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Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic
Open accessAbstract
Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society.
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“Respired biopersistent fibres such as asbestos were found to cause severe pulmonary diseases and led to proposing the fibre-pathogenicity paradigm [1–3].”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [3]
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References 190 · Cited by 185
Research works printed but not linked: 4
- European Union, 1999, Commission Directive 1999/77/EC of 26 July 1999, Off J Eur Comm, L207, 18
- 10.1093/annhyg/45.7.513 · DOI
- 10.1111/j.1349-7006.2012.02223.x · DOI
- Thiele C , Das R. Carbon Nanotubes and Graphene for Electronics Applications: Technologies, Players & Opportunities. Cambridge, IDTechEX, 2009.
Metadata
- Authors
- Røe, O. D., & Stella, G. M.
- Affiliations
- Norwegian University of Science and Technology (NO)
- University of Pavia (IT)
- Corresponding author
- Røe, Oluf Dimitri
- Venue
- European Respiratory Review
- Publisher
- European Respiratory Society (ERS)
- Published
- 2015-02-28
- Volume
- 24
- Issue
- 135
- Pages
- 115-131
- ISSN
- 0905-9180 (ISSN-L)
- 1600-0617
- PMC
- PMC9487774
- OpenAlex
- W2121348722
- Cited by
- 185
- References
- 190
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 16 · 2023: 15 · 2022: 23 · 2021: 24 · 2020: 18 · 2019: 18 · 2018: 20 · 2017: 12 · 2016: 12 · 2015: 11
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- European Respiratory Review (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Funders
- Nanjing Medical University
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Social Sciences › Health › Occupational Health and Global Justice
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- malignant pleural mesothelioma, asbestos, etiology, circulating biomarkers, microRNA, carbon nanofibers, occupational exposure, cancer diagnosis, treatment goals
- MeSH terms
- Mesothelioma, Malignant, Animals, Asbestos, Asbestosis, Humans, Lung Neoplasms, Mesothelioma, Occupational Diseases, Pleural Neoplasms, Simian virus 40, Viral Vaccines, Biomarkers, Occupational Exposure, Poliovirus Vaccines, History, 18th Century, History, 20th Century
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