Cited by 81Polysaccharides Composition and ApplicationsFungal Biology and ApplicationsPolysaccharides and Plant Cell Walls

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

The variation on structure and immunomodulatory activity of polysaccharide during the longan pulp fermentation

Hu, Teng-Gen, Zhu, Wei-Lin, Yu, Yuan-Shan, Zou, Bo, Xu, Yu-Juan, Xiao, Geng-Sheng, Wu, Ji-Jun·2022·International Journal of Biological Macromolecules

Abstract

In the current study, the effects of fermentation manners on the structure and immunomodulatory activity of polysaccharide in longan wine or vinegar were investigated. Compared to longan polysaccharide (CP1), polysaccharide in longan wine (CP2) or vinegar (CP3 and CP4) had smaller molecular weights, and was consisted of more mannose, arabinose, rhamnose, galactose and less glucose. After purification, the major fraction (P1-P4) was obtained from CP1-CP4, respectively. The structures and immunoregulatory activities of P1-P4 were characterized. Fermentation and purification were favorable to increase the immunoregulatory activities of P2-P4, which were contributed to their different structural features. The structure-activity relationship analysis indicated that molecular weight, mannose, rhamnose, glucuronic acid, glucose and arabinose were significantly associated with the cytokines secretion. Compared with other polysaccharides, P3 displayed better immunomodulatory activity due to its lower molecular weight, lower contents of rhamnose and glucose, and higher levels of mannose and arabinose by activating MAPK and PI3K/Akt signaling pathways.

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Crossref · 10.1016/j.ijbiomac.2022.09.195

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Citations

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Research works printed but not linked: 2

  1. Zhu, 2019, Differences study on the main nutritional quality of longan vinegar before and after fermentation, Sci. Tech. Food Ind., 40, 19
  2. Descroix, 2010, New oligo-beta-(1,3)-glucan derivatives as immunostimulating agents, bioorgan, Med. Chem., 18, 348

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Metadata

Authors
Hu, T.-G., Zhu, W.-L., Yu, Y.-S., Zou, B., Xu, Y.-J., Xiao, G.-S., & Wu, J.-J.
Affiliations
Guangdong Academy of Agricultural Sciences (CN)
Corresponding author
Yu, Yuan-Shan
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2022-12
Volume
222
Issue
Pt A
Pages
599-609
ISSN
0141-8130 (ISSN-L)
OpenAlex
W4297158737
Cited by
81
References
49
Citations by year
2026: 24 · 2025: 22 · 2024: 17 · 2023: 17 · 2022: 1
FWCI
7.58
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • South China University of Technology (KJYS2021KZ05)
  • Special Project for Research and Development in Key areas of Guangdong Province (2020B0202080003, 2022B0202040002)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Health Sciences › Medicine › Pharmacology (medical) › Fungal Biology and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
fermentation, polysaccharide structure, immunomodulatory activity, structure-activity relationship, molecular weight, mannose, rhamnose, arabinose, glucuronic acid, cytokine production, MAPK signaling, PI3K/Akt signaling, polysaccharide purification
MeSH terms
Arabinose, Fermentation, Glucose, Mannose, Polysaccharides, Rhamnose, Acetic Acid, Phosphatidylinositol 3-Kinases, Sapindaceae

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