The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Self-associating autotransporters, SAATs: Functional and structural similarities
Abstract
The autotransporter family of translocated proteins in Gram-negative bacteria all contain three structural motifs, a signal sequence, a passenger domain and a translocator domain. The autotransporters constitute a highly versatile group of proteins with respect to function, which accords with the widespread presence of these proteins. The group encompasses many important virulence factors. In Escherichia coli, a subgroup of autotransporter proteins consists of the TibA adhesin/invasin associated with some enterotoxigenic E. coli, the AIDA adhesin from diarrhea-causing E. coli and finally, the Ag43 autoaggregation factor found in the majority of E. coli strains. The three proteins exhibit approximately 25% identity at the sequence level, and are quite different with respect to size, glycosylation and processing. Nevertheless, they share some important properties: all are self-associating proteins that cause bacterial aggregation. They can also interact with each other via heterologous interactions to cause formation of mixed bacterial aggregates. Furthermore, these proteins enhance biofilm formation. Based on these properties we propose to classify them together in a group termed SAATs: self-associating autotransporters.
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“Among these, particularly the self-associating autotransporters (SAATs) of the Enterobacteriaceae (representing type Va) [69] and many type Vc secreted-proteins, such as the Yersinia adhesin YadA, BadA from Bartonella henselae and AtaA from certain strains of Acinetobacter baumannii [20],[23],[70], promote strong autoaggregation.”
From Bacterial autoaggregation (2018) · cites this paper as [69]
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Cites
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Type V Protein Secretion Pathway: the Autotransporter Story
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Global gene expression in Escherichia coli biofilms
Schembri, M. A., Kjærgaard, K., & Klemm, P. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03432.x · Cited by 556
Quorum Sensing-Dependent Biofilms Enhance Colonization in Vibrio cholerae
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Bacterial adhesins: function and structure
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Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. I. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,099
Beloin, C., Roux, A., & Ghigo, J. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75418-3_12 · Cited by 582
Trunk, T., Bacterial Cell Surface Group, S. F. G. A. E. B., S. Khalil, H., & C. Leo, J. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.1.140 · Cited by 444
“Among these, particularly the self-associating autotransporters (SAATs) of the Enterobacteriaceae (representing type Va) [69] and”
BackgroundAdhesins Involved in Attachment to Abiotic Surfaces by Gram-Negative Bacteria
Berne, C., Ducret, A., Hardy, G. G., & Brun, Y. V. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mb-0018-2015 · Cited by 366
Intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens
Giaouris, E. D., Heir, E., Desvaux, M., Hébraud, M., Møretrø, T., Langsrud, S., Doulgeraki, A. I., Nychas, G. E., Kačániová, M., Czaczyk, K., et al. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00841 · Cited by 348
Metadata
- Authors
- Klemm, P., Vejborg, R. M., & Sherlock, O.
- Affiliations
- Technical University of Denmark (DK)
- Corresponding author
- Klemm, Per
- Venue
- International Journal of Medical Microbiology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 296
- Issue
- 4-5
- Pages
- 187-195
- ISSN
- 1438-4221 (ISSN-L)
- OpenAlex
- W1982077771
- Cited by
- 109
- References
- 43
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Funders
- Teknologi og Produktion, Det Frie Forskningsråd
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- autotransporters, Escherichia coli, bacterial adhesins, virulence factors, bacterial aggregation, biofilm formation, enterotoxigenic Escherichia coli, signal peptide, passenger domain, protein glycosylation, protein processing
- MeSH terms
- Bacterial Adhesion, Bacterial Outer Membrane Proteins, Biological Transport, Carrier Proteins, Escherichia coli, Gram-Negative Bacteria, Hydrogen-Ion Concentration, Fimbriae, Bacterial, Bacterial Capsules, Biofilms, Adhesins, Bacterial, Adhesins, Escherichia coli
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