The DOI matches its Crossref record.
Malaria parasitemia and systemic cytokine bias in pregnancy
Abstract
OBJECTIVES: To investigate the effects of age, gravidity, and gestational age on peripheral malaria parasitemia and functional T helper (Th) cell heterogeneity in pregnant women. METHODS: Maternal age, gravidity, and gestational age were recorded and peripheral venous blood collected from 175 women attending antenatal clinics in south western Cameroon between March and September 2002. The blood was checked for malaria parasitemia by light microscopy and plasma levels of interleukin (IL)-4 and human interferon (IFN)-gamma were measured by indirect enzyme-linked immunosorbent assay. RESULTS: Malaria parasites were detected in 45 (25.4%) of 174 women, with rates similar for different age groups, trimesters of pregnancy, and gravidity. The geometric mean parasite density was 565, and parasite density was significantly higher in younger than in older women. For all groups combined, the mean IL-4 level was significantly higher than the mean IFN-gamma (P=0.0004), irrespective of the presence and density of malaria parasites, gravidity except for women in their first trimester of pregnancy and grandmultiparas, who had similar levels of IFN-gamma and IL-4. In general, the cytokine profile was biased toward Th2-type of responses in 112 (84.3%) of 132 women. CONCLUSIONS: In this study the ability to control malaria parasitemia during pregnancy was found to be predominantly age dependent, suggesting naturally acquired immunity. Furthermore, the systemic cytokine profile was found to be biased towards Th2 responses, a prerequisite for a successful pregnancy. This pattern was unaffected by maternal age, gestational age, gravidity, or parasitemia.
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“Besides the antibody responses to VSAPAM, cytokine responses such as Th1, Th2, interleukins, TNF and regulators, IFN gamma,70–72 and monocytes73 have been observed in pregnant women with malaria.”
From Malaria in pregnancy. (2013) · cites this paper as [71]
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Takem, E. N., & D'Alessandro, U. (2013) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2013.010 · Cited by 185
Metadata
- Authors
- Achidi, E. A., Apinjoh, T. O., & Titanji, V. P. K.
- Affiliations
- University of Buea (CM)
- Corresponding author
- Achidi, E.A.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2007-02-28
- Volume
- 97
- Issue
- 1
- Pages
- 15-20
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W1970347790
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 7
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Bank Group
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- malaria in pregnancy, parasitemia, parasite density, IL-4, interferon-gamma, maternal age, gravidity, gestational age, natural immunity
- MeSH terms
- Adult, Enzyme-Linked Immunosorbent Assay, Female, Gestational Age, Gravitation, T-Lymphocytes, Helper-Inducer, Humans, Interferon-gamma, Maternal Age, Parasite Egg Count, Pregnancy, Pregnancy Complications, Infectious, Interleukin-4, Malaria, Falciparum, Parasitemia
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