Cited by 65Biological and pharmacological studies of plantsAntioxidants, Aging, Portulaca oleraceaGut microbiota and health

Inhibitory effect of Dendrobium officinale polysaccharide on oxidative damage of glial cells in aging mice by regulating gut microbiota

Xu, Lei, Zeng, Xiaoxiong, Liu, Yanan, Wu, Zufang, Zheng, Xiaojie, Zhang, Xin·2023·International Journal of Biological Macromolecules

Abstract

Polysaccharides extracted from Dendrobium officinale have various physiological effects. In this study, we used D-galactose-induced senescent mice as an animal model to investigate the inhibitory effects of Dendrobium officinale polysaccharide (DOP) on oxidative damage in glial cells by attenuating oxidative stress and modulating the gut microbiota. The results showed that DOP significantly alleviated the activation of glial cells, increased the activity of antioxidant enzymes and reduced the MDA content in senescent mice. In addition, DOP reshaped the disordered gut microbiota, decreased the abundance ratio of Firmicutes to Bacteroidetes and increased the abundance of beneficial bacteria Lactobacillus. DOP may reverse the gut microbiota disturbance and alleviate the oxidative damage of glial cells, therefore exert potential neuroprotective effects by modulating gut microbiota.

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Crossref · 10.1016/j.ijbiomac.2023.125787

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Authors
Xu, L., Zeng, X., Liu, Y., Wu, Z., Zheng, X., & Zhang, X.
Affiliations
  • Ningbo University (CN)
  • Nanjing Agricultural University (CN)
  • Wenzhou Vocational College of Science and Technology (CN)
Corresponding author
  • Zeng, Xiaoxiong
  • Zheng, Xiaojie
  • Zhang, Xin
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2023-08
Volume
247
Pages
125787
ISSN
0141-8130 (ISSN-L)
OpenAlex
W4383823138
Cited by
65
References
72
Citations by year
2026: 20 · 2025: 27 · 2024: 14 · 2023: 4
FWCI
10.15
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Ningbo (2022J073)
Topics
  • Health Sciences › Medicine › Pharmacology › Biological and pharmacological studies of plants
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Dendrobium officinale polysaccharide, aging, D-galactose-induced aging, gut microbiota, oxidative stress, antioxidant enzymes, lipid peroxidation, MDA, Firmicutes/Bacteroidetes ratio, Lactobacillus, neuroprotection, neuroinflammation
MeSH terms
Gastrointestinal Microbiome, Aging, Animals, Neuroglia, Polysaccharides, Oxidative Stress, Dendrobium, Mice

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