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Cited by 110Parasites and Host InteractionsInflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways

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Translatability of helminth therapy in inflammatory bowel diseases

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Weinstock, Joel V., Elliott, David E.·2013·International Journal for Parasitology
DOI 10.1016/j.ijpara.2012.10.016PMC PMC3683647
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Abstract

Modern hygienic lifestyles are associated with the emergence of inflammatory bowel disease (IBD) which now afflicts millions of people in highly-developed countries. Meticulous hygiene interrupts conduits of transmission required for ubiquitous exposure to parasitic worms (helminths). We proposed that loss of exposure to helminths permits development of IBD. Early clinical trials suggested that exposure to helminths such as Trichuris suis or Necator americanus can improve IBD. Over the last several years, processes to "medicinalize"T. suis have been developed and use of this helminth is now being studied in large multi-center clinical trials. Concurrently, we and others have identified some of the immune regulatory mechanisms elicited by helminth exposure that suppress inappropriate intestinal inflammation. These efforts could soon result in new therapies for patients with IBD.

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Metadata

Authors
Weinstock, J. V., & Elliott, D. E.
Affiliations
  • Tufts Medical Center (US)
  • University of Iowa (US)
Corresponding author
  • Weinstock, Joel V.
  • Elliott, David E.
ORCID
Venue
International Journal for Parasitology
Publisher
Elsevier BV
Published
2013-03
Volume
43
Issue
3-4
Pages
245-251
ISSN
0020-7519 (ISSN-L)
DOI
10.1016/j.ijpara.2012.10.016
PMC
PMC3683647
OpenAlex
W1980609624
Cited by
110
References
2
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 12 · 2018: 12 · 2017: 4 · 2016: 14 · 2015: 13 · 2014: 27 · 2013: 4
FWCI
1.72
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal for Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK058755, R56DK058755, R01DK058755, DK091987, R01DK091987)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
inflammatory bowel disease, helminth therapy, Trichuris suis, Necator americanus, immune regulation, intestinal inflammation, hygiene hypothesis, translational medicine, clinical trials
MeSH terms
Animals, Helminths, Humans, Inflammatory Bowel Diseases, Therapy with Helminths

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