The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Copper peroxide-loaded lignin-based non-isocyanate polyurethane foam for wound repair applications
Abstract
Wound healing is a complex process and the mechanism of the tissue repair process involves many complex steps: inflammation, proliferation, and maturation. Wounds can be divided into two main categories: acute and chronic wounds. Non-healing wounds usually follow a bacterial infection. Many types of materials on the market have been developed for use as wound dressings. Polyurethane foam for wound dressings has many advantages over other materials, especially for moderate wounds and drainage. In this study, lignin-based non-isocyanate polyurethane foams were prepared using a green route by oxygen alkylation modification of enzymatically dissolved lignin, cyclic carbonation and polymerization with diamines to add a blowing agent. By loading CuO 2 on the surface of the prepared lignin-based non-isocyanate polyurethane foam, a pH-responsive wound dressing, named lignin-based non-isocyanate polyurethane/copper peroxide composite foam (named NIPU foam-CuO 2), was prepared, which can specifically release the strong oxidizing OH under acidic conditions. The composite foam can effectively kill the bacteria in the wound. The test results proved that the composite foam has excellent mechanical properties, thermal stability, and biocompatibility. NIPU-foam-CuO 2 100 mM inhibited two types of bacteria, Escherichia coli, and Staphylococcus aureus, by up to 98 % and 95 % within 8 h, respectively. It also shows excellent performance in promoting wound healing in organism experiments as well as in the subsequent histological staining. The lignin-based NIPU foams of this work exhibit remarkable innovation and unique properties in terms of environmental friendliness, performance and antimicrobial resistance. At the same time, we also mention potential problems such as drug resistance in the long-term use of NIPU-CuO 2 foams.
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“These studies consistently demonstrate enhanced healing of non-infected wounds [71,72,73,74,75,76], including those in diabetic [77,78,79,80,81,82,83] and burn-related [84,85,86,87,88,89,90] animal models when compared to control materials.”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [74]
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Cites
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Cited by
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24
Non-isocyanate polyurethanes: perspectives as biomaterials
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Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects
Watt, A., Rachella, C., Jaloux, C., Vorstenbosch, J., Hart, A., Tänzer, M., Merle, G. E., & Barralet, J. E. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505259 · Cited by 14
Polyurethane Foams in Medical Devices: A Brief Review
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Self-citation
Metadata
- Authors
- Quan, M., Li, J., Cui, M., Sha, G., Wang, Y., Wu, B., Zhu, J., & Chen, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Zhejiang University of Technology (CN)
- Corresponding author
- Wu, Bozhen
- Chen, Jing
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2025-02
- Volume
- 288
- Pages
- 138733
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W4405402690
- Cited by
- 14
- References
- 33
- Citations by year
- 2026: 8 · 2025: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2017YFE0102300)
- National Natural Science Foundation of China (U23A20691, U21B2093)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- copper peroxide, wound dressings, wound healing, pH-responsive drug release, hydrogen peroxide release, antimicrobial activity, Escherichia coli, Staphylococcus aureus, green synthesis, chronic wounds, biocompatibility
- MeSH terms
- Animals, Anti-Bacterial Agents, Bandages, Biocompatible Materials, Copper, Escherichia coli, Lignin, Peroxides, Polyurethanes, Staphylococcus aureus, Wound Healing
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