Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats
Abstract
Several studies have investigated the effects of artificial litter size adjustment on offspring development. Social play behavior is important for neurobehavioral development and is impaired in several developmental psychiatric disorders. This study therefore investigated the effect of litter size on play behavior in adolescent rats. On postnatal day (PND) 2, litters were adjusted to a small litter (SL) size of 3 pups per dam or normal litter (NL) size of 12 pups per dam. Maternal behaviors scored daily during the first week of lactation (PND2-8) revealed that arched nursing and pup licking behaviors were increased in dams with SLs versus those with NLs. SL offspring exhibited accelerated weight gain and advanced development of physical landmarks and reflexes, possibly due to overnutrition. Social isolation lasting 3.5h prior to social play behavioral testing produced a higher frequency and duration of pouncing, pinning, sniffing, and grooming in both male and female offspring. However, male SL offspring exhibited a lower frequency of pouncing and pinning when compared with male NL offspring, while no litter size-dependent differences were observed in social behaviors unrelated to play (sniffing and grooming). These findings identify a possible sexually dimorphic influence of litter size in the development of social behavior. Given that social behaviors such as play behavior are vital for normal cognitive and social development, these findings have important implications for…
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Early postnatal overnutrition was associated with decreases in social play behavior in adolescent male rats.
“Conversely, early postnatal overnutrition was associated with decreases in social play behavior in adolescent male rats61.”
Cites
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Prenatal stress feminizes juvenile play patterns in male rats
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Maternal Touch Moderates Sex Differences in Juvenile Social Play Behavior
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“Conversely, increased somatosensory contact from other offspring during the early neonatal period reduced male social play behavior and increased levels of 5HT2a mRNA in the juvenile amygdala (Edelmann et al., 2013), suggesting an inverse relationship between serotonin signaling and the frequency of social play in mal…”
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Reichelt, A. C., Loughman, A., Bernard, A., Raipuria, M., Abbott, K. N., Dachtler, J., Van, T. T. H., & Moore, R. J. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1537169 · Cited by 49 · see citing works
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- Authors
- Carvalho, A. L. O., Ferri, B. G., de Sousa, F. A. L., Vilela, F. C., & Giusti‐Paiva, A.
- Affiliations
- Universidade Federal de Alfenas (BR)
- Laboratório de Fisiologia Translacional, Departamento de Ciências Fisiológicas Instituto de Ciências Biomédicas Universidade Federal de Alfenas‐MG Alfenas Brazil
- Corresponding author
- Giusti‐Paiva, Alexandre
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2016-07-25
- Volume
- 53
- Issue
- 1
- Pages
- 75-82
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W2478703380
- Cited by
- 29
- References
- 5
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2018: 4 · 2017: 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (#456078/2014‐2, #300977/2013‐1)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (#01483/2013, #00041/2015AG‐P)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- litter size, overnutrition, social play, adolescent rats, maternal behavior, pup licking, sexual dimorphism, social behavior development, developmental programming, social isolation
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Body Weight, Female, Litter Size, Male, Maternal Behavior, Play and Playthings, Social Behavior, Rats, Wistar, Overnutrition, Rats
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