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Cited by 34Bone Tissue Engineering MaterialsBone Metabolism and DiseasesMedicinal Plant Pharmacodynamics Research

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells

Oh, Yunok, Ahn, Chang-Bum, Marasinghe, M.P.C.K., Je, Jae-Young·2021·International Journal of Biological Macromolecules
DOI 10.1016/j.ijbiomac.2021.05.122
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Abstract

Chitosan, a naturally occurring biodegradable and biocompatible polymer, has found use as a food additive, nutraceuticals, and functional foods in recent years. In this study, gallic acid-g-chitosan (GAC) was prepared by the insertion of GA onto plain chitosan (PC) via free radical-mediated grafting and its osteogenic effects were investigated in murine bone marrow-derived mesenchymal stem cells (mBMMSCs). Structural characterization of PC and GAC was performed using 1 H NMR and FT-IR spectroscopy. The amount of GA successfully grafted onto PC was 111 mg GA/g GAC via the Folin-Ciocalteu's method. While PC and GAC promoted the increase in alkaline phosphatase activity and mineralization, GAC increased these factors significantly more than PC, indicating that the grafting of GA onto chitosan increased its osteogenic potential. Mechanistic study revealed that GAC activated Wnt1 and Wnt3a mRNA and protein expression as well as increased the translocation of β-catenin into the nucleus and upregulated the expression of β-catenin targeted genes including Runx2, osterix, type I collagen and cyclin D1. In addition, DKK-1, a Wnt antagonist, decreased GAC-mediated osteoblast differentiation in mBMMSCs through blocking the Wnt/β-catenin signaling pathway.

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Crossref · 10.1016/j.ijbiomac.2021.05.122

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Metadata

Authors
Oh, Y., Ahn, C.-B., Marasinghe, M. P. C. K., & Je, J.-Y.
Affiliations
  • Kyungsung University (KR)
  • Chonnam National University (KR)
  • Pukyong National University (KR)
Corresponding author
Je, Jae-Young
ORCID
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2021-07
Volume
183
Pages
1410-1418
ISSN
0141-8130 (ISSN-L)
DOI
10.1016/j.ijbiomac.2021.05.122
OpenAlex
W3163900972
Cited by
34
References
55
Citations by year
2026: 5 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 1
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
Keywords
gallic acid, chitosan, grafting, osteogenic differentiation, mesenchymal stem cells, bone marrow-derived stem cells, Wnt/β-catenin signaling, DKK1, alkaline phosphatase activity, mineralization, Runx2, Osterix, type I collagen, cyclin D1
MeSH terms
Animals, Cell Differentiation, Gallic Acid, Magnetic Resonance Spectroscopy, Osteoblasts, Cyclin D1, Collagen Type I, Chitosan, beta Catenin, Mice, Mesenchymal Stem Cells

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CoChat. (2026). Citation check: Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells. https://app.cochat.ai/papers/10.1016/j.ijbiomac.2021.05.122
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Oh, Y., Ahn, C.-B., Marasinghe, M. P. C. K., & Je, J.-Y. (2021). Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2021.05.122