Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer
Abstract
A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (Ag 2 S@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV-vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively. Moreover, the hemolysis assay demonstrated that the nanoparticles were biocompatible and nontoxic. In vitro intracellular ROS generation and calcein AM/PI co-staining unveiled cancerous cell death induction by nanoradiosensitizer, Ag 2 S@Alg. Further, histopathology results emphasized the tumor ablation capability of Ag 2 S@Alg. Silver anticancer properties were also recognized and combined with its radiosensitizing effect under X-ray irradiation.
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Therapeutic payload delivery, including chemotherapeutic agents, epigenetic modulators, and nucleic acid-based therapeutics, was commonly described in the included studies.
“Therapeutic payload delivery was also commonly described, including chemotherapeutic agents, epigenetic modulators, and nucleic acid-based therapeutics [27,42,45,52,71,72,73].”
From Nanoparticle-Mediated Radiosensitization in Breast Cancer: A Systematic Review of Preclinical Evidence and Translational Challenges (2026) · cites this paper as [73]
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Lunca, S., Morarasu, S., & Dimofte, G. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146522 · Cited by 2 · see citing works
“Therapeutic payload delivery was also commonly described, including chemotherapeutic agents, epigenetic modulators, and nucleic acid-based therapeutics [27,42,45,52,71–73].”
- Authors
- Mousazadeh, N., Seidi, F., Ghaffarlou, M., Rashidzadeh, H., Hosseinmirzaei, A., Mozafari, F., Danafar, H., & Nosrati, H.
- Affiliations
- Zanjan University of Medical Sciences (IR)
- Nanjing Forestry University (CN)
- Hacettepe University (TR)
- Corresponding author
- Seidi, Farzad
- Danafar, Hossein
- Nosrati, Hamed
- ORCID
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 234
- Pages
- 123636
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4319869908
- Cited by
- 13
- References
- 62
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Medical Research Development (4000521)
- Zanjan University of Medical Sciences
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer Nanocomposite Synthesis and Irradiation
- Keywords
- silver sulfide nanoparticles, alginate coating, radiosensitizers, X-ray therapy, breast cancer, reactive oxygen species, nanoparticle cytotoxicity, hemolysis, MCF-7 cells, 4T1 cells, tumor ablation, biocompatibility
- MeSH terms
- Alginates, Breast Neoplasms, Female, Humans, X-Rays, Reactive Oxygen Species, Spectroscopy, Fourier Transform Infrared, Silver Compounds, Metal Nanoparticles
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