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Cited by 66Viral Infections and Immunology ResearchCardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

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Autoantibodies to cardiac troponin I in patients with idiopathic dilated and ischemic cardiomyopathy

Shmilovich, Haim, Danon, Asaf, Binah, Ofer, Roth, Arie, Chen, Gerald, Wexler, Dov, Keren, Gad, George, Jacob·2007·International Journal of Cardiology
DOI 10.1016/j.ijcard.2006.04.077
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Abstract

Background Progressive dilatation and functional compromise of heart function is attributed to a variety of pathogenic mechanisms. Experimental data suggests that autoantibodies could promote myocardial damage by inducing either inflammation or alternatively, augmentation of Ca2+ currents or activation of surface receptors on cardiomyocytes. Cardiac troponin I (cTpnI) is an essential protein component of the contractile heart. Herein, we studied the presence and functional properties of autoantibodies to cTpnI in patients with idiopathic dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM). Methods and results Anti-cTpnI antibody ELISA was established for assessment of sera obtained from 33 patients with ICM, 32 with DCM and 42 healthy subjects. Binding specificity of purified cTpnI-reactive IgG fractions from patients with ICM and DCM was confirmed by competitive inhibition studies employing fluid-phase cTpnI. The effect of IgG preparations on intracellular Ca2+ ([Ca2+]i) transients was tested in cultured neonatal rat ventricular myocytes (NRVM). Six of the 33 ICM patients (18.2%) and 5 of the 32 DCM patients (15.6%) had positive anti-cTpnI antibody titer as compared to none in the healthy subjects. Purified IgG from positive patients appeared specific to cTpnI. IgG preparations reactive with cTpnI did not exhibit measurable effects on [Ca2+]i transients in cultured NRVM nor did they bind the respective cells by direct immunofluorescence. Conclusion IgG antibodies…

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  • A detectable level of anti-cTnI autoantibodies in the serum of patients with idiopathic cardiomyopathy or DCM has been observed.

    “a detectable level of anti-cTnI autoantibodies in the serum of patients with idiopathic cardiomyopathy or DCM has been observed”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [99]

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Metadata

Authors
Shmilovich, H., Danon, A., Binah, O., Roth, A., Chen, G., Wexler, D., Keren, G., & George, J.
Affiliations
  • Tel Aviv University (IL)
  • Technion – Israel Institute of Technology (IL)
Corresponding author
George, Jacob
ORCID
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2007-04
Volume
117
Issue
2
Pages
198-203
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/j.ijcard.2006.04.077
OpenAlex
W2100812517
Cited by
66
References
1
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 2
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
autoantibodies, cardiac troponin I, idiopathic dilated cardiomyopathy, ischemic cardiomyopathy, calcium transients, ventricular myocytes, myocardial injury
MeSH terms
Adult, Aged, Animals, Autoantibodies, Calcium, Cardiomyopathy, Dilated, Cells, Cultured, Female, Fluorescent Dyes, Humans, Immunoglobulin G, Male, Middle Aged, Fura-2, Myocardial Ischemia, Rats, Sprague-Dawley, Troponin I, Myocytes, Cardiac, Rats

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