Cited by 13Radiation Therapy and DosimetryNanoplatforms for cancer theranosticsPolymer Nanocomposite Synthesis and Irradiation

Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer

Mousazadeh, Navid, Seidi, Farzad, Ghaffarlou, Mohammadreza, Rashidzadeh, Hamid, Hosseinmirzaei, Ali, Mozafari, Faezeh, Danafar, Hossein, Nosrati, Hamed·2023·International Journal of Biological Macromolecules

Abstract

A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (Ag 2 S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV-vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively. Moreover, the hemolysis assay demonstrated that the nanoparticles were biocompatible and nontoxic. In vitro intracellular ROS generation and calcein AM/PI co-staining unveiled cancerous cell death induction by nanoradiosensitizer, Ag 2 S@Alg. Further, histopathology results emphasized the tumor ablation capability of Ag 2 S@Alg. Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation.

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Crossref · 10.1016/j.ijbiomac.2023.123636

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Authors
Mousazadeh, N., Seidi, F., Ghaffarlou, M., Rashidzadeh, H., Hosseinmirzaei, A., Mozafari, F., Danafar, H., & Nosrati, H.
Affiliations
  • Zanjan University of Medical Sciences (IR)
  • Nanjing Forestry University (CN)
  • Hacettepe University (TR)
Corresponding author
  • Seidi, Farzad
  • Danafar, Hossein
  • Nosrati, Hamed
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2023-04
Volume
234
Pages
123636
ISSN
0141-8130 (ISSN-L)
OpenAlex
W4319869908
Cited by
13
References
62
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 1
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute for Medical Research Development (4000521)
  • Zanjan University of Medical Sciences
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Nanocomposite Synthesis and Irradiation
Keywords
silver sulfide nanoparticles, alginate coating, radiosensitizers, X-ray therapy, breast cancer, reactive oxygen species, nanoparticle cytotoxicity, hemolysis, MCF-7 cells, 4T1 cells, tumor ablation, biocompatibility
MeSH terms
Alginates, Breast Neoplasms, Female, Humans, X-Rays, Reactive Oxygen Species, Spectroscopy, Fourier Transform Infrared, Silver Compounds, Metal Nanoparticles

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