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Sleep duration and risk of stroke events and stroke mortality: A systematic review and meta-analysis of prospective cohort studies
Abstract
Background Numerous studies have suggested the relationship between sleep duration and risks of stroke mortality and morbidity, however, the effect estimates varied substantially across studies and it remains unknown how many hours of habitual sleep are associated with the lowest risk of stroke outcomes. Therefore, we performed a dose-response meta-analysis of prospective cohort studies to evaluate the relation of sleep duration with risk of total mortality and stroke events.Methods PubMed and Embase databases were searched through January 2016, and multivariate-adjusted relative risks were pooled by using fixed-effects models. Semiparametric and dose-response methods were used to assess the relationship of sleep duration and risk of stroke and stroke mortality.Results Eleven articles with 16 independent reports were included in our meta-analysis. An approximate J-shaped relationship was detected between sleep duration and risk of stroke and stroke mortality. No evidence of a curve linear relationship was seen between sleep duration and risk of stroke or stroke mortality. Compared with 7-h sleep duration per day, the pooled relative risks for stroke events were 1.07 (95% CI 1.02-1.12) for each 1-h shorter sleep duration among individuals who slept <7h per day and 1.17 (1.14-1.20) for each 1-h increase of sleep duration among individuals with longer sleep duration and the pooled RR for stroke mortality was 1.17 (95% CI 1.13-1.20) per 1-h increase of sleep duration.Conclusions Both short and long duration of sleep are predictors of stroke outcomes, and long sleep duration is significant marker of stroke mortality.
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“Suggestive evidence has shown that long sleep duration is positively linked with the morbidity of stroke (32) and mortality of stroke per 1-h increase in sleep duration (42).”
From Sleep Duration/Quality with Health Outcomes: An Umbrella Review of Meta-Analyses of Prospective Studies (2022) · cites this paper as [42]
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Metadata
- Authors
- Li, W., Wang, D., Cao, S., Yin, X., Gong, Y., Gan, Y., Zhou, Y., & Lu, Z.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- Corresponding author
- Lu, Zuxun
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 223
- Pages
- 870-876
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2509262111
- Cited by
- 130
- References
- 44
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 18 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 5 · 2016: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep duration, stroke, stroke mortality, J-shaped relationship, dose-response relationship, short sleep duration, long sleep, stroke risk factors
- MeSH terms
- Sleep Hygiene, Humans, Risk Factors, Sleep, Time Factors, Risk Assessment, Stroke
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