Increased levels of C-reactive protein and fibrinogen influence the risk of vascular events in patients with NIDDM
Abstract
Aim To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes.Methods We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death.Results During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events.Conclusion Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.
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The 1.8-fold decrease in hsCRP may translate into reduction in residual cardiovascular risk.
“which may translate into reduction in residual cardiovascular risk”
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Maes, M. (2006) · UA Campus Repository (The University of Arizona)
- Authors
- Coppola, G., Corrado, E., Muratori, I., Tantillo, R., Vitale, G., Lo Coco, L., & Novo, S.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Coppola, Giuseppe
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 106
- Issue
- 1
- Pages
- 16-20
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W1984742370
- Cited by
- 55
- References
- 35
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- type 2 diabetes, C-reactive protein, fibrinogen, cardiovascular risk prediction, vascular events, ischemic stroke, myocardial infarction, carotid artery disease, obesity, critical limb ischemia, cardiovascular mortality
- MeSH terms
- Aged, C-Reactive Protein, Cardiovascular Diseases, Cerebrovascular Disorders, Diabetes Mellitus, Type 2, Female, Fibrinogen, Humans, Male, Risk Factors, Prevalence, Chi-Square Distribution, Case-Control Studies
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