Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,478 · see citing works

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,255 · see citing works

A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 1,946 · see citing works

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,827 · see citing works

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127 · see citing works

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions

Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G., & Förster, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.014 · Cited by 1,086 · see citing works

Mechanisms of suppression by suppressor T cells

von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1180 · Cited by 1,005 · see citing works

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

Fontenot, J. D., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1179 · Cited by 947 · see citing works

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

Gondek, D. C., Lu, L., Quezada, S. A., Sakaguchi, S., & Noelle, R. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.1783 · Cited by 943 · see citing works

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

Powrie, F. M., Carlino, J. A., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2669 · Cited by 894 · see citing works

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

Wan, Y. Y., & Flavell, R. A. (2007) · Nature · doi:10.1038/nature05479 · Cited by 855 · see citing works

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

Williams, L. M., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1437 · Cited by 854 · see citing works

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835 · see citing works

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals <i>in vivo</i>

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806 · see citing works

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

Li, M. O., Wan, Y. Y., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.014 · Cited by 728 · see citing works

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724 · see citing works

Natural regulatory T cells: mechanisms of suppression

Miyara, M., & Sakaguchi, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.01.003 · Cited by 714 · see citing works

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

Bopp, T., Becker, C., Klein, M., Klein‐Hessling, S., Palmetshofer, A., Serfling, E., Heib, V., Becker, M., Kubach, J., Schmitt, S., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062129 · Cited by 659 · see citing works

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

Gavin, M. A., Clarke, S. R. M., Negrou, E., Gallegos, A. M., & Rudensky, A. Y. (2001) · Nature Immunology · doi:10.1038/ni743 · Cited by 640 · see citing works

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599 · see citing works

Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

Jankovic, D. L., Kullberg, M. C., Feng, C. G., Goldszmid, R. S., Collazo, C. M., Wilson, M. D., Wynn, T. A., Kamanaka, M., Flavell, R. A., & Sher, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062175 · Cited by 590 · see citing works

CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Anderson, C. F., Oukka, M., Kuchroo, V. K., & Sacks, D. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061886 · Cited by 571 · see citing works

Control of T‐cell activation by CD4+ CD25+ suppressor T cells

Shevach, E. M., McHugh, R. S., Piccirillo, C. A., & Thornton, A. M. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820104.x · Cited by 544 · see citing works

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516 · see citing works

Control of intestinal inflammation by regulatory T cells

Singh, B., Read, S., Asseman, C., Malmström, V., Mottet, C., Stephens, L. A., Štëpánková, R., Tlaskalová, H., & Powrie, F. M. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820115.x · Cited by 500 · see citing works

Mast cell–derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B

Grimbaldeston, M. A., Nakae, S., Kalesnikoff, J., Tsai, M. M., & Galli, S. J. (2007) · Nature Immunology · doi:10.1038/ni1503 · Cited by 486 · see citing works

Regulatory T cell development in the absence of functional Foxp3

Lin, W. X., Haribhai, D., Relland, L. M., Truong, N., Carlson, M. R. J., Williams, C. B., & Chatila, T. A. (2007) · Nature Immunology · doi:10.1038/ni1445 · Cited by 485 · see citing works

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

Uhlig, H. H., Coombes, J. L., Mottet, C., Ízcue, A., Thompson, C., Fanger, A., Tannapfel, A., Fontenot, J. D., Ramsdell, F., & Powrie, F. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5852 · Cited by 463 · see citing works

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.013 · Cited by 392 · see citing works

Distinct roles of CTLA‐4 and TGF‐β in CD4+CD25+ regulatory T cell function

Tang, Q., Boden, E. K., Henriksen, K., Bour‐Jordan, H., Bi, M., & Bluestone, J. A. (2004) · European Journal of Immunology · doi:10.1002/eji.200425143 · Cited by 377 · see citing works

Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4 + CD25 + regulatory T‐cell‐mediated suppression

Oderup, C., Cederbom, L., Makowska, A. M., Cilio, C., & Ivars, F. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02362.x · Cited by 338 · see citing works

Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis

Nylén, S., Maurya, R., Eidsmo, L., Manandhar, K. D., Sundar, S., & Sacks, D. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061141 · Cited by 329 · see citing works

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

Paust, S., Lu, L., McCarty, N., & Cantor, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403342101 · Cited by 328 · see citing works

The importance of leukotrienes in airway inflammation in a mouse model of asthma.

Henderson, W. R., Lewis, D. B., Albert, R. K., Zhang, Y., Lamm, W. J., Chiang, G. K. S., Jones, F., Eriksen, P., Tien, Y.-T., Jonas, M., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1483 · Cited by 313 · see citing works

T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation

Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schlüter, D., Stenzel, W., Gruber, A. D., Krieg, T. M., Rajewsky, K., & Müller, W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041789 · Cited by 309 · see citing works

FOXP3+CD4+CD25+ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E2-Dependent Mechanism

Mahic, M., Yaqub, S., Johansson, C. C., Taskén, K., & Aandahl, E. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.246 · Cited by 245 · see citing works

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

Berg, D., Leach, M. W., Kühn, R., Rajewsky, K., Müller, W., Davidson, N. J., & Rennick, D. M. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.1.99 · Cited by 238 · see citing works

IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

Mäkelä, M. J., Kanehiro, A., Borish, L., Dakhama, A., Loader, J., Joetham, A., Xing, Z., Jordana, M., Larsen, G. L., & Gelfand, E. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100118997 · Cited by 198 · see citing works

Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model

Henderson, W. R., Chi, E. Y., Bollinger, J. G., Tien, Y.-T., Ye, X., Castelli, L., Rubtsov, Y. P., Singer, A. G., Chiang, G. K. S., Nevalainen, T. J., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070029 · Cited by 189 · see citing works

Influence of the Route of Allergen Administration and Genetic Background on the Murine Allergic Pulmonary Response

Zhang, Y., Lamm, W. J., Albert, R. K., Chi, E. Y., Henderson, W. R., & Lewis, D. B. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032210 · Cited by 184 · see citing works

Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice

Burich, A., Hershberg, R. M., Waggie, K. S., Zeng, W., Brabb, T., Westrich, G., Viney, J. L., & Maggio‐Price, L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g764 · Cited by 179 · see citing works

Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10

Asseman, C., Read, S., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.971 · Cited by 172 · see citing works

IPEX and FOXP3: Clinical and research perspectives

Wildin, R. S., & Freitas, A. A. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.04.008 · Cited by 166 · see citing works

TGF‐β1 production by CD4+CD25+ regulatory T cells is not essential for suppression of intestinal inflammation

Kullberg, M. C., Hay, V., Cheever, A. W., Mamura, M., Sher, A., Letterio, J. J., Shevach, E. M., & Piccirillo, C. A. (2005) · European Journal of Immunology · doi:10.1002/eji.200526106 · Cited by 118 · see citing works

Full restoration of peripheral Foxp3 + regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

Komatsu, N., & Hori, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702004104 · Cited by 98 · see citing works

Interleukin-10 in the regulation of T cell-induced colitis

Annacker, O., Asseman, C., Read, S., & Powrie, F. M. (2003) · Journal of Autoimmunity · doi:10.1016/s0896-8411(03)00045-3 · Cited by 89 · see citing works

Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model

Henderson, W. R., Banerjee, E. R., & Chi, E. Y. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.04.013 · Cited by 61 · see citing works

Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis

Drakes, M. L., Blanchard, T. G., & Czinn, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605342 · Cited by 32 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

How regulatory T cells work

Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works

Roles of the immune system in cancer: From tumor initiation to metastatic progression

Gonzalez, H., Hagerling, C., & Werb, Z. (2018) · Genes &amp; Development · doi:10.1101/gad.314617.118 · Cited by 2,111 · see citing works

The PD‐1 pathway in tolerance and autoimmunity

Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300 · see citing works

The microbiota in adaptive immune homeostasis and disease

Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · see citing works

CD4 T cells: fates, functions, and faults

Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,796 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,769 · see citing works

Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292 · see citing works

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

Watson, M. J., Vignali, P., Mullett, S. J., Overacre-Delgoffe, A. E., Peralta, R. M., Grebinoski, S., Menk, A. V., Rittenhouse, N., DePeaux, K., Whetstone, R. D., et al. (2021) · Nature · doi:10.1038/s41586-020-03045-2 · Cited by 1,280 · see citing works

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258 · see citing works

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Angelin, A., Gil‐de‐Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.018 · Cited by 1,263 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

Regulatory T Cells and Human Disease

Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,132 · see citing works

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M., Strom, T. B., Elyaman, W., Ho, I.-C., et al. (2008) · Nature Immunology · doi:10.1038/ni.1677 · Cited by 1,122 · see citing works

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,115 · see citing works

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Wing, K., & Sakaguchi, S. (2009) · Nature Immunology · doi:10.1038/ni.1818 · Cited by 1,110 · see citing works

A Distinct Function of Regulatory T Cells in Tissue Protection

Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991 · see citing works

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980 · see citing works

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

Lu, L., Boldin, M., Chaudhry, A., Lin, L.-L., Taganov, K. D., Hanada, T., Yoshimura, A., Baltimore, D., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.08.012 · Cited by 1,003 · see citing works

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

Chaudhry, A., Rudra, D., Treuting, P., Samstein, R. M., Liang, Y., Kas, A., & Rudensky, A. Y. (2009) · Science · doi:10.1126/science.1172702 · Cited by 1,000 · see citing works

Macrophages: Development and Tissue Specialization

Varol, C., Mildner, A., & Jung, S. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112220 · Cited by 962 · see citing works

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958 · see citing works

Th17 and regulatory T cells in mediating and restraining inflammation

Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039 · see citing works

Biology of interleukin-10

Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977 · see citing works

An essential role for the IL-2 receptor in Treg cell function

Chinen, T., Kannan, A., Levine, A. G., Fan, X., Klein, U., Zheng, Y., Gasteiger, G., Feng, Y., Fontenot, J. D., & Rudensky, A. Y. (2016) · Nature Immunology · doi:10.1038/ni.3540 · Cited by 885 · see citing works

Individual intestinal symbionts induce a distinct population of RORγ ⁺ regulatory T cells

Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works

Regulatory T cells: how do they suppress immune responses?

Sakaguchi, S., Wing, K., Onishi, Y., Martín, P. P., & Yamaguchi, T. (2009) · International Immunology · doi:10.1093/intimm/dxp095 · Cited by 850 · see citing works

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851 · see citing works

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Walker, L. S. K., & Sansom, D. M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3108 · Cited by 786 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Zeng, H., Yang, K., Cloer, C., Neale, G. A. M., Vogel, P., & Chi, H. (2013) · Nature · doi:10.1038/nature12297 · Cited by 789 · see citing works

Molecular Mechanisms of Treg-Mediated T Cell Suppression

Schmidt, A., Oberle, N., & Krammer, P. H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00051 · Cited by 760 · see citing works

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 750 · see citing works

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

Shen, Y., Torchia, M. L. G., Lawson, G. W., Karp, C. L., Ashwell, J. D., & Mazmanian, S. K. (2012) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2012.08.004 · Cited by 714 · see citing works

Experimental Models of Inflammatory Bowel Diseases

Kiesler, P., Fuss, I. J., & Strober, W. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.006 · Cited by 719 · see citing works

Phenotypical and functional specialization of FOXP3+ regulatory T cells

Campbell, D. J., & Koch, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2916 · Cited by 773 · see citing works

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680 · see citing works

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Overacre-Delgoffe, A. E., Chikina, M., Dadey, R. E., Yano, H., Brunazzi, E. A., Shayan, G., Horne, W., Moskovitz, J. M., Kolls, J. K., Sander, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.005 · Cited by 627 · see citing works

Macrophages in intestinal homeostasis and inflammation

Bain, C. C., & Mowat, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12192 · Cited by 615 · see citing works

tTregs, pTregs, and iTregs: similarities and differences

Shevach, E. M., & Thornton, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12160 · Cited by 607 · see citing works

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605 · see citing works

Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

Tay, C., Tanaka, A., & Sakaguchi, S. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.014 · Cited by 594 · see citing works

A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes

Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586 · see citing works

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

Hill, D. A., & Artis, D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101330 · Cited by 586 · see citing works

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

Huber, S., Gagliani, N., Esplugues, E., O'Connor, W., Huber, F. J., Chaudhry, A., Kamanaka, M., Kobayashi, Y., Booth, C. J., Rudensky, A. Y., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.020 · Cited by 581 · see citing works

Immunological pathogenesis of inflammatory bowel disease

Lee, S., Kwon, J. E., & Cho, M. (2018) · Intestinal Research · doi:10.5217/ir.2018.16.1.26 · Cited by 581 · see citing works

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sivaprakasam, S., Prasad, P. D., & Singh, N. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.007 · Cited by 573 · see citing works

Heterogeneity and plasticity of T helper cells

Zhu, J., & Paul, W. E. (2009) · Cell Research · doi:10.1038/cr.2009.138 · Cited by 564 · see citing works

Development and maintenance of intestinal regulatory T cells

Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553 · see citing works

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560 · see citing works

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C., Yona, S., Kim, K.-W., Brenner, O. J., Krauthgamer, R., Varol, C., Müller, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.012 · Cited by 554 · see citing works

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Carlini, V., Noonan, D. M., Abdalalem, E., Goletti, D., Sansone, C., Calabrone, L., & Albini, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161067 · Cited by 570 · see citing works

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Sawant, D. V., Yano, H., Chikina, M. D., Zhang, Q., Liao, M., Liu, C., Callahan, D. J., Sun, Z., Sun, T., Tabib, T., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0346-9 · Cited by 547 · see citing works

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Xu, C., Sun, S., Johnson, T. S., Qi, R. A., Zhang, S., Zhang, J., & Yang, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109235 · Cited by 528 · see citing works

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

Zhou, X., Jeker, L. T., Fife, B. T., Zhu, S., Anderson, M. S., McManus, M. T., & Bluestone, J. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080707 · Cited by 528 · see citing works

Continuous requirement for the TCR in regulatory T cell function

Levine, A. G., Arvey, A. J., Jin, W., & Rudensky, A. Y. (2014) · Nature Immunology · doi:10.1038/ni.3004 · Cited by 523 · see citing works

Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent, accumulation of regulatory T cells

Kuswanto, W., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y., Wagers, A., Benoist, C., & Mathis, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 483 · see citing works

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

D’Alessio, F. R., Tsushima, K., Aggarwal, N. R., West, E. E., Willett, M. H., Britos, M. F., Pipeling, M. R., Brower, R. G., Tuder, R. M., McDyer, J. F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36498 · Cited by 564 · see citing works

Regulatory Lymphocytes and Intestinal Inflammation

Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 505 · see citing works

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., et al. (2016) · Nature Immunology · doi:10.1038/ni.3365 · Cited by 470 · see citing works

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Li, M. O., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.003 · Cited by 501 · see citing works

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

Fagarasan, S., Kawamoto, S., Kanagawa, O., & Suzuki, K. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101314 · Cited by 500 · see citing works

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R. (2018) · Nature · doi:10.1038/nature25500 · Cited by 498 · see citing works

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 496 · see citing works

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472 · see citing works

Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus

Sun, L., Wang, D., Liang, J., Zhang, H., Feng, X., Wang, H., Hua, B., Liu, B., Ye, S., Hu, X., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27548 · Cited by 475 · see citing works

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, A., Cheng, F., Wang, H.-W., Suarez, I., Glozak, M., Maurin, M., Nguyen, D., Wright, K. L., Atadja, P. W., Bhalla, K., et al. (2009) · Nature Immunology · doi:10.1038/ni.1673 · Cited by 455 · see citing works

Principles of regulatory T cell function

Dikiy, S., & Rudensky, A. Y. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.004 · Cited by 450 · see citing works

The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis

Steen, E. H., Wang, X., Balaji, S., Butte, M. J., Bollyky, P. L., & Keswani, S. G. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.1032 · Cited by 442 · see citing works

Regulatory immune cells in transplantation

Wood, K. J., Bushell, A., & Hester, J. (2012) · Nature reviews. Immunology · doi:10.1038/nri3227 · Cited by 433 · see citing works

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Rudra, D., DeRoos, P. C., Chaudhry, A., Niec, R. E., Arvey, A. J., Samstein, R. M., Leslie, C. S., Shaffer, S. A., Goodlett, D. R., & Rudensky, A. Y. (2012) · Nature Immunology · doi:10.1038/ni.2402 · Cited by 431 · see citing works

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413 · see citing works

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Field, C. S., Baixauli, F., Kyle, R. L., Puleston, D. J., Cameron, A. M., Sanin, D. E., Hippen, K. L., Loschi, M. L., Thangavelu, G., Corrado, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.021 · Cited by 428 · see citing works

Lipid signalling enforces functional specialization of Treg cells in tumours

Lim, S. A., Wei, J., Nguyen, T.-L. M., Shi, H., SU, W. W., Palacios, G. F., Dhungana, Y., Chapman, N. M., Long, L., Saravia, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03235-6 · Cited by 434 · see citing works

Intestinal Commensal Microbes as Immune Modulators

Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 425 · see citing works

Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome

Fujimura, K. E., & Lynch, S. V. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.007 · Cited by 414 · see citing works

Novel Foxo1-dependent transcriptional programs control Treg cell function

Ouyang, W., Liao, W., Luo, C. T., Yin, N., Huse, M., Kim, M. V., Peng, M., Chan, P., Ma, Q., Mo, Y., et al. (2012) · Nature · doi:10.1038/nature11581 · Cited by 414 · see citing works

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

Huynh, A., DuPage, M. J. P., Priyadharshini, B., Sage, P. T., Quiros, J., Borges, C. M., Townamchai, N., Gerriets, V. A., Rathmell, J. C., Sharpe, A. H., et al. (2015) · Nature Immunology · doi:10.1038/ni.3077 · Cited by 412 · see citing works

IL-10: A Multifunctional Cytokine in Viral Infections

Rojas, J. M., Avia, M., Martı́n, V., & Sevilla, N. (2017) · Journal of Immunology Research · doi:10.1155/2017/6104054 · Cited by 414 · see citing works

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

Amit, I., Winter, D. R., & Jung, S. (2015) · Nature Immunology · doi:10.1038/ni.3325 · Cited by 406 · see citing works

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

Rubin, D. C., Shaker, A., & Levin, M. S. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00107 · Cited by 406 · see citing works

Diversity in the contribution of interleukin‐10 to T‐cell‐mediated immune regulation

Maynard, C. L., & Weaver, C. T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00711.x · Cited by 404 · see citing works

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 401 · see citing works

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Bailey-Bucktrout, S. L., Martínez‐Llordella, M., Zhou, X., Anthony, B. A., Rosenthal, W. L., Luche, H., Fehling, H. J., & Bluestone, J. A. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.016 · Cited by 399 · see citing works

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works

Stability and function of regulatory T cells expressing the transcription factor T-bet

Levine, A. G., Mendoza, A., Hemmers, S., Moltedo, B., Niec, R. E., Schizas, M., Hoyos, B. E., Putintseva, E. V., Chaudhry, A., Dikiy, S., et al. (2017) · Nature · doi:10.1038/nature22360 · Cited by 394 · see citing works

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

Abdel-Gadir, A., Victor, E. S., Gerber, G. K., Rivas, M. N., Wang, S., Harb, H., Wang, L., Li, N., Crestani, E., Spielman, S. C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0461-z · Cited by 392 · see citing works

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

Desreumaux, P., Foussat, A., Allez, M., Beaugerie, L., Hébuterne, X., Bouhnik, Y., Nachury, M., Brun, V., Bastian, H., Belmonte, N., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.116 · Cited by 386 · see citing works

Dicer-dependent microRNA pathway safeguards regulatory T cell function

Liston, A., Lu, L., O’Carroll, D., Tarakhovsky, A., & Rudensky, A. Y. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081062 · Cited by 378 · see citing works

Regulatory T Cells Reinforce Intestinal Homeostasis

Barnes, M. J., & Powrie, F. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.011 · Cited by 377 · see citing works

Regulatory T cells in allergic diseases

Rivas, M. N., & Chatila, T. A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.003 · Cited by 378 · see citing works

SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels

Lorenz, U. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00760.x · Cited by 370 · see citing works

Interleukin 10 acts on regulatory T cells to maintain Foxp3 expression and suppressive function in mice with colitis.

Murai, M., Kim, G., Madan, R., Karp, C., Cheroutre, H., & Kronenberg, M. (2011) · Inflammatory Bowel Diseases · doi:10.1093/ibd/17.supplement1.s24

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980 · see citing works

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851 · see citing works

Regulatory T cells: how do they suppress immune responses?

Sakaguchi, S., Wing, K., Onishi, Y., Martín, P. P., & Yamaguchi, T. (2009) · International Immunology · doi:10.1093/intimm/dxp095 · Cited by 850 · see citing works

Regulatory T cells in infection and autoimmunity

Rudensky, A. Y. (2009)