Inhibitory effect of Dendrobium officinale polysaccharide on oxidative damage of glial cells in aging mice by regulating gut microbiota
Abstract
Polysaccharides extracted from Dendrobium officinale have various physiological effects. In this study, we used D-galactose-induced senescent mice as an animal model to investigate the inhibitory effects of Dendrobium officinale polysaccharide (DOP) on oxidative damage in glial cells by attenuating oxidative stress and modulating the gut microbiota. The results showed that DOP significantly alleviated the activation of glial cells, increased the activity of antioxidant enzymes and reduced the MDA content in senescent mice. In addition, DOP reshaped the disordered gut microbiota, decreased the abundance ratio of Firmicutes to Bacteroidetes and increased the abundance of beneficial bacteria Lactobacillus. DOP may reverse the gut microbiota disturbance and alleviate the oxidative damage of glial cells, therefore exert potential neuroprotective effects by modulating gut microbiota.
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Gut microbiota manipulation is linked to alterations in astrocytic proliferation and functions.
“Gut microbiota manipulation has also been linked to alterations in astrocytic proliferation and functions.253–256”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [255]
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Self-citation
- Authors
- Xu, L., Zeng, X., Liu, Y., Wu, Z., Zheng, X., & Zhang, X.
- Affiliations
- Ningbo University (CN)
- Nanjing Agricultural University (CN)
- Wenzhou Vocational College of Science and Technology (CN)
- Corresponding author
- Zeng, Xiaoxiong
- Zheng, Xiaojie
- Zhang, Xin
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 247
- Pages
- 125787
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4383823138
- Cited by
- 65
- References
- 72
- Citations by year
- 2026: 20 · 2025: 27 · 2024: 14 · 2023: 4
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Ningbo (2022J073)
- Topics
- Health Sciences › Medicine › Pharmacology › Biological and pharmacological studies of plants
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Dendrobium officinale polysaccharide, aging, D-galactose-induced aging, gut microbiota, oxidative stress, antioxidant enzymes, lipid peroxidation, MDA, Firmicutes/Bacteroidetes ratio, Lactobacillus, neuroprotection, neuroinflammation
- MeSH terms
- Gastrointestinal Microbiome, Aging, Animals, Neuroglia, Polysaccharides, Oxidative Stress, Dendrobium, Mice
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