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Cited by 266Malaria Research and ControlHemoglobinopathies and Related DisordersPregnancy and preeclampsia studies

Plasmodium falciparum Isolates from Infected Pregnant Women and Children Are Associated with Distinct Adhesive and Antigenic Properties

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Beeson, James G., Brown, Graham V., Molyneux, Malcolm E., Mhango, Chisale, Dzinjalamala, Fraction, Rogerson, Stephen J.·1999·The Journal of Infectious Diseases
DOI 10.1086/314899PMC PMC2613477
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Abstract

Plasmodium falciparum malaria during pregnancy is an important cause of maternal and infant morbidity and mortality. Accumulation of large numbers of P. falciparum-infected erythrocytes in the maternal blood spaces of the placenta may be mediated by adhesion of infected erythrocytes to molecules presented on the syncytiotrophoblast surface. In this study, isolates from placentas and peripheral blood of infected pregnant women and from children were tested for binding to purified receptors and for agglutination with adult sera. Results suggest that adhesion to chondroitin sulfate A may be involved in placental parasite sequestration in most cases, but other factors are also likely to be important. Agglutination assay results suggest that parasites infecting pregnant women are antigenically distinct from those common in childhood disease. The prevalence of agglutinating antibodies to pregnancy isolates was generally low, but it was highest in multigravidae who are likely to have had the greatest exposure.

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  • P. falciparum placental parasites express unique variant surface antigens (VSA_PAM) that allow the parasite to sequester in the placenta by binding to chondroitin sulfate A (CSA) receptors on syncytiotrophoblast.

    “the parasite to sequester in the placenta by binding to chondroitin sulfate A (CSA) receptors on syncytiotrophoblast (Beeson et al. , 1999; Fried & Duffy, 1996; Ricke et al. , 2000; Tuikue Ndam et al. , 2004).”

    From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Beeson et al., 1999

    The Discussion (page unavailable) reports that most placental isolates bound CSA in vitro and generally supports a role for CSA on syncytiotrophoblasts in placental sequestration. It also reports antigenic differences between pregnancy and childhood isolates. But the paper does not establish CSA binding as the definitive mechanism for all placental parasites: some isolates did not bind the tested receptors, and the authors say other factors may contribute. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • CSA has been consistently identified as the dominant placental adhesion receptor.

    “C SA has been consistently identified as the dominant placental adhesion receptor (Beeson et al. , 1999; Fried & Duffy, 1996).”

    From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Beeson et al., 1999

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Research works printed but not linked: 42

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Authors
Beeson, J. G., Brown, G. V., Molyneux, M. E., Mhango, C., Dzinjalamala, F., & Rogerson, S. J.
Affiliations
  • The Royal Melbourne Hospital (AU)
  • Walter and Eliza Hall Institute of Medical Research (AU)
  • University of Liverpool (GB)
  • University of Malawi (MW)
Corresponding author
Beeson, James G.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1999-08
Volume
180
Issue
2
Pages
464-472
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/314899
PMC
PMC2613477
OpenAlex
W2160351496
Cited by
266
References
3
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 13 · 2013: 8 · 2012: 9
FWCI
17.06
Type
journal article
Language
en
Open access
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Wellcome Trust (063215)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
Plasmodium falciparum, malaria in pregnancy, placental malaria, parasite adhesion, chondroitin sulfate A, syncytiotrophoblast, parasite sequestration, agglutination, maternal antibodies, multigravida
MeSH terms
Adult, Animals, Cell Adhesion, Child, Chondroitin Sulfates, Erythrocytes, Female, Humans, Leukocytes, Mononuclear, Male, Placenta, Plasmodium falciparum, Pregnancy, Receptors, Cell Surface, Trophoblasts, Pregnancy Complications, Parasitic, Malaria, Falciparum, Parasitemia, Intercellular Adhesion Molecule-1, CD36 Antigens

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