
Al‐Nemrawi, N. K., Alsharif, S. S. M., & Dave, R. H. (2018) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2018v10i5.26375 · Cited by 97 · see citing works
Sorasitthiyanukarn, F. N., Muangnoi, C., Rojsitthisak, P., & Rojsitthisak, P. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117426 · Cited by 95 · see citing works
PEGylation of chitosan for improved solubility and fiber formation via electrospinning
Du, J., & Hsieh, Y. (2007) · Cellulose · doi:10.1007/s10570-007-9122-3 · Cited by 91 · see citing works
Effect of crosslink density on the creep behavior of natural rubber vulcanizates
Plazek, D. J. (1966) · Journal of Polymer Science Part A-2 Polymer Physics · doi:10.1002/pol.1966.160040507 · Cited by 89 · see citing works
Huang, X., Wu, S., & Du, X. (2016) · Carbon · doi:10.1016/j.carbon.2016.01.094 · Cited by 87 · see citing works
Choudhary, P., Ramalingam, B., & Das, S. K. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00923 · Cited by 83 · see citing works
Saravanakumar, K., Mariadoss, A. V. A., Sathiyaseelan, A., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.177 · Cited by 82 · see citing works
Chen, T., Li, S., Zhu, W., et al. (2019) · Journal of Microencapsulation · doi:10.1080/02652048.2019.1604846 · Cited by 77 · see citing works
Abdo, G. G., Zagho, M. M., & Khalil, A. A. (2020) · Emergent Materials · doi:10.1007/s42247-020-00109-x · Cited by 76 · see citing works
The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation
Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1400552 · Cited by 73 · see citing works
Mathematical modeling of drug release from swellable polymeric nanoparticles
Azadi, S., Ashrafi, H., & Azadi, A. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.70418 · Cited by 68 · see citing works
Chitosan as a machine for biomolecule delivery: A review.
Mohammadi, Z., Eini, M., Rastegari, A., & Tehrani, M. R. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117414 · Cited by 67 · see citing works
Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone
Katas, H., Hussain, Z., & Ling, T. C. (2012) · Journal of Nanomaterials · doi:10.1155/2012/372725 · Cited by 65 · see citing works
Muhsin, M. D. A., George, G. A., Beagley, K. W., et al. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00859 · Cited by 65 · see citing works
Dual-responsive nanoparticles based on chitosan for enhanced breast cancer therapy
Zhang, X., Niu, S., Williams, G. R., et al. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.081 · Cited by 63 · see citing works
Drug release testing methods of polymeric particulate drug formulations
Amatya, S., Park, E. J., Park, J. H., Kim, J. S., Seol, E., Lee, H., Choi, H., Shin, Y.-H., & Na, D. H. (2013) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-013-0072-5 · Cited by 61 · see citing works
Application of Glass Transition in Food Processing
Balasubramanian, S., Devi, A., Singh, K. K., Bosco, S. J. D., & Mohite, A. M. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.734343 · Cited by 60 · see citing works
Chitosan‐based self‐assembled nanomaterials: Their application in drug delivery
Liu, Y., Sun, M., Wang, T., Chen, X., & Wang, H. (2020) · Open Research (University of Surrey) · doi:10.1002/viw.20200069 · Cited by 58 · see citing works
Li, J., Ma, F. K., Dang, Q., Liang, X., & Chen, X. (2014) · Frontiers of Materials Science · doi:10.1007/s11706-014-0262-8 · Cited by 57 · see citing works
Khanmohammadi, M., Elmizadeh, H., & Ghasemi, K. (2015) · PubMed · Cited by 56 · see citing works
Chitosan-based hydrogel nanoparticle amazing behaviors during transmission electron microscopy
Ashrafi, H., & Azadi, A. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.089 · Cited by 54 · see citing works
Loutfy, S. A., Elberry, M. H., Farroh, K. Y., et al. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 54 · see citing works
Stimuli-responsive poly(ionic liquid) nanoparticles for controlled drug delivery
Lü, B., Zhou, G., Xiao, F., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01352h · Cited by 53 · see citing works
Liu, Q., Li, Y., Yang, X., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116112 · Cited by 51 · see citing works
Arnold, A. E., Czupiel, P., & Shoichet, M. S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.019 · Cited by 46 · see citing works
Biochemical Toxicology: Heavy Metals and Nanomaterials
Raj, S., & Kumar, D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90928 · Cited by 46 · see citing works
Click cross-linking improves retention and targeting of refillable alginate depots
Moody, C. T., Palvai, S., & Brudno, Y. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.033 · Cited by 45 · see citing works
Photo-responsive degradable hollow mesoporous organosilica nanoplatforms for drug delivery
Fan, J. Q., Zhang, Z., Wang, Y., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00642-1 · Cited by 45 · see citing works
Bikiaris, D. Ν., Papageorgiou, G. Z., Papadimitriou, S. A., Karavas, E., & Avgoustakis, K. (2009) · AAPS PharmSciTech · doi:10.1208/s12249-008-9184-z · Cited by 43 · see citing works
Isoda, K., Tanaka, A., Fuzimori, C., et al. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03371-4 · Cited by 42 · see citing works
Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers
Szafraniec-Szczęsny, J., Janik-Hazuka, M., Odrobińska, J., & Zapotoczny, S. (2020) · Polymers · doi:10.3390/polym12091999 · Cited by 41 · see citing works
Polymers in Drug Delivery: An Update
Bhatt, P., Trehan, S., Inamdar, N., Mourya, V. K., & Misra, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819659-5.00001-x · Cited by 40 · see citing works
Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy
Yhee, J. Y., Koo, H., Lee, D., et al. (2011) · Advances in polymer science · doi:10.1007/12_2011_119 · Cited by 36 · see citing works
Joy, N., & Samavedi, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c00954 · Cited by 35 · see citing works
Chitosan-based nanocomposites: preparation and characterization for food packing industry
Ahmed, E. M., Saber, D., El‐Aziz, K. A., Alghtani, A. H., Felemban, B. F., Ali, H. T., & Megahed, M. (2021) · Materials Research Express · doi:10.1088/2053-1591/abe791 · Cited by 35 · see citing works
Chen, Z., Han, S., Yang, X., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s251627 · Cited by 33 · see citing works
Quiñones, J., Szopko, R., Schmidt, C., & Covas, C. P. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.12.007 · Cited by 32 · see citing works
Water Soluble Chitosan Derivatives and their Biological Activities: A Review
Kahya, N. (2019) · doi:10.36648/2471-9935.5.1.44 · Cited by 32 · see citing works
Nogueira-Librelotto, D. R., Scheeren, L. E., Macedo, L. B., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110897 · Cited by 32 · see citing works
Porous chitosan by crosslinking with tricarboxylic acid and tuneable release
Yang, Y., Chen, G.-H., Murray, P. A., & Zhang, H. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-2252-z · Cited by 31 · see citing works
Yemişçi, M., Caban-Toktas, S., Fernández-Megía, E., Çapan, Y., Couvreur, P., & Dalkara, T. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7571-6_36 · Cited by 30 · see citing works
Unsteady two-film model for mass transfer accompanied by chemical reaction
Wang, J., & Langemann, H. (1994) · Chemical Engineering Science · doi:10.1016/0009-2509(94)00160-x · Cited by 30 · see citing works
Polymers used in the Designing of Controlled Drug Delivery System
Sowjanya, M., Debnath, S., Lavanya, P., et al. (2017) · Research Journal of Pharmacy and Technology · doi:10.5958/0974-360x.2017.00168.8 · Cited by 29 · see citing works
Sharma, S. K., Sudarshan, K., Sahu, M., et al. (2016) · RSC Advances · doi:10.1039/c6ra07051e · Cited by 28 · see citing works
Application of different nanoparticles in the diagnosis of colorectal cancer
Ghorbani, F., Kokhaei, P., Ghorbani, M., & Eslami, M. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100896 · Cited by 28 · see citing works
Determining drug release rates of hydrophobic compounds from nanocarriers
D’Addio, S. M., Bukari, A. A., Dawoud, M., Bunjes, H., Rinaldi, C., & Prud’homme, R. K. (2016) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2015.0128 · Cited by 27 · see citing works
Mulikova, T., Abduraimova, A., Molkenova, A., et al. (2021) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2021.100712 · Cited by 27 · see citing works
Petersen, R. S., Nielsen, L. H., Rindzevicius, T., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111050 · Cited by 26 · see citing works
Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications
Hassan, N., Oyarzun-Ampuero, F. A., Lara, P., et al. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666140118213915 · Cited by 23 · see citing works
Controlled drug release from polyelectrolyte–drug conjugate nanoparticles
Catarata, R., Azim, N., Bhattacharya, S., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00012d · Cited by 22 · see citing works
Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone
Büyük, N. İ., Arayıcı, P. P., Derman, S., et al. (2020) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.630 · Cited by 22 · see citing works
The Improvement of Hydrophilic Property of Polyethersulfone Membrane with Chitosan as Additive
Fathanah, U., Machdar, I., Riza, M., et al. (2020) · Jurnal Rekayasa Kimia & Lingkungan · doi:10.23955/rkl.v15i1.15916 · Cited by 21 · see citing works
Chitosan: Strategies to Increase and Modulate Drug Release Rate
Lucio, D., & Martínez-Ohárriz, M. C. (2017) · InTech eBooks · doi:10.5772/65714 · Cited by 20 · see citing works
Atorvastatin-loaded nanosprayed chitosan nanoparticles for peripheral nerve injury
Haidar, M. K., Demirbolat, G. M., Timur, S. S., et al. (2019) · Bioinspired Biomimetic and Nanobiomaterials · doi:10.1680/jbibn.19.00006 · Cited by 17 · see citing works
Kizaloglu, A., Kılıçay, E., Karahaliloğlu, Z., et al. (2020) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911520943222 · Cited by 15 · see citing works
Structural Insight into Chitosan Supports Functionalized with Nanoparticles
Lamarra, J., Damonte, L. C., Rivero, S., et al. (2018) · Advances in Materials Science and Engineering · doi:10.1155/2018/3965783 · Cited by 13 · see citing works
Modelling degradation of biodegradable polymers
Han, X., & Zhang, X. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100372-5.00015-5 · Cited by 12 · see citing works
Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver
Kulpreechanan, N., & Sorasitthiyanukarn, F. N. (2020) · International Journal of Research in Pharmaceutical Sciences · doi:10.26452/ijrps.v11i3.2685 · Cited by 12 · see citing works
Ghassemi, B., Nayeri, F. D., & Hosseini, R. (2021) · International Journal of Advanced Biological and Biomedical Research · doi:10.22034/ijabbr.2021.523524.1343 · Cited by 12 · see citing works
Glass Transition in Crosslinked Nanocomposite Scaffolds of Gelatin/Chitosan/Hydroxyapatite
Catalan, K. N., Corrales, T. P., Forero, J. C., et al. (2019) · Polymers · doi:10.3390/polym11040642 · Cited by 10 · see citing works
Functionalization and Grafting of Nanoparticle Surfaces
Zhu, G., Liu, Y., Sweeney, S. W., et al. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.13152-x · Cited by 9 · see citing works
Dathathri, E., Thakur, G., Koteshwara, K. B., et al. (2019) · Chemical Papers · doi:10.1007/s11696-019-01024-0 · Cited by 9 · see citing works
Gastrointestinal Delivery of APIs from Chitosan Nanoparticles
Sabra, R., & Billa, N. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.95363 · Cited by 9 · see citing works
Synthesis of Polymer-Drug Conjugates Using Natural Polymer: What, Why and How?
Sagita, E., Syahdi, R. R., & Arrahman, A. (2018) · Pharmaceutical Sciences and Research · doi:10.7454/psr.v5i3.4376 · Cited by 6 · see citing works
Computational Modeling of Drug Release Profiles from Swellable Polymeric Nanoparticles
Ahmed, L., Yahya, I., & Eltayeb, M. (2019) · International Conference on Computer, Control, Electrical, and Electronics Engineering (ICCCEEE) · doi:10.1109/iccceee46830.2019.9070894 · Cited by 5 · see citing works
Targeted drug delivery across biological barriers using polymer nanoparticles
Gagliardi, M., Bardi, G., Gamucci, O., & Mazzolai, B. (2013) · doi:10.4155/ebo.13.266 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [12]D’Souza S. A review of in vitro drug release test methods for nano-sized dosage forms Adv. Pharm. 2014 2014 1 12
- [141]Rawal S.U. Patel M.M. Lipid Nanoparticulate Systems: Modern Versatile Drug Carriers 2018 Elsevier
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Georgieva, D., Nikolova, D., Vassileva, E., & Kostova, B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030829 · Cited by 60 · see citing works
- Authors
- Herdiana, Y., Wathoni, N., Shamsuddin, S., & Muchtaridi, M.
- Affiliations
- Padjadjaran University (ID)
- Universiti Sains Malaysia (MY)
- Corresponding author
- Muchtaridi, Muchtaridi
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 8
- Issue
- 1
- Pages
- e08674
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC8741465
- OpenAlex
- W4200550789
- Cited by
- 576
- References
- 144
- Citations by year
- 2026: 135 · 2025: 176 · 2024: 140 · 2023: 85 · 2022: 40
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education Culture Research and Technology (1207/UN6.3.1/PT.00/2021)
- Universitas Padjadjaran
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- chitosan nanoparticles, drug release, controlled drug release, release kinetics, kinetic model, multifunctional drug delivery systems, polymer modification, burst release, stimuli-responsive release, targeted drug delivery, drug solubility enhancement
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