Cited by 55Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesLipoproteins and Cardiovascular Health

Increased levels of C-reactive protein and fibrinogen influence the risk of vascular events in patients with NIDDM

Coppola, Giuseppe, Corrado, Egle, Muratori, Ida, Tantillo, Rosalba, Vitale, Giustina, Lo Coco, L., Novo, Salvatore·2006·International Journal of Cardiology

Abstract

Aim To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes.Methods We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death.Results During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events.Conclusion Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.

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Crossref · 10.1016/j.ijcard.2004.12.051

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Authors
Coppola, G., Corrado, E., Muratori, I., Tantillo, R., Vitale, G., Lo Coco, L., & Novo, S.
Affiliations
University of Palermo (IT)
Corresponding author
Coppola, Giuseppe
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2006-01
Volume
106
Issue
1
Pages
16-20
ISSN
0167-5273 (ISSN-L)
OpenAlex
W1984742370
Cited by
55
References
35
Citations by year
2026: 1 · 2024: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
type 2 diabetes, C-reactive protein, fibrinogen, cardiovascular risk prediction, vascular events, ischemic stroke, myocardial infarction, carotid artery disease, obesity, critical limb ischemia, cardiovascular mortality
MeSH terms
Aged, C-Reactive Protein, Cardiovascular Diseases, Cerebrovascular Disorders, Diabetes Mellitus, Type 2, Female, Fibrinogen, Humans, Male, Risk Factors, Prevalence, Chi-Square Distribution, Case-Control Studies

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