The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Copper peroxide-loaded lignin-based non-isocyanate polyurethane foam for wound repair applications
Abstract
Wound healing is a complex process and the mechanism of the tissue repair process involves many complex steps: inflammation, proliferation, and maturation. Wounds can be divided into two main categories: acute and chronic wounds. Non-healing wounds usually follow a bacterial infection. Many types of materials on the market have been developed for use as wound dressings. Polyurethane foam for wound dressings has many advantages over other materials, especially for moderate wounds and drainage. In this study, lignin-based non-isocyanate polyurethane foams were prepared using a green route by oxygen alkylation modification of enzymatically dissolved lignin, cyclic carbonation and polymerization with diamines to add a blowing agent. By loading CuO 2 on the surface of the prepared lignin-based non-isocyanate polyurethane foam, a pH-responsive wound dressing, named lignin-based non-isocyanate polyurethane/copper peroxide composite foam (named NIPU foam-CuO 2), was prepared, which can specifically release the strong oxidizing OH under acidic conditions. The composite foam can effectively kill the bacteria in the wound. The test results proved that the composite foam has excellent mechanical properties, thermal stability, and biocompatibility. NIPU-foam-CuO 2 100 mM inhibited two types of bacteria, Escherichia coli, and Staphylococcus aureus, by up to 98 % and 95 % within 8 h, respectively. It also shows excellent performance in promoting wound healing in organism experiments as well as in the subsequent histological staining. The lignin-based NIPU foams of this work exhibit remarkable innovation and unique properties in terms of environmental friendliness, performance and antimicrobial resistance. At the same time, we also mention potential problems such as drug resistance in the long-term use of NIPU-CuO 2 foams.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These studies consistently demonstrate enhanced healing of non-infected wounds [71,72,73,74,75,76], including those in diabetic [77,78,79,80,81,82,83] and burn-related [84,85,86,87,88,89,90] animal models when compared to control materials.”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [74]
Citations
Cites
Synthesis of Copper Peroxide Nanodots for H 2 O 2 Self-Supplying Chemodynamic Therapy
Lin, L., Huang, T., Song, J., Ou, X., Wang, Z., Deng, H., Tian, R., Liu, Y., Wang, J., Liu, Y., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03457 · Cited by 1,129
Gold Nanocages: From Synthesis to Theranostic Applications
Younan Xia, A., Li, W., Cobley, C. M., Chen, J., Xia, X., Zhang, Q., Yang, M., Cho, E. C., & Brown, P. (2011) · Accounts of Chemical Research · doi:10.1021/ar200061q · Cited by 810
Self-citationAntimicrobial Nano-Agents: The Copper Age
Ermini, M. L., & Voliani, V. (2021) · ACS Nano · doi:10.1021/acsnano.0c10756 · Cited by 493
Non‐isocyanate polyurethanes: synthesis, properties, and applications
Rokicki, G., Parzuchowski, P. G., & Mazurek‐Budzyńska, M. (2015) · Polymers for Advanced Technologies · doi:10.1002/pat.3522 · Cited by 441
Choosing a Wound Dressing Based on Common Wound Characteristics
Dabiri, G., Damstetter, E. M., & Phillips, T. J. (2014) · Advances in Wound Care · doi:10.1089/wound.2014.0586 · Cited by 413
Trends in non-isocyanate polyurethane (NIPU) development
Gomez‐Lopez, A., Elizalde, F., Calvo, I., & Sardón, H. (2021) · Chemical Communications · doi:10.1039/d1cc05009e · Cited by 219
An “On‐Site Transformation” Strategy for Treatment of Bacterial Infection
Qi, G., Zhang, D., Liu, F., Qiao, Z., & Wang, H. (2017) · Advanced Materials · doi:10.1002/adma.201703461 · Cited by 197
Biomedical applications of copper ionophores
Oliveri, V. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213474 · Cited by 175
Preparation of lignin/glycerol-based bis(cyclic carbonate) for the synthesis of polyurethanes
Chen, Q., Gao, K., Peng, C., Xie, H., Zhao, Z. K., & Bao, M. (2015) · Green Chemistry · doi:10.1039/c5gc01340b · Cited by 118
Hemostatic kaolin-polyurethane foam composites for multifunctional wound dressing applications
Lundin, J. G., McGann, C. L., Daniels, G. C., Streifel, B. C., & Wynne, J. H. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.05.084 · Cited by 89
Synthesis and characterization of lignin-polyurethane based wood adhesive
Gadhave, R. V. I., Kasbe, P. S., Mahanwar, P. A., & Gadekar, P. T. (2019) · International Journal of Adhesion and Adhesives · doi:10.1016/j.ijadhadh.2019.102427 · Cited by 85
Lignin Modifications, Applications, and Possible Market Prices
Nadányi, R., Ház, A., Lisý, A., Jablonský, M., Šurina, I., Majová, V., & Baco, A. (2022) · Energies · doi:10.3390/en15186520 · Cited by 83
An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
Liang, W., Ni, N., Huang, Y., & Lin, C. (2023) · Polymers · doi:10.3390/polym15214301 · Cited by 72
Jian, Z., Wang, H., Liu, M., Chen, S., Wang, Z., Qian, W., Luo, G., & Xia, H. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110833 · Cited by 71
Antibacterial and angiogenic wound dressings for chronic persistent skin injury
Wang, Z., Hu, W., You, W., Huang, G., Tian, W., Huselstein, C., Wu, C., Xiao, Y., Chen, Y., & Wang, X. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.126525 · Cited by 71
Formate-assisted analytical pyrolysis of kraft lignin to phenols
Wang, W., Wang, M., Huang, J., Zhao, X., Su, Y., Wang, Y., & Li, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.01.078 · Cited by 61
Self-citationThe advancement of intelligent dressings for monitoring chronic wound infections
Wang, X., Zhong, B., Lou, Z., Han, W., & Wang, L. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149643 · Cited by 58
Gholami, H., & Yeganeh, H. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110142 · Cited by 54
Polyurethane foams chemically reinforced with POSS—Thermal degradation studies
Pagacz, J., Hebda, E., Michałowski, S., Ozimek, J., Sternik, D., & Pielichowski, K. (2016) · Thermochimica Acta · doi:10.1016/j.tca.2016.09.006 · Cited by 53
Choi, H. J., Thambi, T., Yang, Y. H., Bang, S. I., Kim, B. S., Pyun, D. G., & Lee, D. S. (2017) · RSC Advances · doi:10.1039/c6ra27322j · Cited by 51
Guiding the Path to Healing: CuO 2 ‐Laden Nanocomposite Membrane for Diabetic Wound Treatment
Qi, L., Huang, Y. X., Sun, D., Liu, Z., Jiang, Y., Liu, J., Wang, J., Liu, L., Feng, G., Li, Y., et al. (2023) · Small · doi:10.1002/smll.202305100 · Cited by 43
A New Environmentally Friendly Approach to Lignin‐Based Cyclic Carbonates
Kühnel, I., Saake, B., & Lehnen, R. (2018) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201700613 · Cited by 42
Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics
Chowdhury, F. R., & Findlay, B. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00156 · Cited by 42
Kumari, A., Sahoo, J., & De, M. (2023) · Nanoscale · doi:10.1039/d3nr05458f · Cited by 37
Copper catalysis for highly selective aerobic oxidation of alcohols to aldehydes/ketones
Zhai, D., & Ma, S. (2019) · Organic Chemistry Frontiers · doi:10.1039/c9qo00740g · Cited by 33
Grzęda, D., Węgrzyk, G., Nowak, A., Idaszek, J., Szczepkowski, L., & Ryszkowska, J. (2023) · Polymers · doi:10.3390/polym15122754 · Cited by 18
Removal of cyanide in aqueous solution by oxidation with hydrogen peroxide catalyzed by copper oxide
Amaouche, H., Chergui, S., Halet, F., Yeddou, A. R., Chergui, A., Nadjemi, B., & Ould‐Dris, A. (2019) · Water Science & Technology · doi:10.2166/wst.2019.254 · Cited by 17
Margatho, A. S., Ciol, M. A., Hoffman, J. M., dos Reis, P. E. D., Furuya, R. K., Lima, D. A. F. S., Basile-Filho, A., & Silveira, R. C. D. C. P. (2018) · Australian Critical Care · doi:10.1016/j.aucc.2018.11.001 · Cited by 16
Hsu, S., Xu, J., Lin, S., Wu, S., Cheng, Q., & Wong, C. (2022) · Journal of Polymer Research · doi:10.1007/s10965-022-02919-5 · Cited by 14
Carayon, I., Szarlej, P., Gnatowski, P., Piłat, E., Sienkiewicz, M., Glinka, M., Karczewski, J. L., & Kucińska‐Lipka, J. (2022) · Advances in Medical Sciences · doi:10.1016/j.advms.2022.05.003 · Cited by 12
Siavash, M., & Noursina, A. (2023) · Burns · doi:10.1016/j.burns.2023.04.007 · Cited by 11
Chaiarwut, S., Choipang, C., Sangsanoh, P., Niyompanich, J., & Supaphol, P. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-022-02684-y · Cited by 7
Hydroxyl Radical Generating Monovalent Copper Particles for Antimicrobial Application
Tan, T. H., Zhang, H., Xie, B., Mann, R., Peng, L., Yun, S. L. J., Amal, R., Gu, Z., & Gunawan, C. (2023) · Journal of Nanomaterials · doi:10.1155/2023/8812824 · Cited by 3
Research works printed but not linked: 7
- Wendels, 2021, Biobased polyurethanes for biomedical applications[J], Bioact. Mater., 6, 1083
- Sheng, 2023, Retracted: porcine fibrin sealant promotes skin wound healing in rats[J], Evid. Based Complement. Alternat. Med., 1
- Memar, 2018, Antimicrobial use of reactive oxygen therapy: current insights[J], Infect. Drug Resist., 11, 67
- GianinoE, 2018, Smart wound dressings for dabetic chronic wounds[J], Bioengineering, 5, 184
- Landay, 2017, Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - a feasibility study[J], PLoS One, 12, 114
- Wang, 2022, Copper peroxides based multiple tumor microenvironment regulation for enhanced photodynamic/chemodynamic synergistic therapy[J], Adv. Opt. Mater., 11, 101
- Cao, 2024, Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing[J], Mater. Today Phys., 40, 88
Cited by
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24
Non-isocyanate polyurethanes: perspectives as biomaterials
Pierrard, A., Melo, S. F., Oury, C., Detrembleur, C., & Jérôme, C. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.113985 · Cited by 23
Jin, L., Zhao, W., Feng, Z., Ni, Y., & Hadjichristidis, N. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202515569 · Cited by 13
Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects
Watt, A., Rachella, C., Jaloux, C., Vorstenbosch, J., Hart, A., Tänzer, M., Merle, G. E., & Barralet, J. E. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505259 · Cited by 14
Polyurethane Foams in Medical Devices: A Brief Review
Xu, J., Dai, X., Yang, Y., Chen, J., Han, L., & Zhang, R. (2026) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202500449 · Cited by 6
Self-citation
Metadata
- Authors
- Quan, M., Li, J., Cui, M., Sha, G., Wang, Y., Wu, B., Zhu, J., & Chen, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Zhejiang University of Technology (CN)
- Corresponding author
- Wu, Bozhen
- Chen, Jing
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2025-02
- Volume
- 288
- Pages
- 138733
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4405402690
- Cited by
- 14
- References
- 33
- Citations by year
- 2026: 8 · 2025: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2017YFE0102300)
- National Natural Science Foundation of China (U23A20691, U21B2093)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- copper peroxide, wound dressings, wound healing, pH-responsive drug release, hydrogen peroxide release, antimicrobial activity, Escherichia coli, Staphylococcus aureus, green synthesis, chronic wounds, biocompatibility
- MeSH terms
- Animals, Anti-Bacterial Agents, Bandages, Biocompatible Materials, Copper, Escherichia coli, Lignin, Peroxides, Polyurethanes, Staphylococcus aureus, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
