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Cited by 127Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsMuscle metabolism and nutrition

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Short-term effects of l-citrulline supplementation on arterial stiffness in middle-aged men

Ochiai, Masayuki, Hayashi, Toshio, Morita, Masahiko, Ina, Koichiro, Maeda, Morihiko, Watanabe, Fumiko, Morishita, Koji·2012·International Journal of Cardiology
DOI 10.1016/j.ijcard.2010.10.004
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Abstract

Background Nitric oxide (NO) plays a key role in the maintenance of vascular tone, contributing to the functional regulation of arterial stiffness. Although oral L-citrulline could become the effective precursor of L-arginine (substrate for endothelial NO synthase) via the L-citrulline/ L-arginine pathway, little is known about the efficacy of L-citrulline application on arterial stiffness.Objective We examined the short-term effects of L-citrulline supplementation on arterial stiffness in humans.Methods In a double-blind, randomized, placebo-controlled parallel-group trial, 15 healthy male subjects (age: 58.3 ± 4.4 years) with brachial-ankle pulse wave velocity (baPWV; index of arterial stiffness >1400 cm/sec) were given 5.6g/day of L-citrulline (n=8) or placebo (n=7) for 7 days. baPWV and various clinical parameters were measured before (baseline) and after oral supplementation of L-citrulline or placebo.Results Compared with the placebo group, baPWV was significantly reduced in the L-citrulline group (p<0.01). No significant differences in blood pressure (BP) were found between the two groups, and no correlation was observed between BP and baPWV. The serum nitrogen oxide (NOx, the sum of nitrite plus nitrate) and NO metabolic products were significantly increased only in the L-citrulline group (p<0.05). Plasma citrulline, arginine and the ratio of arginine/asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (arginine/ADMA ratio) were significantly increased in the L-citrulline group compared with the placebo group (p<0.05, p<0.01, p<0.05, respectively). Moreover, there was a correlation between the increase of plasma arginine and the reduction of baPWV (r=-0.553, p<0.05).Conclusion These findings suggest that short-term L-citrulline supplementation may functionally improve arterial stiffness, independent of blood pressure, in humans.

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Research works printed but not linked: 1

  1. Hecker, 1990, The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine, Proc Natl Acad Sci USA, 87, 8612, 10.1073/pnas.87.21.8612 · DOI

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Metadata

Authors
Ochiai, M., Hayashi, T., Morita, M., Ina, K., Maeda, M., Watanabe, F., & Morishita, K.
Affiliations
Nagoya University (JP)
Corresponding author
Hayashi, Toshio
ORCID
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2012-03
Volume
155
Issue
2
Pages
257-261
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/j.ijcard.2010.10.004
OpenAlex
W2052898997
Cited by
127
References
29
Citations by year
2026: 9 · 2025: 9 · 2024: 3 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 6
FWCI
2.85
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21590762, 20406004)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
L-citrulline supplementation, arterial stiffness, brachial-ankle pulse wave velocity, nitric oxide, L-arginine, asymmetric dimethylarginine, endothelial nitric oxide synthase, middle-aged men, blood pressure
MeSH terms
Arginine, Blood Pressure, Citrulline, Humans, Male, Middle Aged, Nitric Oxide, Placebos, Pulsatile Flow, Nitric Oxide Synthase Type III, Ankle Brachial Index, Vascular Stiffness

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