Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354 · see citing works

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827 · see citing works

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

Vallance, P., Collier, J., & Moncada, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91013-1 · Cited by 1,590 · see citing works

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

Hibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 938 · see citing works

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

Feelisch, M., & Noack, E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90493-6 · Cited by 887 · see citing works

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from l -arginine.

Liew, F. Y., Millott, S. M., Parkinson, C., Palmer, R. M. J., & Moncada, S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.12.4794 · Cited by 736 · see citing works

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

Rosa, M. D., Radomski, M. W., Carnuccio, R., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91583-e · Cited by 454 · see citing works

NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?

Aisaka, K., Gross, S. S., Griffith, O. W., & Levi, R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92517-5 · Cited by 427 · see citing works

Isolation and Identification of N,N- and N,N' -Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human Urine

Kakimoto, Y., & Akazawa, S. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62716-4 · Cited by 409 · see citing works

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

Ogawa, T., Kimoto, M., & Sasaoka, K. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81786-0 · Cited by 364 · see citing works

Studies on the catabolism of NG-methylarginine, NG, NG-dimethylarginine and NG, NG-dimethylarginine in the rabbit

MCDERMOTT, J. R. (1976) · Biochemical Journal · doi:10.1042/bj1540179 · Cited by 194 · see citing works

Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine

Granger, D. L., Hibbs, J. B., & Broadnax, L. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1294 · Cited by 144 · see citing works

Effects of amino acid infusion on renal hemodynamics. Role of endothelium-derived relaxing factor.

Tolins, J. P., & Raij, L. R. (1991) · Hypertension · doi:10.1161/01.hyp.17.6.1045 · Cited by 101 · see citing works

The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat

Walder, C. E., Thiemermann, C., & Vane, J. R. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12285.x · Cited by 98 · see citing works

Glucagon and prostaglandins are mediators of amino acid-induced rise in renal hemodynamics

Hirschberg, R. R., Zipser, R. D., Slomowitz, L. A., et al. (1988) · Kidney International · doi:10.1038/ki.1988.123 · Cited by 88 · see citing works

Dimethylarginine:pyruvate aminotransferase in rats. Purification, properties, and identity with alanine:glyoxylate aminotransferase 2.

Ogawa, T., Kimoto, M., & Sasaoka, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45307-5 · Cited by 83 · see citing works

Isolation and identification of NG-Monomethyl NG, NG-Dimethyl- and NG,NG-Dimethylarginine from the hydrolysate of proteins of bovine brain

Nakajima, T., Matsuoka, Y., & Kakimoto, Y. (1971) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(71)90206-6 · Cited by 79 · see citing works

Uremia and Host Defenses

TOLKOFF-RUBIN, N. E., & Rubin, R. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003153221109 · Cited by 71 · see citing works

Determination of methylated amino acids in human serum by high-performance liquid chromatography

Park, K. S., Lee, H. W., Hong, S., et al. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)94526-6 · Cited by 48 · see citing works

Urinary excretion of methylarginine in human disease

CARNEGIE, P. R., Fellows, F. C. I., & Symington, G. R. (1977) · Metabolism · doi:10.1016/0026-0495(77)90097-x · Cited by 44 · see citing works

Host Defenses and Infectious Complications in Maintenance Hemodialysis Patients

Rinehart, A. L., Collins, A. J., & Keane, W. F. (2008) · Springer eBooks · doi:10.1007/978-0-585-36947-1_47 · Cited by 44 · see citing works

Human Muscular Dystrophy: Elevation of Urinary Dimethylarginines

Lou, M. F. (1979) · Science · doi:10.1126/science.760213 · Cited by 37 · see citing works

Effect of NG-monomethyl L-arginine on endothelium-dependent relaxation in arterioles of one-kidney, one clip hypertensive rats.

Nakamura, T., & Prewitt, R. L. (1991) · Hypertension · doi:10.1161/01.hyp.17.6.875 · Cited by 36 · see citing works

Host Defenses and Infectious Complications in Maintenance Hemodialysis Patients

Keane, W. F., & Raij, L. R. (1983) · Springer eBooks · doi:10.1007/978-94-009-6768-7_33 · Cited by 18 · see citing works

The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works

Nitric oxide synthases in mammals

Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752 · see citing works

Chronic Kidney Disease: Effects on the Cardiovascular System

Schiffrin, E. L., Lipman, M. L., & Mann, J. F. E. (2007) · Circulation · doi:10.1161/circulationaha.106.678342 · Cited by 1,448 · see citing works

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction: Its Role in Hypercholesterolemia

Böger, R. H., Bode-Böger, S. M., Szuba, A., Tsao, P. S., Chan, J. R., Tangphao, O., Blaschke, T. F., & Cooke, J. P. (1998) · Circulation · doi:10.1161/01.cir.98.18.1842 · Cited by 1,181 · see citing works

Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study

Zoccali, C., Bode-Böger, S. M., Mallamaci, F., Benedetto, F. A., Tripepi, G., Malatino, L. S., Cataliotti, A., Bellanuova, I., Fermo, I., Frölich, J. C., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07217-8 · Cited by 1,087 · see citing works

Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)

Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · see citing works

Age-Related Reduction of NO Availability and Oxidative Stress in Humans

Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664 · see citing works

Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine

Valkonen, V.-P., Päivä, H., Salonen, J. T., Lakka, T. A., Lehtimäki, T., Laakso, J., & Laaksonen, R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07184-7 · Cited by 562 · see citing works

Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway

Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses

Fernández-Macías, J. C., Ochoa-Martínez, A. C., Varela-Silva, J. A., & Pérez-Maldonado, I. N. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.08.009 · Cited by 458 · see citing works

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

Rochette, L., Lorin, J., Zeller, M., Guilland, J.-C., Lorgis, L., Cottin, Y., & Vergely, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.004 · Cited by 456 · see citing works

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

Leiper, J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00162-5 · Cited by 458 · see citing works

Molecular mechanisms underlying the activation of eNOS

Fleming, I. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0767-7 · Cited by 437 · see citing works

Asymmetrical Dimethylarginine: The Über Marker?

Cooke, J. P. (2004) · Circulation · doi:10.1161/01.cir.0000126823.07732.d5 · Cited by 396 · see citing works

Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Explains the “L-Arginine Paradox” and Acts as a Novel Cardiovascular Risk Factor

Böger, R. H. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.10.2842s · Cited by 363 · see citing works

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

Xu, W., Kaneko, F. T., Zheng, S., Comhair, S. A. A., Janocha, A. J., Goggans, T., Thunnissen, F. B. J. M., Farver, C., Hazen, S. L., Jennings, C., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2317fje · Cited by 369 · see citing works

Symmetric dimethylarginine (SDMA) as endogenous marker of renal function–a meta-analysis

Kielstein, J. T., Salpeter, S. R., Bode-Boeger, S. M., Cooke, J. P., & Fliser, D. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl292 · Cited by 363 · see citing works

Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community

Böger, R. H., Sullivan, L. M., Schwedhelm, E., Wang, T. J., Maas, R., Benjamin, E. J., Schulze, F., Xanthakis, V., Benndorf, R. A., & Vasan, R. S. (2009) · Circulation · doi:10.1161/circulationaha.108.838268 · Cited by 351 · see citing works

The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio

BODEBOGER, S., SCALERA, F., & IGNARRO, L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.002 · Cited by 347 · see citing works

Endothelium‐dependent contractions in hypertension

Vanhoutte, P. M., Feletou, M., & Taddei, S. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706042 · Cited by 284 · see citing works

<scp>l</scp> -Arginine Supplementation in Peripheral Arterial Disease: No Benefit and Possible Harm

Wilson, A. M., Harada, R., Nair, N., Balasubramanian, N., & Cooke, J. P. (2007) · Circulation · doi:10.1161/circulationaha.106.683656 · Cited by 241 · see citing works

Endogenous nitric oxide synthase inhibitors are responsible for the <scp>L</scp>‐arginine paradox

Tsikas, D., Böger, R. H., Sandmann, J., Bode-Böger, S. M., & Frölich, J. C. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01686-0 · Cited by 237 · see citing works

Effect of oral l-arginine supplementation on blood pressure: A meta-analysis of randomized, double-blind, placebo-controlled trials

Dong, J.-Y., Qin, L.-Q., Zhang, Z., Zhao, Y., Wang, J., Arigoni, F., & Zhang, W. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.09.012 · Cited by 227 · see citing works

Acute <scp>l</scp>-arginine supplementation reduces the O₂ cost of moderate-intensity exercise and enhances high-intensity exercise tolerance

Bailey, S. J., Winyard, P. G., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00503.2010 · Cited by 132 · see citing works

Short-term effects of l-citrulline supplementation on arterial stiffness in middle-aged men

Ochiai, M., Hayashi, T., Morita, M., Ina, K., Maeda, M., Watanabe, F., & Morishita, K. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.004 · Cited by 127 · see citing works

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis–mass spectrometry

González‐Domínguez, R., García, A., García‐Barrera, T., Barbas, C., & Gómez‐Ariza, J. L. (2014) · ELECTROPHORESIS · doi:10.1002/elps.201400196 · Cited by 119 · see citing works

Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?

N., C., & J., C. (2002) · Diabetologia · doi:10.1007/s00125-002-0975-6 · Cited by 116 · see citing works

Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease

Wilcock, D. M. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/170276 · Cited by 104 · see citing works

Aging of the Nitric Oxide System: Are We as Old as Our NO?

Sverdlov, A. L., Ngo, D. T. M., Chan, W. P. A., Chirkov, Y. Y., & Horowitz, J. D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000973 · Cited by 97 · see citing works

Biochemical responses of healthy subjects during dietary supplementation with L-arginine

Evans, R. W., Fernstrom, J. D., Thompson, J., Morris, S. M., & Kuller, L. H. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.03.005 · Cited by 97 · see citing works

Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease

Wang, J., Sim, A. S., Wang, X. L., Salonikas, C., Naidoo, D., & Wilcken, D. E. L. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.05.002 · Cited by 96 · see citing works

Salt Sensitivity in Blacks: Evidence That the Initial Pressor Effect of NaCl Involves Inhibition of Vasodilatation by Asymmetrical Dimethylarginine

Schmidlin, O., Forman, A., Leone, A., Sebastian, A., & Morris, R. C. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.170175 · Cited by 82 · see citing works

Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

Ueda, S., Yamagishi, S.-I., Matsumoto, Y., Fukami, K., & Okuda, S. (2007) · Clinical and Experimental Nephrology · doi:10.1007/s10157-007-0471-x · Cited by 65 · see citing works

Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA).

Siervo, M., Corander, M., Stranges, S., & Bluck, L. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.003 · Cited by 55 · see citing works

Free radicals (nitric oxide)

Kostka, P. (1995) · Analytical Chemistry · doi:10.1021/ac00108a023 · Cited by 38 · see citing works

Cellular interactions between L-arginine and asymmetric dimethylarginine: Transport and metabolism

Shin, S., Thapa, S. K., & Fung, H.-L. (2017) · PLOS ONE · doi:10.1371/journal.pone.0178710 · Cited by 28 · see citing works

Elevated Plasma Concentration of Asymmetric Dimethylarginine That Is Reduced by Single Dose Testosterone Administration in Idiopathic Hypogonadotropic Hypogonadism Patients

Cakir, E., Ozcan, O., Yaman, H., Akgul, E. O., Bilgi, C., Erbil, M. K., & Yesilova, Z. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-2045 · Cited by 28 · see citing works

l-Arginine is related to endothelium-dependent vasodilation in resistance and conduit arteries in divergent ways—The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study

Lind, L., Larsson, A., & Teerlink, T. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.016 · Cited by 17 · see citing works

Neuronal nitric oxide synthase immunohistochemistry and 4,5-diaminofluorescein diacetate: tools for nitric oxide research

Kasim, N., Branton, R. L., & Clarke, D. J. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00387-9 · Cited by 18 · see citing works

[Effects of extracts of cheezheng pain relieving plaster on nitric oxide and iNOS expression in macrophages induced by lipopolysaccharides].

Liu, Y., Peng, S.-Y., Wang, L., et al. (2009) · PubMed · Cited by 2 · see citing works

Effects of Kaempferol and Myricetin on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Rats

Rostoka, E., Baumane, L., Isajevs, S., et al. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00526.x · Cited by 28 · see citing works

Relationship of inducible nitric oxide synthase, nitric oxide with tumors

Gao, Z., Gao, W., & Huangfu, H. (2019) · doi:10.3760/cma.j.issn.1006-9801.2019.10.017

THE STUDY ON THE ROLE OF THE SUBSTRATE,INHIBITOR OF NOS AND PROVIDER OF NO IN RABBITS' INFECTION BY EIMERIA STIEDAI

Zhang, X. (2008) · Shandong Nongye Daxue xuebao