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Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence

Suzuki, Yasunosuke, Yuen, Steven R., Ashley, Richard·2005·International Journal of Hygiene and Environmental Health
DOI 10.1016/j.ijheh.2005.01.015
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Abstract

Based on animal studies, long and thin asbestos fibers (> or =8 microm in length and < or = 0.25 microm in width) have been postulated to be strongly carcinogenic inducing pleural malignant mesothelioma, while shorter, thicker fibers have been postulated to pose a lesser risk (Stanton hypothesis). The objective of this study is to test the validity of the Stanton hypothesis through direct pathologic analysis of human mesothelioma tissue. Digested bulk tissue samples, or ashed 25 microm thick sections, or both, were prepared from lung and mesothelial tissues taken from 168 cases of human malignant mesothelioma. In these tissues, 10,575 asbestos fibers (4820 in the lung and 5755 in mesothelial tissues (1259 in fibrotic serosa and 4496 in mesotheliomatous tissue)) were identified by high-resolution analytical electron microscopy. Dimensions of these asbestos fibers were measured in printed electron micrographs. Results were as follows: (1) long, thin asbestos fibers consistent with the Stanton hypothesis comprised only 2.3% of total fibers (247 / 10,575) in these tissues; (2) the majority (89.4%) of the fibers in the tissues examined were shorter than or equal to 5 microm in length (9454 of 10,575), and generally (92.7%) smaller than or equal to 0.25 microm in width (9808 of 10,575). (3) Among asbestos types detected in the lung and mesothelial tissues, chrysotile was the most common asbestos type to be categorized as short, thin asbestos fibers. (4) Compared with digestion tech…

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Metadata

Authors
Suzuki, Y., Yuen, S. R., & Ashley, R.
Venue
International Journal of Hygiene and Environmental Health
Publisher
Elsevier BV
Published
2005-05
Volume
208
Issue
3
Pages
201-210
ISSN
1438-4639
DOI
10.1016/j.ijheh.2005.01.015
Cited by
136
References
0
Language
en
Update notices
erratum (2005-09-16)
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CoChat. (2026). Citation check: Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. https://app.cochat.ai/papers/10.1016/j.ijheh.2005.01.015
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Suzuki, Y., Yuen, S. R., & Ashley, R. (2005). Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. International Journal of Hygiene and Environmental Health. https://doi.org/10.1016/j.ijheh.2005.01.015